Increase of integration events and infection loads of human papillomavirus type 52 with lesion severity from low-grade cervical lesion to invasive cancer

Journal of Clinical Microbiology

Volumn 46, Issue 4, 2008, Pages 1356-1362

  Cheung, Jo L K ^a   Cheung, T H ^a   Tang, Julian W T ^a   Chan, Paul K S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN E2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; PROTEIN E7; VIRUS DNA;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; VIRUS DNA CELL DNA INTERACTION; VIRUS INFECTION; VIRUS LOAD; WART VIRUS; GENETICS; HONG KONG; HOSPITALIZATION; MIDDLE AGED; PAPILLOMA VIRUS; PATHOGENICITY; PATHOLOGY; UTERINE CERVIX; UTERINE CERVIX TUMOR; VIROLOGY;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 52; PAPILLOMAVIRIDAE;

ADULT; AGED; AGED, 80 AND OVER; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; DNA, VIRAL; FEMALE; HONG KONG; HUMANS; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS E7 PROTEINS; PAPILLOMAVIRUS INFECTIONS; SEVERITY OF ILLNESS INDEX; UTERINE CERVICAL NEOPLASMS; VIRAL LOAD; VIRUS INTEGRATION;

EID: 42449095009     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.01785-07     Document Type: Article

References (41)

1. Anderssen, S., H. Safari, M. Mints, I. Lewensohn-Fuchs, U. Gyllensten, and B. Johansson. 2005. Type distribution, viral load and integration status of high-risk human papillomaviruses in pre-stages of cervical cancer (CIN). Br. J. Cancer 92:2195-2200.
2. Arias-Pulido, H., C. L. Peyton, N. E. Joste, H. Vargas, and C. M. Wheeler. 2006. Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J. Clin. Microbiol. 44:1755-1756.
3. Badaracco, G., A. Venuti, A. Sedati, and M. L. Marcante. 2002. HPV16 and HPV18 in genital tumors: significantly different levels of viral integration and correlation to tumor invasiveness. J. Med. Virol. 67:574-582.
4. Bosch, F. X., A. Lorinzc, N. Munoz, C. J. Meijer, and K. V. Shah. 2002. The causal relation between human papillomavirus and cervical cancer. J. Clin. Pathol. 55:244-265.
5. Castle, P. E., M. Schiffman, D. R. Scott, M. E. Sherman, A. G. Glass, B. B. Rush, J. E. Schussler, S. Wacholder, and A. T. Lorincz. 2005. Semiquantitative human papillomavirus type 16 viral load and the prospective risk of cervical precancer and cancer. Cancer Epidemiol. Biomarkers Prev. 14: 1311-1314.
6. Chan, P. K., J. L. Cheung, T. H. Cheung, K. W. K. Lo, S. F. Yim, S. S. N. Siu, and J. W. Tang. 2007. Profile of viral load, integration and E2 disruption of HPV58 in normal cervix and cervical neoplasia. J. Infect. Dis. 196:868-875.
7. Chan, P. K., T. H. Cheung, A. O. Tam, K. W. Lo, S. F. Yim, M. M. Yu, K. F. To, Y. F. Wong, J. L. Cheung, D. P. Chan, M. Hui, and M. Ip. 2006. Biases in human papillomavirus genotype prevalence assessment associated with commonly used consensus primers. Int. J. Cancer 118:243-245.
8. Cheung, J. L., K. W. Lo, T. H. Cheung, J. W. Tang, and P. K. Chan. 2006. Viral load, E2 gene disruption status and lineage of human papillomavirus type 16 infection in cervical neoplasia. J. Infect. Dis. 194:1706-1712.
9. Dai, M., Y. P. Bao, G. M. Clifford, S. Vaccarella, P. J. Snijders, R. D. Huang, L. X. Sun, C. J. Meijer, Y. L. Qiao, and S. Franceschi. 2006. Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study. Br. J. Cancer 95:96-101.
10. Doorbar, J. 2006. Molecular biology of human papillomavirus infection and cervical cancer. Clin. Sci. 110:525-541.
11. el Awady, M. K., J. B. Kaplan, S. J. O'Brien, and R. D. Burk. 1987. Molecular analysis of integrated human papillomavirus 16 sequences in the cervical cancer cell line SiHa. Virology 159:389-398.
12. Häfner, N., C. Driesch, M. Gajda, L. Jansen, R. Kirchmayr, I. B. Runnebaum, and M. Dürst. 10 September 2007. Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts. Oncogene. doi:10.1038/sj.onc.1210791.
13. Ho, C. M., T. Y. Chien, S. H. Huang, B. H. Lee, and S. F. Chang. 2005. Integrated human papillomavirus types 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancer. Gynecol. Oncol. 102:54-60.
14. Hong Kong Cancer Registry, Hospital Authority. Fast stats on cervix cancer Stat 2004. Hong Kong Cancer Registry, Hospital Authority. http://www3.ha .org.hk/cancereg/eng/cx.pdf.
15. Huang, S., I. Afonina, B. A. Miller, and A. M. Beckmann. 1997. Human papillomavirus types 52 and 58 are prevalent in cervical cancers from Chinese women. Int. J. Cancer 70:408-411.
16. Jeon, S., B. L. Allen-Hoffmann, and P. F. Lambert. 1995. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J. Virol. 69:2989-2997.
17. Jeon, S., and P. F. Lambert. 1995. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc. Natl. Acad. Sci. USA 92:1654-1658.
18. Josefsson, A. M., P. K. Magnussen, N. Ylitalo, P. Sorensen, P. Qwarforth-Tubbin, P. K. Andersen, M. Melbye, H. Q. Adami, and U. B. Gyllensten. 2000. Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study. Lancet 355:2189-2193.
19. Kalantari, M., F. Karlsen, G. Kristensen, R. Holm, B. Hagmar, and B. Johansson. 1998. Disruption of the E1 and E2 reading frames of HPV 16 in cervical carcinoma is associated with poor prognosis. Int. J. Gynecol. Pathol. 17:146-153.
20. Kumala, S. M., S. M. Syrjänen, U. B. Gyllensten, I. P. Shabalova, N. Petrovichev, P. Tosi, K. J. Syrjänen, and B. C. Johansson. 2006. Early integration of high copy HPV16 detectable in women with normal and low grade cervical cytology and histology. J. Clin. Pathol. 59:513-517.
21. Lazo, P. A. 1997. Papillomavirus integration: prognostic marker in cervical cancer? Am. J. Obstet. Gynecol. 176:1121-1122.
22. Li, L. K., M. Dai, G. M. Clifford, W. Q. Yao, A. Arslan, N. Li, J. F. Shi, P. J. Snijders, C. J. Meijer, Y. L. Qiao, and S. Franceschi. 2006. Human papillomavirus infection in Shenyang City, People's Republic of China: a population-based study. Br. J. Cancer 95:1593-1597.
23. Liaw, K. L., A. W. Hsing, M. H. Schiffman, S. L. You, T. Zhang, R. Burk, and C. J. Chen. 1997. Human papillomavirus types 52 and 58 are prevalent in cervical cancer from Chinese women. Int. J. Cancer 73:775-776.
24. Lo, K. W., Y. F. Wong, M. K. Chan, J. C. Li, J. S. Poon, V. W. Wang, S. N. Zhu, T. M. Zhang, Z. G. He, O. L. Wu, G. D. Li, J. S. Tam, T. Kahn, P. Lam, T. H. Cheung, and T. K. Chung. 2002. Prevalence of human papillomavirus in cervical cancer: a multicenter study in China. Int. J. Cancer 100:327-331.
25. Lo, K. W., S. W. Yeung, T. H. Cheung, N. S. Shi, T. Kahn, and Y. F. Wong. 2005. Quantitative analysis of human papillomavirus type 16 in cervical neoplasm: a study in Chinese population. J. Clin. Virol. 34:76-80.
26. Lorincz, A. T., P. E. Castle, M. E. Sherman, D. R. Scott, A. G. Glass, S. Wacholder, B. B. Rush, P. E. Gravitt, J. E. Schussler, and M. Schiffman. 2002. Viral load of human papillomavirus and risk of CIN3 or cervical cancer. Lancet 360:228-229.
27. Moberg, M., I. Gustavsson, E. Wilander, and U. Gyllensten. 2005. High viral loads of human papillomavirus predict risk of invasive cervical carcinoma. Br. J. Cancer 92:891-894.
28. Munoz, N., F. X. Bosch, S. de Sanjose, R. Herrero, X. Castellsague, K. V. Shah, P. J. Snijders, C. J. Meyer, et al. 2003. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med. 348:518-527.
29. Onan, M. A., C. Taskiran, G. Bozdayi, A. Biri, O. Erdem, A. Acar, G. Gunaydin, S. Rota, O. Ataoglu, and H. Guner. 2005. Assessment of human papilloma viral load of archival cervical intraepithelial neoplasia by real-time polymerase chain reaction in a Turkish population. Eur. J. Gynaecol. Oncol. 26:632-635.
30. Park, J. S., E. S. Hwang, S. N. Park, H. K. Ahn, S. J. Um, C. J. Kim, S. J. Kim, and S. E. Namkoong. 1997. Physical status and expression of HPV genes in cervical cancers. Gynecol. Oncol. 65:121-129.
31. Peitsaro, P., B. Johansson, and S. Syrjanen. 2002. Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J. Clin. Microbiol. 40:886-891.
32. Pirami, L., V. Giache, and A. Becciolini. 1997. Analysis of HPV16, 18, 31, and 35 DNA in pre-invasive lesions of the uterine cervix. J. Clin. Pathol. 50:600-604.
33. Romanczuk, H., and P. W. Howley. 1992. Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity. Proc. Natl. Acad. Sci. USA 89:3159-3163.
34. Snijders, P. J., C. J. Hogewoning, A. T. Hesselink, J. Berkhof, F. J. Voorhorst, M. C. Bleeker, and C. J. Meijer. 2006. Determination of viral load thresholds in cervical scrapings to rule out CIN 3 in HPV 16, 18, 31, 33-positive women with normal cytology. Int. J. Cancer 119:1102-1107.
35. Tsai, H. T., C. H. Wu, H. L. Lai, R. N. Li, Y. C. Tung, H. Y. Chuang, T. N. Wu, L. J. Lin, C. K. Ho, H. W. Liu, and M. T. Wu. 2005. Association between quantitative high-risk human papillomavirus DNA load and cervical intraepithelial neoplasm risk. Cancer Epidemiol. Biomarkers Prev. 14:2544-2549.
36. van Duin, M., P. J. Snijders, H. F. Schrijnemakers, F. J. Voorhorst, L. Rozendaal, M. A. Nobbenhuis, A. J. van den Brule, R. H. Verheijen, T. J. Helmerhorst, and C. J. Meijer. 2002. Human papillomavirus 16 load in normal and abnormal cervical scrapes: an indicator of CIN II/III and viral clearance. Int. J. Cancer 98:590-595.
37. Walboomers, J. M., M. V. Jacobs, M. M. Manos, F. X. Bosch, J. A. Kummer, K. V. Shah, P. J. Snijders, J. Peto, C. J. Meijer, and N. Munoz. 1999. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 189:121-129.
38. Wensveen, C. W., M. J. Kagie, N. J. Nagelkerke, R. W. Veldhuizen, and J. B. Trimbos. 2005. Can viral load, semi-quantitatively evaluated, of human papillomavirus predict cytological or histological outcome in women with atypical squamous or glandular cells of undetermined significance cytology? Eur. J. Gynaecol. Oncol. 26:393-397.
39. Woodman, C. B., S. L. Collins, and L. S. Young. 2006. The natural history of cervical HPV infection: unresolved issues. Nat. Rev. Cancer 7:11-12.
40. Ylitalo, N., P. Sorensen, A. M. Josefsson, P. K. Magnussen, P. K. Andersen, J. Ponten, H. O. Adami. U. B. Gyllensten, and M. Melbye. 2000. Consistent high viral load of human papillomavirus 16 and risk of cervical carcinoma in situ: a nested case-control study. Lancet 355:2194-2198.
41. zur Hausen, H. 2002. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2:342-350.