Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 13, 2008, Pages 5236-5241

  Peng, Yi ^a   Chen, Fei ^a   Melamed, Jonathan ^a   Chiriboga, Luis ^a   Wei, Jianjun ^a   Kong, Xiangtian ^a   Mcleod, Maureen ^d   Li, Yirong ^a   Li, Caihong X ^a   Feng, Alice ^a   Garabedian, Michael J ^a   Wang, Zhengxin ^c   Roeder, Robert G ^e   Lee, Peng ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d STATE UNIVERSITY OF NEW YORK   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Mep50; Prostate cancer growth

Indexed keywords

ANDROGEN RECEPTOR; CYCLIN D2; CYCLIN DEPENDENT KINASE 6; PROTEIN P21; PROTEIN P44; ANDROGEN; CCND2 PROTEIN, HUMAN; CYCLINE; P44 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN LNCAP; CONTROLLED STUDY; CYTOPLASM; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TUMOR GROWTH; TUMOR XENOGRAFT; CELL LINE; CELL SEPARATION; ENZYME ACTIVATION; GENETICS; METABOLISM; PROSTATE TUMOR; TUMOR CELL LINE;

MUS;

ANDROGENS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; CYCLIN-DEPENDENT KINASE 6; CYCLINS; CYTOPLASM; ENZYME ACTIVATION; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; TRANSCRIPTION FACTORS;

EID: 42449091048     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712262105     Document Type: Article

References (24)

1. Buchanan G, Irvine RA, Coetzee GA, Tilley WD (2001) Contribution of the androgen receptor to prostate cancer predisposition and progression. Cancer Metastasis Rev 20:207-223.
2. Dehm SM, Tindall DJ (2006) Molecular regulation of androgen action in prostate cancer. J Cell Biochem 99:333-344.
3. Huang H, Tindall DJ (2002) The role of the androgen receptor in prostate cancer. Crit Rev Eukaryotic Gene Expression 12:193-207.
4. Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
5. Whitacre DC, et al. (2002) Androgen induction of in vitro prostate cell differentiation. Cell Growth Differ 13:1-11.
6. Yuan S, et al. (1993) Androgen-induced inhibition of cell proliferation in an androgenin-sensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA. Cancer Res 53:1304-1311.
7. Xu L, Glass CK, Rosenfeld MG (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev 9:140-147.
8. Stallcup MR, et al. (2000) Cooperation between protein-acetylating and protein-methylating coactivators in transcriptional activation. Biochem Soc Trans 28:415-418.
9. Chen H, Lin RJ, Xie W, Hoshino A (1999) Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98:675-686.
10. Li P, et al. (2002) Heterogeneous expression and functions of androgen receptor cofactors in primary prostate cancer. Am J Pathol 161:1467-1474.
11. Taneja SS, et al. (2004) ART-27, an androgen receptor coactivator regulated in prostate development and cancer. J Biol Chem 279:13944-13952.
12. Ueda T, Bruchovsky N, Sadar MD (2002) Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem 277:7076-7085.
13. Muller JM, et al. (2002) The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J 21:736-748.
14. Drobnjak M, Osman I, Scher HI, Fazzari M, Cordon-Cardo C (2000) Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone. Clin Cancer Res 6:1891-1895.
15. Gao S, et al. (2006) Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J Mol Endocrinol 36:463-483.
16. Hosohata K, et al. (2003) Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol Cell Biol 23:7019-7029.
17. Zhou L, Wu H, Lee P, Wang Z (2006) Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells. J Mol Endocrinol 37:283-300.
18. Friesen WJ, et al. (2002) A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem 277:8243-8247.
19. Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K (2006) Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Biochem Biophys Res Commun 345:1051-1058.
20. Licciardo P, et al. (2003) The FCP1 phosphatase interacts with RNA polymerase II, with MEP50 a component of the methylosome complex involved in the assembly of snRNP. Nucleic Acids Res 31:999-1005.
21. Grimmler M, et al. (2005) Phosphorylation regulates the activity of the SMN complex during assembly of spliceosomal U snRNPs. EMBO Rep 6:70-76.
22. Ely S, et al. (2005) Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma. Cancer Res 65:11345-11353.
23. Barry DM, Wente SR (2000) Nuclear transport: Never-ending cycles of signals and receptors. Essays Biochem 36:89-103.
24. Lim DJ, et al. (1993) Growth of an androgen-sensitive human prostate cancer cell line, LNCaP, in nude mice. Prostate 22:109-118.