Sequential causal inference: Application to randomized trials of adaptive treatment strategies

Statistics in Medicine

Volumn 27, Issue 10, 2008, Pages 1626-1645

  Dawson, Ree ^a   Lavori, Philip W ^b  

^a FRONTIER SCIENCE AND TECHNOLOGY RESEARCH FOUNDATION   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptive treatment strategy; Individualized treatments; Multi stage decision problems; Sequential causal inference; Sequential randomization

Indexed keywords

ALGORITHM; ARTICLE; BAYES THEOREM; CALCULATION; CLINICAL DECISION MAKING; CLINICAL PROTOCOL; CLINICAL STUDY; RANDOMIZATION; SIMULATION; STANDARD; STATISTICAL ANALYSIS; VARIANCE;

ALGORITHMS; BAYES THEOREM; CAUSALITY; CONFOUNDING FACTORS (EPIDEMIOLOGY); DECISION SUPPORT TECHNIQUES; DRUG ADMINISTRATION SCHEDULE; HUMANS; MODELS, STATISTICAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STATISTICS, NONPARAMETRIC;

EID: 42449085926     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.3039     Document Type: Article

References (18)

1. Lavori PW, Dawson R. Dynamic treatment regimes: practical design considerations. Clinical Trials 2004; 1:9-20.
2. Murphy S. An experimental design for the development of adaptive treatment strategies. Statistics in Medicine 2005; 24:1455-1481.
3. Thall PF, Millikan RE, Sung HG. Evaluating multiple treatment courses in clinical trials. Statistics in Medicine 2000; 19:1011-1028.
4. Schneider LS, Tariot PN, Lyketsos CG, Dagerman KS, Davis KL, Davis S, Hsiao JK, Jeste DV, Katz IR, Olin JT, Pollock BG, Rabins PV, Rosenheck RA, Small GW, Lebowitz B, Lieberman JA. National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology. American Journal of Geriatric Psychiatry 2001; 9:346-360.
5. Brooner RK, Kidorf M. Using behavioral reinforcement to improve methadone treatment participation. Science and Practice Perspectives 2002; 1:38-48.
6. Rush A, Fava M, Wisniewski S et al. Sequenced Treatment Alternatives to Relieve Depression (STAR*D): rationale and design. Controlled Clinical Trials 2004; 25(1):119-142.
7. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators: effectiveness of antipsychotic drugs in patients with chronic schizophrenia. New England Journal of Medicine 2005; 353: 1286-1288.
8. Lavori PW, Dawson R, Rush AJ. Flexible treatment strategies in chronic disease: clinical and research implications. Biological Psychiatry 2000; 48:605-614.
9. Lavori PW, Rush JA, Wisnewski S et al. Strengthening clinical effectiveness trials: equipoise-stratified randomization. Biological Psychiatry 2001; 50:792-801.
10. Dawson R, Lavori PW. Placebo-free designs for evaluating new mental health treatments: the use of adaptive treatment strategies. Statistics in Medicine 2004; 23:3249-3262.
11. Dawson R, Lavori PW, Luby J, Ryan N, Geller BG. Adaptive strategies for treating childhood mania. Biological Psychiatry 2007; 61:758-764.
12. Dawson R, Lavori PW. comparison of designs for adaptive treatment strategies: classical vs. adaptive randomization. Journal of Statistical Planning & Inference 2003; 117:365-385.
13. Lavori PW, Dawson R. Improving the efficiency of estimation in randomized trials of adaptive treatment strategies. Clinical Trials 2007; in press.
14. Little RJA, Rubin DB. Statistical Analysis with Missing Data. Wiley: New York, 1987.
15. Robins JM. The analysis of randomized and nonrandomized AIDS treatment trials using a new approach to causal inference in longitudinal studies. In Health Service Research Methodology: A Focus on AIDS, Sechrest L, Freeman H, Mulley A (eds). NCHSR, U.S. Public Health Service: Washington, DC, U.S.A. 1989; 113-159.
16. Dawson R, Lavori PW. Using inverse weighting and predictive inference to estimate the effects of time-varying treatments on the discrete-time hazard. Statistics in Medicine 2002; 21:1641-1661.
17. Lavori PW, Dawson R. A design for testing clinical strategies: biased-coin adaptive within-subject randomization. Journal of the Royal Statistical Society, Series A 2000; 163:29-38.
18. Greenhouse JB, Meyer MM. A note on randomization and selection bias in maintenance therapy clinical trials. Psychopharmacology Bulletin 1991; 27:225-229.