Structural studies on desmosomes

Biochemical Society Transactions

Volumn 36, Issue 2, 2008, Pages 181-187

  Al Amoudi, Ashraf ^a   Frangakis, Achilleas S ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Adherens junction; Cadherin; Desmosome; Electron tomography; Vitreous section; X ray crystallography

Indexed keywords

CADHERIN;

AMINO TERMINAL SEQUENCE; CELL ADHESION; CELL INTERACTION; CELL JUNCTION; CONFERENCE PAPER; CRYSTAL STRUCTURE; CYTOSKELETON; DESMOSOME; EPITHELIUM; HEART MUSCLE; IMMUNOELECTRON MICROSCOPY; KERATINOCYTE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURAL PROTEOMICS; WOUND HEALING; X RAY CRYSTALLOGRAPHY;

ANIMALS; CADHERINS; CELL ADHESION; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; CYTOSKELETON; DESMOSOMES; HUMANS; MICROSCOPY, IMMUNOELECTRON; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TOMOGRAPHY;

EID: 42449084561     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360181     Document Type: Conference Paper

References (50)

1. Green, K.J. and Simpson, C.L. (2007) Desmosomes: new perspectives on a classic. J. Invest. Dermatol. 127, 2499-2515
2. Kottke, M.D., Delva, E. and Kowalczyk, A.P. (2006) The desmosome: cell science lessons from human diseases. J. Cell Sci. 119, 797-806
3. Amagai, M., Tsunoda, K., Suzuki, H., Nishifuji, K., Koyasu, S. and Nishikawa, T. (2000) Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J. Clin. Invest. 105, 625-631
4. Huber, O. (2003) Structure and function of desmosomal proteins and their role in development and disease. Cell. Mol. Life Sci. 60, 1872-1890
5. Getsios, S., Huen, A.C. and Green, K.J. (2004) Working out the strength and flexibility of desmosomes. Nat. Rev. Mol. Cell Biol. 5, 271-281
6. 2+- dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. J. Cell Biol. 138, 193-201
7. Marcozzi, C., Burdett, I.D., Buxton, R.S. and Magee, A.I. (1998) Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion. J. Cell Sci. 111, 495-509
8. Tselepis, C., Chidgey, M., North, A. and Garrod, D. (1998) Desmosomal adhesion inhibits invasive behavior. Proc. Natl. Acad. Sci. U.S.A. 95, 8064-8069
9. Runswick, S.K., O'Hare, M.J., Jones, L., Streuli, C.H. and Garrod, D.R. (2001) Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat. Cell Biol. 3, 823-830
10. North, A.J., Bardsley, W.G., Hyam, J., Bornslaeger, E.A., Cordingley, H.C., Trinnaman, B., Hatzleld, M., Green, K.J., Magee, A.I. and Garrod, D.R. (1999) Molecular map of the desmosomal plague J. Cell Sci. 112, 4325-4336
11. Cowin, P., Kapprell, H.P., Franke, W.W., Tamkun, J. and Hynes, R.O. (1986) Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell 46, 1063-1073
12. Chen, X., Bonne, S., Hatzfeld, M., van Roy, F. and Green, K.J. (2002) Protein binding and functional characterization of plakophilin 2: evidence for its diverse roles in desmosomes and β-catenin signaling. J. Biol. Chem. 277, 10512-10522
13. Hatzfeld, M. (2007) Plakophilins: multifunctional proteins or just regulators of desmosomal adhesion? Biochim. Biophys. Acta 1773, 69-77
14. Kowalczyk, A.P., Hatzfeld, M., Bornslaeger, E.A., Kopp, D.S., Borgwardt, J.E., Corcoran, C.M., Settler, A. and Green, K.J. (1999) The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes: implications for cutaneous disease. J. Biol. Chem. 274, 18145-18148
15. Roh, J.Y. and Stanley, J.R. (1995) Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment. J. Invest. Dermatol. 104, 720-724
16. Shapiro, L., Fannon, A.M., Kwong, P.D., Thompson, A., Lehmann, M.S., Grubel, G., Legrand, J.F., Als-Nielsen, J., Colman, D.R. and Hendrickson, W.A. (1995) Structural basis of cell-cell adhesion by cadherins. Nature 374, 327-337
17. Tomschy, A., Fauser, C., Landwehr, R. and Engel, J. (1996) Homophilic adhesion of E-cadherin occurs by a co-operative two-step interaction of N-terminal domains. EMBO J. 15, 3507-3514
18. Nagar, B., Overduin, M., Ikura, M. and Rini, J.M. (1996) Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature 380, 360-364
19. Tamura, K., Shan, W.S., Hendrickson, W.A., Colman, D.R. and Shapiro, L. (1998) Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron 20, 1153-1163
20. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J. 18, 1738-1747
21. Troyanovsky, S. (2005) Cadherin dimers in cell-cell adhesion. Eur. J. Cell Biol. 84, 225-233
22. Boggon, T.J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B.M. and Shapiro, L. (2002) C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296, 1308-1313
23. Pokutta, S., Herrenknecht, K., Kemler, R. and Engel, J. (1994) Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur. J. Biochem. 223, 1019-1026
24. Sivasankar, S., Brieher, W., Lavrik, N., Gumbiner, B. and Leckband, D. (1999) Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains. Proc. Natl. Acad. Sci. U.S.A. 96, 11820-11824
25. Sivasankar, S., Gumbiner, B. and Leckband, D. (2001) Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains. Biophys. J. 80, 1758-1768
26. Chappuis-Flament, S., Wong, E., Hicks, L.D., Kay, C.M. and Gumbiner, B.M. (2001) Multiple cadherin extracellular repeats mediate homophilic binding and adhesion. J. Cell Biol. 154, 231-243
27. Tsukasaki, Y., Kitamura, K., Shimizu, K., Iwane, A.H., Takai, Y. and Yanagida, T. (2007) Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements. J. Mol. Biol. 367, 996-1006
28. Garrod, D. and Chidgey, M. (2007) Desmosome structure, composition and function. Biochim. Biophys. Acta 1778, 572-587
29. He, W., Cowin, P. and Stokes, D.L. (2003) Untangling desmosomal knots with electron tomography. Science 302, 109-113
30. Al-Amoudi, A., Norlen, L.P. and Dubochet, J. (2004) Cryo-electron microscopy of vitreous sections of native biological cells and tissues. J. Struct. Biol. 148, 131-135
31. Al-Amoudi, A., Diez, D.C., Betts, M.J. and Frangakis, A.S. (2007) The molecular architecture of cadherins in native epidermal desmosomes. Nature 450, 832-837
32. Rayns, D.G., Simpson, F.O. and Ledingham, J.M. (1969) Ultrastructure of desmosomes in mammalian intercalated disc: appearances after lanthanum treatment. J. Cell Biol. 42, 322-326
33. Garrod, D.R., Berika, M.Y., Bardsley, W.F., Holmes, D. and Tabernero, L. (2005) Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure. J. Cell Sci. 118, 5743-5754
34. Kimura, T.E., Merritt, A.J. and Garrod, D.R. (2007) Calcium-independent desmosomes of keratinocytes are hyper-adhesive. J. Invest. Dermatol. 127, 775-781
35. Wallis, S., Lloyd, S., Wise, I., Ireland, G., Fleming, T.P. and Garrod, D. (2000) The α isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells. Mol. Biol. Cell 11, 1077-1092
36. Miyaguchi, K. (2000) Ultrastructure of the zonula adherens revealed by rapid-freeze deep-etching. J. Struct. Biol. 132, 169-178
37. Lambert, O., Taveau, J.C., Him, J.L., Al Kurdi, R., Gulino-Debrac, D. and Brisson, A. (2005) The basic framework of VE-cadherin junctions revealed by cryo-EM. J. Mol. Biol. 346, 1193-1196
38. Hewat, E.A., Durmort, C., Jacquamet, L., Concord, E. and Gulino-Debrac, D. (2007) Architecture of the VE-cadherin hexamer. J. Mol. Biol. 365, 744-751
39. Patel, S.D., Chen, C.P., Bahna, F., Honig, B. and Shapiro, L. (2003) Cadherin-mediated cell-cell adhesion: sticking together as a family. Cure Opin. Struct. Biol. 13, 690-698
40. Patel, S.D., Ciatto, C., Chen, C.P., Bahna, F., Rajebhosale, M., Arkus, N., Schieren, I., Jessell, T.M., Honig, B., Price, S.R. and Shapiro, L. (2006) Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell 124, 1255-1268
41. Fleming, T.P., Butler, L., Lei, X., Collins, J., Javed, Q., Sheth, B., Stoddart, N., Wild, A., and Hay, M. (1994) Molecular maturation of cell adhesion systems during mouse early development. Histochemistry 101, 1-7
42. Fleming, T.P., Garrod, D.R. and Elsmore, A.J. (1991) Desmosome biogenesis in the mouse preimplantation embryo. Development 112, 527-539
43. Gumbiner, B., Stevenson, B. and Grimaldi, A. (1988) The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J. Cell Biol. 107, 1575-1587
44. Wheelock, M.J. and Jensen, P.J. (1992) Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin. J. Cell Biol. 117, 415-425
45. Lewis, J.E., Jensen, P.J. and Wheelock, M.J. (1994) Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J. Invest. Dermatol. 102, 870-877
46. Vasioukhin, V., Bauer, C., Yin, M. and Fuchs, E. (2000) Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 100, 209-219
47. Brieher, W.M., Yap, A.S. and Gumbiner, B.M. (1996) Lateral dimerization is required for the homophilic binding activity of C-cadherin. J. Cell Biol. 135, 487-496
48. Yap, A.S., Brieher, W.M., Pruschy, M. and Gumbiner, B.M. (1997) Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr. Biol. 7, 308-315
49. Takeda, H., Shimoyama, Y., Nagafuchi, A. and Hirohashi, S. (1999) E-cadherin functions as a ris-dimer at the cell-cell adhesive interface in vivo. Nat. Struct. Biol. 6, 310-312
50. Chen, C.P., Posy, S., Ben-Shaul, A., Shapiro, L. and Honig, B.H. (2005) Specificity of cell-cell adhesion by classical cadherins: critical role for low-affinity dimerization through β-strand swapping. Proc. Natl. Acad. Sci. U.S.A. 102, 8531-8536