Catalysis of transbilayer lipid migration by hydrophobically modified N-isopropylacrylamide polymers

Langmuir

Volumn 13, Issue 7, 1997, Pages 1869-1872

  Bhattacharya, Soumendu ^a   Moss, Robert A ^a   Ringsdorf, Helmut ^b   Simon, Joachim ^b,c  

^a RUTGERS UNIVERSITY   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 4244087080     PISSN: 07437463     EISSN: None     Source Type: Journal    
DOI: 10.1021/la960992f     Document Type: Article

References (31)

1. Ringsdorf, H.; Schlarb, B.; Venzmer, J. Angew. Chem., Int. Ed. Engl. 1988, 27, 113.
2. Ringsdorf, H.; Sackmann, E.; Simon, J.; Winnik, F. M. Biochim. Biophys. Acta 1993, 1153, 335.
3. Sunamoto, J.; Sato, T.; Taguchi, T.; Hamazaki, H. Macromolecules 1992, 25, 5665.
4. Frankel, D. A.; Lamparski, H.; Liman, U.; O'Brien, D. F. J. Am. Chem. Soc. 1989, 111, 9262.
5. You, H.; Tirrell, D. A. J. Am. Chem. Soc. 1991, 113, 4022.
6. Thomas, J. L.; Tirrell, D. A. Acc. Chem. Res. 1992, 25, 336.
7. Kitano, H.: Kato, N.; Ise, N. J. Am. Chem. Soc. 1989, 111, 6809.
8. Lasic, D., Martin, F., Eds. Stealth Liposomes; CRC Press: Boca Raton, FL, 1995.
9. Review: Singh, A.; Schnur, J. M. In Phospholipids Handbook; Cevc, G., Ed.; Dekker: New York, 1993; pp 233-291.
10. Decher, G.; Kuchinka, E.; Ringsdorf, H.; Venzmer, J.; Bitter-Suermann, D.; Weisgerber, C. Angew. Makromol. Chem. 1989, 166/ 167, 71.
11. (a) Ringsdorf, H.; Venzmer, J.; Winnik, F. M. Angew. Chem.,Int. Ed. Engl. 1991, 30, 315.
12. (b) Ringsdorf, H.; Venzmer, J.; Winnik, F. M. Macromolecules 1991, 24, 1678.
13. Bhattacharya, S.; Moss, R. A.; Ringsdorf, H.; Simon, J. J. Am. Chem. Soc. 1993, 115, 3812.
14. (a) For detailed studies of NIPAM polymers, see: Simon, J. Doctoral Dissertation, Johannes Gutenberg University, Mainz, 1994.
15. (b) For a recent review of NIPAM polymer applications, see: Snowden, M. J.; Murray, M. J.; Chowdry, B. Z. Chem. Ind. (London) 1996, 531.
16. Fujishige, S.; Kubota, K.; Ando, I. Polym. J. (Tokyo) 1990, 22, 15; J. Phys. Chem. 1989, 93, 3311.
17. Fujishige, S.; Kubota, K.; Ando, I. Polym. J. (Tokyo) 1990, 22, 15; J. Phys. Chem. 1989, 93, 3311.
18. The LCST values (°C) as measured by the dependence of turbidity on the temperature of aqueous polymer solutions were 31.8 for 1a, 30.3 for 1b, 31.0 for 1c, 33.0 for 1d, and 30.6 for 1e.
19. Synthetic and other experimental procedures have been published: Moss, R. A.; Okumura, Y. J. Am. Chem. Soc. 1992, 114, 1750.
20. 13
21. 13
22. Homan, R.; Pownall, H. J. J. Am. Chem. Soc. 1987, 109, 4759.
23. O'Leary, T. J. In Cholesterol in Membrane Models; Finegold, L., Ed.; CRC Press: Boca Raton, FL, 1993; pp 175 f. Note that polymer 1c is 1-2 orders of magnitude smaller than the other NIPAM polymers.
24. The lack of cholesterol-induced reequilibration with coliposomes of zwitterionic lipids 2-F/2-NF stands in contrast to the responsiveness of cationic pseudoglyceryl ammonium ion liposomes; Moss, R. A.; Li, J.-M.; Chang, C. J. Am. Chem. Soc. 1993, 115, 10454.
25. See: Finegold, L. Cited in ref 21.
26. (a) Moss, R. A.; Hendrickson, T. F.; Swarup, S.; Hui, Y.; Marky, L.; Breslauer, K. J. Tetrahedron Lett. 1984, 25, 4063.
27. (b) Wistus, E.; Mukhtar, E.; Almgren, M.; Lindquist, S.-E. Langmuir 1992, 8, 1366.
28. (c) Wistus, E.; Mukhtar, E.; Johnansson, L. B.-D. Langmuir 1996, 12, 3371.
29. -4 M in lipid, but the overall polymer loading would become 200 ppm if free polymer transfer occurred.
30. Although flip-flop is not markedly facilitated at 35°C, there is a modest perturbation of the acceptor liposomes upon interaction with the donor liposomes. This is signaled by an initial "jump" in % flip-flop, visible in the polymer transfer experimental point recorded at 0.5 h in Figure 4.
31. Parallel transfer experiments using cholesteryl polymer 1c afford analogous results: flip-flop is not assisted at 35°C but is clearly augmented at 45°C.