Production of recombinant antibodies in transgenic plants

Transgenic Plant Research

Volumn , Issue , 2022, Pages 219-227

  Whitelam, Garry C ^a   Cockburn, William ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Antibodies; Antibody fragments; Plantibodies; Plants; Single chain Fv

Indexed keywords

EID: 4243927227     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (32)

1. v Peisker, M., zur Neiden, U., Fiedler, U., Weiler, E.W., Müntz, K. and Conrad, U. (1995). Expression of a single chain antibody against abscisic acid creates a wilty phenotype in transgenic tobacco. The Plant Journal 8, 745-750.
2. Benvenuto, E., Ordas, R.J., Tavazza, R., Ancora, G., Biocca, S., Cattaneo, A. and Galeffi, P. (1991). "Phytoanti-bodies": a general vector for the expression of immunoglobulin domains in transgenic plants. Plant Molecular Biology, 17, 865-874.
3. Bruyns, A.-M., De Jaeger, G, De Neve, M., De Wilde, C, Van Montagu, M. and Depicker, A. (1996). Bacterial and plant-produced scFv proteins have similar antigen-binding properties. FEBS letters, 386, 5-10.
4. Carlson, J.R. (1988). A new means of inducibly inactivating a cellular protein. Molecular and Cellular Biology, 8, 2638-2646.
5. De Neve, M., De Loose, M., Jacobs, A., Van Houdt, H., Kaluza, B., Weidle, U., Van Montagu, M. and Depicker, A. (1993). Assembly of an antibody and its derived antibody fragment in Nicotiana and Arabidopsis. Transgenic Research, 2, 227-237.
6. De Wilde, C, De Neve, M., De Rycke, R., Bruyns, A.-M., De Jaeger, G, Van Montagu, M., Depicker, A. and Engler, G. (1996). Intact antigen-binding MAK33 antibody and Fab fragment accumulate in intercellular spaces of Arabidopsis thaliana. Plant Science, 114, 233-241.
7. Düring, K., Hippe, S., Kreuzaler, F. and Schell, J. (1990). Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Molecular Biology, 15, 281-293.
8. Fiedler, U. and Conrad, U. (1995). High-level production and long term storage of engineered antibodies in transgenic tobacco seeds. Bio/Technology, 13, 1090-1093.
9. Firek, S., Draper, J., Owen, M.R.L., Gandecha, A., Cock-burn, B. and Whitelam, G.C. (1993). Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures. Plant Molecular Biology, 23, 861-870.
10. Fontes, E.B.P., Shank, B.B., Wrobel, R.L., Moose, S.P., Obrian, G.R., Wurtzel, E.T. and Boston, R.S. (1991). Characterisation of an immunoglobulin binding protein homolog in the maize floury-2 endosperm mutant. Plant Cell, 3, 483-496.
11. Hein, M., Tang, Y., McLeod, D.A., Janda, K.D. and Hiatt, A. (1991). Evaluation of immunoglobulins from plant cells. Biotechnology Progress, 7, 455-461.
12. Hiatt, A., Cafferkey, R. and Bowdish, K. (1989). Production of antibodies in transgenic plants. Nature, 342, 76-78.
13. Hiatt, A. and Ma, J.K.-C. (1992). Monoclonal antibody engineering in plants. FEBS Letters, 307, 71-75.
14. Hiatt, A. and Mostov, K. (1993). Assembly of multimeric proteins in plant cells: Characteristics and uses of plant-derived antibodies. In "Transgenic Plants: Fundamentals and Applications", edited by A. Hiatt, pp. 221-237. New York: Marcel Dekker, Inc.
15. Ma, J.K.-C, Hiatt, A., Hein, M., Vine, D.N., Wang, F., Stabila, P., van Dollerweerd, C, Mostov, K. and Lehner, T. (1995). Generation and assembly of secretory antibodies in plants. Science, 268, 716-719.
16. Ma, J.K.-C, Lehner, T., Stabila, P., Fux, C.I. and Hiatt, T.A. (1994). Assembly of monoclonal antibodies with IgGl and IgA heavy chain domains in transgenic tobacco plants. European Journal of Immunology, 24, 131-138.
17. Maciejewski, J.P., Weichold, F.F., Young, N.S., Cara, A., Zella, D., Reitz, M.S. Jr and Gallo, R.C. (1995). Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro. Nature Medicine, 1, 667-673.
18. Michałek, S.M., Gregory, R.L., Harmon, C.C., Katz, J., Richardson, G.J., Hilton, T., Filler, S.J. and McGhee, J.R. (1987). Protection of gnotobiotic-rats against dental-caries by passive immunisation with bovine-milk antibodies to Streptococcus mutans. Infection and Immunity, 55, 2341-2347.
19. Owen, M., Gandecha, A., Cockburn, B. and Whitelam, G.C. (1992a). Synthesis of a functional anti-phytochrome single-chain Fv protein in transgenic tobacco. Biol Technology, 10, 790-794.
20. Rosso, M.N., Schouten, A., Roosien, J., Borst-Vrenssen, T., Hussey, R.S., Gommers, F.J., Bakker, J., Schots, A. and Abad, P. (1996). Expression and functional characterization of a single chain FV antibody directed against secretions involved in plant nematode infection process. Biochemical and Biophysical Research Communications, 220, 255-263.
21. Schots, A., De Boer, J., Schouten, A., Roosien, J., Zilveren-tant, J.F., Pomp, H., Bouwen-Smits, L., Overmars, H., Gommers, F.J., Visser, B., Stiekema, WJ. and Bakker, J. (1992). "Plantibodies": a flexible approach to design resistance against pathogens. Netherlands Journal of Plant Pathology, 98, 183-191.
22. Sijmons, P.C., Dekker, B.M.M., Schrammeijer, B., Verwoerd, T.C., van den Elzen, P.J.M. and Hoekema, A. (1990). Production of correctly processed human serum albumin in transgenic plants. Bio/Technology, 8, 217-221.
23. Schouten, A., Roosien, J., van Engelen, F.A., de Jong, G.A.M., Borst-Vrenssen, A.W.M., Zilverentant, J.F., Bosch, D., Stiekma, W.J., Gommers, F.J., Schots, A., and Bakker, J. (1996). The C-terminal KDEL sequence increases the expression level of a single chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco. Plant Molecular Biology, 30, 781-793.
24. Stieger, M., Neuhaus, G, Momma, T., Schell, J. and Kreuzaler, F. (1991). Self assembly of immunoglobulins in the cytoplasm of the alga Acetabulars mediterránea. Plant Science, 73, 181-190.
25. Tavladoraki, P., Benvenuto, E., Trinca, S., De Martinis, D., Cattaneo, A. and Galeffi, P. (1993). Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack. Nature, 366, 469-472.
26. van Engelen, F.A., Schouten, A., Molthoff, J.W., Roosien, J., Salinas, J., Dirske, W.G, Schots, A., Bakker, J., Gommers, F.J., Jongsma, M.A., Bosch, D. and Stiekma, W.J. (1994). Coordinate expression of antibody subunit genes yields high levels of functional antibodies in roots of transgenic tobacco. Plant Molecular Biology, 26, 1701-1710.
27. Van Rooijen, G.J.H. and Moloney, M.M. (1995). Structural requirements of oleosin domains for subcellular targeting to the oil body. Plant Physiology, 109, 1353-1361.
28. Voss, A., Niersbach, M., Hain, R., Hirsch, J.H., Liao, Y.C., Kreuzaler, F. and Fischer, R. (1995). Reduced virus infectivity in N. tabacum secreting a TMV-specific full-size antibody. Molecular Breeding, 1, 39-50.
29. Walther-Larsen, H., Brandt, J., Collinge, D.B. and Thordal-Christensen, A. (1993). Pathogen-induced gene of barley encodes a hsp90 homologue showing striking similarity to vertebrate forms resident in the endoplasmic reticulum. Plant Molecular Biology, 6, 1097-1108.
30. Ward, E.S., Gussow, D., Griffiths, A.D., Jones, P.T. and Winter, G. (1989). Binding activities of a repertoire of single Ig variable domains secreted from Escherichia coli. Nature, 341, 544-546.
31. Whitelam, G.C., Cockburn, B., Gandecha, A. and Owen, M.R.L. (1993). Heterologous protein production in transgenic plants. Biotechnology and Genetic Engineering Reviews, 11, 1-29.
32. Winter, G, Griffiths, A.D., Hawkins, R.E. and Hoogen-boom, H.E. (1994). Making antibodies by phage display technology. Annual Review of Immunology, 12, 433-455.