Involvement of nitric oxide synthase and protein kinase C activation on chagasic antibodies action upon cardiac contractility

Molecular and Cellular Biochemistry

Volumn 160-161, Issue , 1996, Pages 75-82

  Sterin Borda, Leonor ^a   Cremaschi, Graciela ^a   Genaro, Ana Maria ^a   Echagüe, Agustina Vila ^a   Goin, Juan Carlos ^a   Borda, Enri ^a  

^a Centre de Estudios Farmacologicos y Botanicos   (Argentina)

Author keywords

Atria contractility; Chagasic IgG; Muscarinic cholinergic receptors; Nitric oxide; Protein kinase C

Indexed keywords

ATROPINE; CARBACHOL; IMMUNOGLOBULIN G ANTIBODY; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; OTENZEPAD; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTOZOON ANTIBODY; STAUROSPORINE;

ADULT; ANIMAL TISSUE; ARTICLE; CHAGAS DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE; HUMAN; INOTROPISM; NONHUMAN; PROTEIN TRANSPORT; RAT;

ANIMALS; ANTIBODIES, PROTOZOAN; ATROPINE; CARBACHOL; CHAGAS CARDIOMYOPATHY; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN G; MYOCARDIAL CONTRACTION; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PARASYMPATHOLYTICS; PIRENZEPINE; PROTEIN KINASE C; RATS;

ANIMALIA; PROTOZOA;

EID: 4243612861     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00240034     Document Type: Article

References (35)

1. WHO Expert Committee: Control of Chagas Disease. Technical report series 811: 1-10, 1991
2. Koberle F: Pathology and pathological anatomy of Chagas disease. Bol. OPS 51: 404-428, 1961
3. Cossio PM, Diez C, Szarfman A, Kreutzer E, Candiolo B, Arana R.M: Chagasic cardiopathy: demonstration of a serum gamma globulin factor which react with endocardium and vascular structures. Circulation 49: 13-21, 1974
4. Acosta A, Santos Buch C. Autoimmune myocarditis induced by T. cruzi. Circulation 71: 1255-1261, 1985
5. Cossio PJ Laguens R, Diez C, Segal A, Arana R: Chagasic cardiomyopathy: Immunologic and morphological studies in myocardial biopsies. Am J Pathol 86: 533-538, 1977
6. Mirkin G, Jones M, Sanz 0, Rey RJ Sica R, Gonzalez Cappa S: Experimental Chagas disease: Electrophysiology and cell composition of the neuromyopathy inflammatory lesions in mice infected with the myotropic and pantropic strain of T. cruzi. Clin Immunol Immunopathol 73: 69-79, 1994
7. Bracco M, Sterin-Borda L, Fink S, Finiasz M, Borda ES: Stimulatory effect of lymphocytes of chagas patients on spontaneously beating rat atria. Clin Exp Immunol 55: 405-412, 1984
8. Gorelik G, Borda ES, Postan M, Gonzalez Cappa SM, Sterin Borda L: T lymphocytes from T. cruzi infected mice alter heart contractility: Participation of arachidonic acid metabolites. J Mol Cell Cardiol 24: 9-20, 1992
9. Sterin-Borda L. Borda ES: Participation of autonomic nerve system in the pathogenesis of Chagas disease. Acta Physiol Phar Ther Latinoan 44: 109-123, 1994
10. Borda ES, Pascual J, Cossio PM, Vega M, Arana RM, Sterin-Borda L: A circulating IgG in Chagas disease which binds to β adrenoceptors of myocardium and modulates its activity. Clin Exp Immunol 57: 679-686, 1984
11. Goin JC, Borda ES, Perez Leiros S, Storino R, Sterin-Borda L: Identification of antibodies with muscarinic cholinergic activity in human Chagas disease: Pathological implications. J Aut Nerv Sys 47: 45-52, 1994
12. Sterin-Borda L, Perez Leiros C, Wald M, Cremaschi G, Borda ES: Antibodies to β1 and β2 adrenoceptors in Chagas disease. Clin Exp Immunol 74: 349-354, 1988
13. Sterin-Borda L, Gorelik G, Borda ES: Chagasic IgG binding with cardiac muscarinic cholinergic receptors modifies cholinergic-mediated cellular transmembrane signals. Clin Immunol Immunopathol 61: 389-397, 1991
14. Cremaschi G, Zwirner N, Gorelik G, Malchiodi E, Charanonte M, Fossati C, Sterin-Borda L: Modulation of cardiac physiology by an anti-Trypanosoma cruzi monoclonal antibody after interaction with myocardium. FASEB J 9: 1995 (in press)
15. Koberle F: Pathogenesis of Chagas disease. In Ciba Foundation Simposium. Assoc Scientific Publishers, Amsterdam, 1974, pp 137-158
16. Iossa D, Dequatro Y, De-Ping-Lee D, Elkayan V, Caeiro T, Palmero H: Pathogenesis of cardiac neuropathy in Chagas disease and the role of autonomic nervous system. J Aut Nerv Sys 30: 583-588, 1990
17. Goin JC, Perez Leiros C, Borda ES, Sterin-Borda L. Human chagasic IgG and muscarinic cholinergic receptor interaction: Pharmacological and molecular evidence. Mol Neuropharm 3: 189-196, 1994
18. Goin J C, Perez Leiros C, Borda E S, Sterin-Borda L: Modification of cholinergic-mediated cellular transmembrane signals by the interaction of human chagasic IgG with cardiac muscarinic receptors. Nero Immuno Modulation 1: 284-291, 1994
19. Gorelik G, Borda ES, Bacman S, Cremaschi G, Sterin-Borda L: Chagasic IgG stimulates phosphoinositide hydrolysis via neurotransmitter receptors activation. Role of calcium. J Lipid Med 5: 249-259, 1992
20. 2 humanos por IgG de pacientes chagasicos. Acta Physiol Pharm Therap Latinoam 44: 145-146, 1994
21. Peres Leiros C, Sterin-Borda L, Vila Echague A, Goin JC, Genaro A, Cremaschi G, Borda ES: Paticipacion del oxido nitrico en el efecto muscarinico cardiaco de la IgG chagasic humana. Medicina 55: S561-S562, 1995
22. Richardson MM, Hosey M: Agonist-independent phosphorylation of purified cardiac muscarinic cholinergic receptor by protein kinase C. Biochemistry 29: 8555-8561, 1990
23. Richardson RM, Ptasienski J, Hosey M: Functional effects of protein kinase C-mediated phosphorylation of chick heart muscarinic cholinergic receptors. J Biol Chem 267: 10127-10132, 1992
24. Van Rossum JM: Cumulative dose-response curve. Arch Int Pharmacodyn Ther 143: 299-330, 1963
25. Bredt DS, Snyder SH: Nitric oxide mediates glutamate-linked enhancement of cyclic GMP levels in the cerebellum. Proc Natl Acad Sci USA 86: 9030-9033, 1989
26. Schulz R, Nava E, Moncada S: Induction and biological relevance of a calcium independent nitric oxide synthase in the myocardium. Br J Pharmacol 105: 575-580, 1992
27. Pascual J, Cossio PM, Borda ES, Arana RM, Sterin-Borda L: Modification of sarcolemmal enzymes by chagasic IgG and its effect on cardiac contractility. Biochem Pharmacol 35: 3839-3845, 1986
28. Balligan JL, Kelly RA, Marsden PA, Smith TW, Michel T: Control of cardiac muscle cell function by an endogenous nitric oxide signalling system. Proc Natl Acad Sci USA 90: 347-351, 1993
29. Sterin-Borda L, Vila Echague A, Perez Leiros C, Genaro A, Borda ES: Endogenous nitric oxide signalling system and the cardiac acetylcholine receptor-inotropic response. Br J Pharmacol 115: 1525-1531, 1995
30. Shah AM, Lewis MJ, Henderson AH: Effects of 8-bromo cyclic GMP on contraction and on inotropic response of ferret cardiac muscle. Mol Cell Cardiol 23: 55-64, 1991
31. Mulsch A, Busse R: N-nitro, L-arginine impairs nitric oxide synthesis from L-arginine. Naunyn Schmiedeberg's Arch Pharmacol 347: 143-147, 1990
32. Stein B, Drogemuller A, Mulsch A, Schmitz W, Scholz H: Calcium-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular myocytes. J Pharm Exp Ther 266: 919-925, 1993
33. Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ: Regulation of transmembrane signalling by receptor phosphorylation. Cell 48: 913-922, 1987
34. Kwatra MM, Hosey MM: Phosphorylation of the cardiac muscarinic receptors in intact chick heart and its regulation by a muscarinic agonist. J Biol Chem 261: 12429-12432, 1986
35. Kwatra MM, Ptasienski J, Hosey MM: The porcine heart M, muscarinic receptor agonist-induced phosphorylation and comparison properties with the chicken heart receptor. Mol Pharmacol 35: 553-558, 1989