Influence of the pK(a) value of the buried, active-site cysteine on the redox properties of thioredoxin-like oxidoreductases

FEBS Letters

Volumn 477, Issue 1-2, 2000, Pages 21-26

  Mössner, Ekkehard ^a   Iwai, Hideo ^a   Glockshuber, Rudi ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Disulfide exchange reaction; pK(a) value; Redox potential; Thiol disulfide oxidoreductase; Thioredoxin

Indexed keywords

OXIDOREDUCTASE; RECOMBINANT ENZYME; THIOREDOXIN;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; OXIDATION REDUCTION POTENTIAL; PKA; PRIORITY JOURNAL; PROTEIN VARIANT;

ALKYLATION; BINDING SITES; CATALYSIS; CIRCULAR DICHROISM; CONSENSUS SEQUENCE; CYSTEINE; DISULFIDES; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; OXIDATION-REDUCTION; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); RECOMBINANT PROTEINS; THERMODYNAMICS; THIOREDOXIN; TITRIMETRY; VARIATION (GENETICS);

EID: 4243518910     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01738-5     Document Type: Article

References (32)

1. Holmgren A., Björnstedt B. Methods Enzymol. 252:1995;199-209.
2. Martin J.L. Structure. 3:1995;245-250.
3. Grauschopf U., Winther J.R., Korber P., Zander T.P., Dallinger P., Bardwell J.C.A. Cell. 83:1995;947-955.
4. Huber-Wunderlich M., Glockshuber R. Fold. Des. 3:1998;161-171.
5. Mössner E., Huber-Wunderlich M., Glockshuber R. Protein Sci. 7:1998;1233-1244.
6. Hol W.G.J. Prog. Biophys. Mol. Biol. 45:1985;149-195.
7. Jeng M.F., Holmgren A., Dyson H.J. Biochemistry. 34:1995;10101-10105.
8. Gane P.J., Freedman R.B., Warwicker J. J. Mol. Biol. 249:1995;376-387.
9. Kortemme T., Darby N.J., Creighton T.E. Biochemistry. 35:1996;14503-14511.
10. Nelson J.W., Creighton T.E. Biochemistry. 33:1994;5974-5983.
11. Szajewski R.P., Whitesides G.M. J. Am. Chem. Soc. 102:1980;2011-2026.
12. Dyson H.J., Jeng M.F., Tennant L.L., Slaby I., Lindell M., Cui D.S., Kuprin S., Holmgren A. Biochemistry. 36:1997;2622-2636.
13. Kallis G.B., Holmgren A. J. Biol. Chem. 255:1980;10261-10265.
14. Li H., Hanson C., Fuchs J.A., Woodward C., Thomas G.J.J. Biochemistry. 32:1993;5800-5808.
15. Vohnik S., Hanson C., Tuma R., Fuchs J.A., Woodward C., Thomas G.J. Jr. Protein Sci. 7:1998;193-200.
16. Takahashi N., Creighton T.E. Biochemistry. 35:1996;8342-8353.
17. Chivers P.T., Prehoda K.E., Volkman B.F., Kim B.M., Markley J.L., Raines R.T. Biochemistry. 36:1997;14985-14991.
18. Müller S., Senn H., Gsell B., Vetter W., Baron C., Böck A. Biochemistry. 33:1994;3404-3412.
19. Griffey R.H., Redfield A.G. Biochemistry. 24:1985;817-822.
20. Riesenberg D., Menzel K., Schulz V., Schumann K., Veith G., Zuber G., Knorre W.A. Appl. Microbiol. Biotechnol. 34:1990;77-82.
21. Markley J.L., Bax A., Arata Y., Hilbers C.W., Kaptein R., Sykes B.D., Wright P.E., Wüthrich K. Pure Appl. Chem. 70:1998;117-142.
22. Güntert P., Dötsch V., Wider G., Wüthrich K. J. Biomol. NMR. 2:1992;619-629.
23. Bartels C., Xia T., Billeter M., Güntert P., Wüthrich K. J. Biomol. NMR. 6:1995;1-10.
24. LeMaster D.M. Biochemistry. 35:1996;14876-14881.
25. Dyson H.J., Gippert G.P., Case D.A., Holmgren A., Wright P.E. Biochemistry. 29:1990;4129-4136.
26. Jung G., Breitmeier E., Voelter W. Eur. J. Biochem. 24:1972;438-445.
27. Rost J., Rapoport D. Nature. 201:1964;185.
28. Chivers P.T., Prehoda K.E., Raines R.T. Biochemistry. 36:1997;4061-4066.
29. Wunderlich M., Otto A., Maskos K., Mücke M., Seckler R., Glockshuber R. J. Mol. Biol. 247:1995;28-33.
30. Nordstrand K., Åslund F., Meunier S., Holmgren A., Otting G., Berndt K.D. FEBS Lett. 449:1999;196-200.
31. Creighton, T.E. (1993) in: Proteins: Strucutres and Molecular Properties, pp. 162-165, Freeman, New York.
32. Kirby A.J. Adv. Phys. Org. Chem. 17:1980;183-278.