Design and fabrication of a sonophoresis device with a flat flextensional transducer for transdermal drug delivery

Sensors and Actuators, A: Physical

Volumn 115, Issue 1, 2004, Pages 133-139

  Zhang, H Y ^a   Yeo, S H ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Flat flextensional transducer; Sonophoresis device; Transdermal drug delivery system; Ultrasound

Indexed keywords

COMPUTER SIMULATION; DRUG PRODUCTS; FINITE ELEMENT METHOD; KINETIC ENERGY; METABOLISM; THICKNESS MEASUREMENT; ULTRASONICS;

FLAT FLEXTENSIONAL TRANSDUCERS; SONOPHORESIS DEVICE; TRANSDERMAL DRUG DELIVERY SYSTEM;

TRANSDUCERS;

EID: 4243140505     PISSN: 09244247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sna.2004.04.018     Document Type: Article

References (20)

1. P.M. Elias, The microscopic structure of the epidermis and its derivatives, in: R.L. Bronaugh, H.I. Maibach (Eds.), Percutaneous Absorption: Mechanisms - Methodology - Drug Delivery, Marcel Dekker, New York, 1989.
2. Johnson M.E., Mitragotri S., Patel A., Blankschtein D., Langer R. Synergistic effect of ultrasound and chemical enhancers on transdermal drug delivery. J. Pharmaceut. Sci. 85:1996;670-679.
3. P.G. Green, M. Flalagan, B. Shroot, R.H. Guy, Iontophoretic drug delivery, in: K.A. Walters, J. Hadgraft (Eds.), Pharmaceutical Skin Penetration Enhancement, Marcel Dekker, New York, 1993.
4. Prausniz M.R., Bose V., Langer R., Weaver J.C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl. Acad. Sci. 90:1993;10504-10508.
5. Tezel A., Sens A., Tuchscherer J., Mitragotri S. Frequency dependence of sonophoresis. Pharmaceut. Res. 18(12):2001;1694-1700.
6. Mitragotri S., Edwards D.A., Blankschtein D., Langer R. A mechanical study of ultrasonically enhanced transdermal drug delivery. J. Pharmaceut. Sci. 84:1995;697-706.
7. Mitragotri S., Blankschtein D., Langer R. An explanation for variation of the sonophoretic transdermal transport enhancement from drug to drug. J. Pharmaceut. Sci. 86:1997;1190-1192.
8. J.E. Ogden, Sonophoresis drug delivery system, US Patent 5,656,016, 1997.
9. Sontra Medical Inc., Sontra™, http://www.sontra.com/technology/nooninvasivedevice/, 30 March 2004.
10. J. Shimada, J.E. Shapland, Drug delivery by multiple frequency phonophoresis, US Patent 5,267,985, 1993.
11. R.T. Bock, Ultrasonic method and apparatus for cosmetic and dermatological applications, US Patent 5,618,275, 1997.
12. Denkmann W.J., Nickell R.E., Stickler D.C. Analysis of structure-acoustic interactions in metal-ceramic transducers. IEEE Trans. Audio Electroacoustics. AU-21(4):1973;317-323.
13. W.J. Hughes, Encyclopedia of Applied Physics, vol. 22, Wiley/VCH, New York, 1998.
14. Mitragotri S., Farrell J., Tang H., Terahara T., Kost J., Langer R. Determination of threshold energy dose for ultrasound-induced transdermal drug transport. J. Controlled Release. 63:2000;41-52.
15. Mitragotri S., Blankschtein D., Langer R. Ultrasound mediated transdermal protein delivery. Science. 269:1995;850-853.
16. Kwak M.K. Vibration of circular plates in contact with water. Trans. ASME. 58:1991;480-483.
17. ANSYS Coupled Field Analysis Guide, ANSYS Release 6.0, ANSYS Inc., Canonsburg, PA, 2001.
18. Katz B.F.G. Acoustic absorption measurement of human hair and skin within the audible frequency range. J. Acoustic Soc. Am. 108(5):2000;2238-2242.
19. K.S. Suslick, Ultrasound its Chemical, Physical, and Biological Effects, VCH, New York, 1988.
20. IEEE Standard Boar, IEEE Guide for Medical Ultrasound Field Parameter Measurements, Institute of Electrical and Electronics Engineers Inc., New York, 1989.