Skewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriage

Fetal Diagnosis and Therapy

Volumn 23, Issue 3, 2008, Pages 198-203

  Dasoula, A ^a   Kalantaridou, S ^a   Sotiriadis, A ^a   Pavlou, M ^a   Georgiou, I ^a   Paraskevaidis, E ^a   Makrigiannakis, A ^b   Syrrou, M ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

Androgen receptor; Methylation; Recurrent miscarriage; Skewed X chromosome inactivation

Indexed keywords

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROL GROUP; CONTROLLED STUDY; FEMALE; GREECE; HUMAN; MAJOR CLINICAL STUDY; MEDICAL INFORMATION; METHYLATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; X CHROMOSOME INACTIVATION;

ABORTION, HABITUAL; ADULT; CASE-CONTROL STUDIES; FEMALE; GREECE; HETEROZYGOTE; HUMANS; MALE; ODDS RATIO; POLYMERASE CHAIN REACTION; PREGNANCY; PROSPECTIVE STUDIES; RECEPTORS, ANDROGEN; X CHROMOSOME INACTIVATION;

EID: 42349101246     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000116741     Document Type: Article

References (18)

1. Lanasa MC, Hogge WA, Hoffman EP: The X chromosome and recurrent spontaneous abortion: the significance of transmanifesting carriers. Am J Hum Genet 1999;64:934-938.
2. Migeon BR, Moser HW, Moser AB, Axelman G, Sillence D, Norum RA: Adrenoleukodystrophy: evidence for X linkage, inactivation, and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci USA 1981;78:5066-5070.
3. Gale RE, Fielding AK, Harrison CN, Linch DC: Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age. Br J Haematol 1997;98:512-519.
4. Plenge RM, Hendrich BD, Schwartz C, Arena JF, Naumova A, Sapienza C, Winter RM, Willard HF: A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation. Nat Genet 1997;17:353-356.
5. American College of Obstetricians and Gynecologists ACOG Practice Bulletin: No 24, Management of recurrent early pregnancy loss. Int J Gynecol Obstet 2002;78:179-190.
6. Sangha KK, Stephenson MD, Brown CJ, Robinson WP: Extremely skewed X-chromosome inactivation is increased in women with recurrent spontaneous abortion (Letter to the editor). Am J Hum Genet 1999;65:913-917.
7. Uehara S, Hashiyada M, Sato K, SatoY, Fujimori K, Okamura K: Preferential X-chromosome inactivation in women with idiopathic recurrent pregnancy loss. Fertil Steril 2001;76:908-914.
8. Suzuki Y, Sasagawa I, Tateno T, Ashida J, Nakada T, Muroya K, Ogata T: Mutation screening and CAG repeat length analysis of the androgen receptor gene in Klinefelter' syndrome patients with and without spermatogenesis. Hum Reprod 2001;16:1653-1656.
9. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW: Methylation of Hpa II and Hha I sites near the polymorphic CAG repeat in the human androgen receptor gene correlates with X-chromosome inactivation. Am J Hum Genet 1992;51:1229-1239.
10. Lau AW, Brown CJ, Penaherrera M, Langlois S, Kalousek DK, Robinson WP: Skewed Xchromosome inactivation is common in fetuses or newborns associated with confined placental mosaicism. Am J Hum Genet 1997;61:1353-1361.
11. Lanasa MC, Hogge WA, Kubic CJ, Ness RB, Harger J, Nagel T, Prosen T, Markovik N, Hoffman EP: A novel X-linked genetic cause of recurrent spontaneous abortion. Am J Obstet Gynecol 2001;185:563-568.
12. Sullivan AE, Lewi T, Stephenson M, Odem R, Schreiber J, Ober C, Branch DW: Pregnancy outcome in recurrent miscarriage patients with skewed X- chromosome inactivation. Obstet Gynecol 2003;101:1236-1241.
13. Pääbo S: The Y chromosome and the origin of all of us (men). Science 1995;268:1141-1142.
14. Beever CL, Stephenson MD, Penaherrera MS, Jiang RH, Kalousek DK, Hayden M, Field L, Brown CJ, Robinson WP: Skewed X-chromosome inactivation is associated with trisomy in women ascertained on the basis of recurrent spontaneous abortion or chromosomally abnormal pregnancies. Am J Hum Genet 2003;72:399-407.
15. Kim JW, Park SY, Kim YM, Kim JM, Han JY, Ryu HM: X-chromosome inactivation patterns in Korean Women with idiopathic recurrent spontaneous abortion. J Korean Med Sci 2004;19:258-262.
16. Pegoraro E, Whitaker J, Mowery-Rushton P, Surti U, Lanasa M, Hoffman EP: Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28. Am J Hum Genet 1997;61:160-170.
17. Busque L, Moi R, Mattioli J, Brais E, Blais N, Lalonde Y, Maragh M, Gilliland DG: Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Blood 1996;88:59-65.
18. Sharp A, Robinson D, Jacobs P: Age- and tissue-specific variation of X chromosome inactivation ratios in normal women. Hum Genet 2000;107:343-349.