UBE1L represses PML/RARα by targeting the PML domain for ISG15ylation

Molecular Cancer Therapeutics

Volumn 7, Issue 4, 2008, Pages 905-914

  Shah, Sumit J ^a   Blumen, Steven ^a   Pitha Rowe, Ian ^a   Kitareewan, Sutisak ^a   Freemantle, Sarah J ^a   Feng, Qing ^a   Dmitrovsky, Ethan ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERFERON STIMULATED GENE 15 PRODUCT; N ACETYL LEUCINYL LEUCINYL NORLEUCINAL; PROTEASOME INHIBITOR; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E1 LIKE; UBIQUITIN SPECIFIC PROTEASE 18; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; ENZYME DEGRADATION; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; UBIQUITINATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BRONCHI; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOKINES; ENDOPEPTIDASES; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LEUKEMIA, PROMYELOCYTIC, ACUTE; LEUPEPTINS; ONCOGENE PROTEINS, FUSION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; TRETINOIN; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINS;

EID: 42249115843     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0515     Document Type: Article

References (31)

1. Frankel SR, Miller WH, Jr., Dmitrovsky E. Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia. Oncology 1992;6:74-8.
2. Xiao YH, Miller WH, Jr., Warrell RP, Dmitrovsky E, Zelenetz AD. Pulsed-field gel electrophoresis analysis of retinoic acid receptor-α and promyelocytic leukemia rearrangements. Detection of the t(15;17) translocation in the diagnosis of acute promyelocytic leukemia. Am J Pathol 1993;143:1301-11.
3. Kakizuka A, Miller WH, Jr., Umesono K, et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 1991;66:663-74.
4. Warrell RP, Jr., Frankel SR, Miller WH, Jr., et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all -trans-retinoic acid). N Engl J Med 1991;324:1385-93.
5. Yoshida H, Kitamura K, Tanaka K, et al. Accelerated degradation of PML-retinoic acid receptor α (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res 1996;56:2945-8.
6. Mani A, Gelmann EP. The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 2005;23:4776-89.
7. Welchman RL, Gordon C, Mayer RJ. Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol 2005;6:599-609.
8. Staub O. Ubiquitylation and isgylation: overlapping enzymatic cascades do the job. Sci STKE 2004;245:pe43.
9. Yuan W, Krug RM. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. EMBO J 2001;20:362-71.
10. Zhao C, Beaudenon SL, Kelley ML, et al. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein. Proc Natl Acad Sci U S A 2004;101:7578-82.
11. Zou W, Zhang DE. The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J Biol Chem 2006;281:3989-94.
12. Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem 2002;277:9976-81.
13. Nason-Burchenal K, Dmitrovsky E. The retinoids: cancer therapy and prevention mechanisms. In: Nau H, Blaner WS, editors. Handbook of experimental pharmacology. Vol. 139. Heidelberg: Springer-Verlag; 1999. p. 301-22.
14. Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 2003;22:7305-15.
15. Miller WH, Jr., Kakizuka A, Frankel SR, et al. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc Natl Acad Sci U S A 1992;89:2694-8.
16. Nervi C, Ferrara FF, Fanelli M, et al. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARα fusion protein. Blood 1998;92:2244-51.
17. Zhu J, Gianni M, Kopf E, et al. Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor (RAR) and oncogenic RAR fusion proteins. Proc Natl Acad Sci U S A 1999;96:14807-12.
18. Kitareewan S, Pitha-Rowe I, Sekula D, et al. UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia. Proc Natl Acad Sci U S A 2002;99:3806-11.
19. Pitha-Rowe I, Hassel BA, Dmitrovsky E. Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. J Biol Chem 2004;279:18178-87.
20. Freemantle SJ, Portland HB, Ewings K, et al. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. Gene 2002;291:17-27.
21. Dragnev KH, Pitha-Rowe I, Ma Y, et al. Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. Clin Cancer Res 2004;10:2570-7.
22. Feng Q, Sekula D, Muller R, Freemantle SJ, Dmitrovsky E. Uncovering residues that regulate cyclin D1 proteasomal degradation. Oncogene. Epub 2007 Feb 19.
23. Liu M, Li XL, Hassel BA. Proteasomes modulate conjugation to the ubiquitin-like protein, ISG15. J Biol Chem 2003;278:1594-602.
24. Pitha-Rowe I, Petty WJ, Feng Q, et al. Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention. Cancer Res 2004;64:8109-15.
25. Desai SD, Haas AL, Wood LM, et al. Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res 2006;66:921-8.
26. Pitha-Rowe I, Petty WJ, Kitareewan S, Dmitrovsky E. Retinoid target genes in acute promyelocytic leukemia. Leukemia 2003;17:1723-30.
27. 3-induced PML or PML/retinoic acid receptor α degradation. J Exp Med 2001;193:1361-71.
28. Kamitani T, Nguyen HP, Kito K, Fukuda-Kamitani T, Yeh ET. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. J Biol Chem 1998;273:3117-20.
29. Nason-Burchenal K, Gandini D, Botto M, et al. Interferon augments PML and PML/RAR α expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood 1996;88:3926-36.
30. Dao CT, Luo, JK, Zhang DE. Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction. Blood Cells Mol Dis 2006;36:406-13.
31. Malakhova OA, Kim KI, Luo JK, et al. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J 2006;25:2358-67.