Study of forced-acid/heat degradation and degradant/impurity profile of phenazopyridine hydrochloride through HPLC and spectrofluorimetric analyses

Journal of Food and Drug Analysis

Volumn 16, Issue 1, 2008, Pages 56-65

  Sabry, Suzy M ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Forced acid heat degradation; Impurity; Phenazopyridine HC1; Spectrofluorimetry; Stability indicating HPLC assay

Indexed keywords

2,6 DIAMINOPYRIDINE; ACETIC ACID; ACETONITRILE; ACID; PHENAZOPYRIDINE; PHENOL; UNCLASSIFIED DRUG; URISEPT;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG IMPURITY; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; REFERENCE VALUE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; SPECTROFLUOROMETRY; TABLET; THERMAL EXPOSURE; THERMOSTABILITY;

EID: 42249110541     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Parfitt, K., Sweetman, S. C., Blake, P. S. and Parsons, A. V. 2005. Martindale - The Extra Pharmacopoeia. 34th ed. p. 83. Pharmaceutical Press. London, U. K.
2. Palabiyik, I. M. and Onur, F. 2004. Liquid chromatographic and spectrophotometric determination of phenazopyridine hydrochloride, ampicillin trihydrate and nitrofurantoin in pharmaceutical preparations. Anal. Lett. 37: 2125-2150.
3. Belal, F. 1988. Simultaneous high performance liquid chromatographic determination of phenazopyridine and nitrofurantoin in tablets. Chromatographia 25: 61-63.
4. Du Preez, J. L., Botha, S. A. and Lotter, A. P. 1985. High performance liquid chromatographic determination of phenazopyridine hydrochloride, tetracycline hydrochloride and sulfamethizole in combination. J. Chromatogr. 333: 249-252.
5. Erk, N. and Gonullu, U. G. 2002. Resolution of two-component mixtures in pharmaceutical formulations containing phenazopyridine hydrochloride by ratio spectra derivative spectrophotometry. Anal. Lett. 35: 83-98.
6. Ribone, M. E., Pagani, A. P. and Olivieri, A. C. 1999. Simultaneous multivariate spectrophotometric analysis of binary and ternary mixtures of sulfamethoxazole, trimethoprim and phenazopyridine in tablets. Anal. Lett. 32: 1389-1401.
7. Walash, M. I., El-Brashy, A. M., El-Din, M. S., Abuirjeie, M. A. and El-Rahman Sultan, M. A. 1994. Zero-crossing first derivative spectrophotometry for the simultaneous determination of phenazopyridine and nitrofurantoin in tablets. Pharmazie 49: 698-699.
8. Surmann, P. and Aswakun, P. 1985. Simultaneous polarographic determination of nitrofurantoin and phenazopyridine in tablets. Arch. Pharm. 318: 14-21.
9. The United States Pharmacopeia (USP 28) and The National Formulary 23. 2005. pp. 1523-1524. Pharmacopeial convention Inc. U. S. A.
10. Nickerson, B., Scypinski, S., Sokoloff, H. and Sahota, S. 1995. Separation of sulfisoxazole, phenazopyridine and their related impurities by micellar electrokinetic chromatography. J. Liq. Chromatogr. 18: 3847-3875.
11. Iqbal, J., Gupta, A. and Husain, A. 2006. Photochemistry of phenazopyridine hydrochloride. Pharmazie 61: 747-750.
12. Gennaro Alfonso, R. 1990. Remington's Pharmaceutical Sciences. 18th ed. p. 1169. Mack printing company. U. S. A.
13. Sabry Suzy, M. 1999. Adsorptive stripping voltammetric assay of phenazopyridine hydrochloride in biological fluids and pharmaceutical preparations. Talanta 50: 133-140.