Maximizing association statistics over genetic models

Genetic Epidemiology

Volumn 32, Issue 3, 2008, Pages 246-254

  González, Juan R ^a,c,g   Carrasco, Josep L ^c   Dudbridge, Frank ^d   Armengol, Lluís ^b,e   Estivill, Xavier ^b,e   Moreno, Victor ^f  

^a CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d MRC BIOSTATISTICS UNIT   (United Kingdom)

^e CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^f BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^g Barcelona Biomedical Research Park   (Spain)

Author keywords

Genetic models; Max statistic; Mode of inheritance; Power

Indexed keywords

ALLELE; ARTICLE; CALCULATION; CONTROLLED STUDY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC MODEL; GENOTYPE; HUMAN; MONTE CARLO METHOD; STATISTICAL SIGNIFICANCE;

COMPUTER SIMULATION; DATABASES, GENETIC; GENES, DOMINANT; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, GENETIC; MODELS, STATISTICAL;

EID: 42249096145     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20299     Document Type: Article

References (18)

1. Agresti A. 2002. Categorical Data Analysis. New York: Wiley.
2. Armitage P. 1955. Tests for linear trends in proportions and frequencies. Biometrics 11:375-386.
3. Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB. 2007. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80:273-290.
4. Chapman DG, Nam JM. 1968. Asymptotic power of chi square tests for linear trends in proportions. Biometrics 24:315-327.
5. Cordell HJ, Clayton DG. 2002. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to hla in type 1 diabetes. Am J Hum Genet 70:124-141.
6. Freidlin B, Zheng G, Li Z, Gastwirth JL. 2002. Trend tests for case-control studies of genetic markers: power, sample size and robustness. Hum Hered 53:146-152.
7. Genz A. 1992. Numerical computation of multivariate normal probabilities. J Comput Graphical Stat 1:141-150.
8. Gonzalez JR, Armengol L, Sole X, Guino E, Mercader JM, Estivill X, Moreno V. 2007. SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23:654-655.
9. Guenther WC. 1977. Power and sample size for approximate chisquare tests. Am Stat 31:83-85.
10. Milne RL, Ribas G, Gonzalez-Neira A, Fagerholm R, Salas A, Gonzalez E, Dopazo J, Nevanlinna H, Robledo M, Benitez J. 2006. ERCC4 associated with breast cancer risk: a two-stage case-control study using high-throughput genotyping. Cancer Res 66:9420-9427.
11. Pooley KA, Healey CS, Smith PL, Pharoah PD, Thompson D, Tee L, West J, Jordan C, Easton DF, Ponder BA, Dunning AM. 2006. Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach. Cancer Epidemiol Biomarkers Prev 15:675-682.
12. Puig P. 1998. A note on testing segregation between two groups of animals using entropy. Biometrical J 40:155-163.
13. Schaid DJ, McDonnell SK, Hebbring SJ, Cunningham JM, Thibodeau SN. 2005. Nonparametric tests of association of multiple genes with human disease. Am J Hum Genet 76:780-793.
14. Serfling RJ. 1980. Approximation Theorems of Mathematical Statistics. New York: Wiley.
15. Sidàk Z. 1967. Rectangular confidence region for the means of multivariate normal distributions. J Am Stat Assoc 62:626-633.
16. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P. 2007. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885.
17. Slager SL, Schaid DJ. 2001. Case-control studies of genetic markers: power and sample size approximations for Armitage's test for trend. Hum Hered 52:149-153.
18. Wang K, Sheffield VC. 2005. A constrained-likelihood approach to marker-trait association studies. Am J Hum Genet 77:768-780.