Enhancing transdermal drug delivery with electroporation

Recent Patents on Drug Delivery and Formulation

Volumn 2, Issue 1, 2008, Pages 51-57

  Wong, Tak Wah ^a   Ko, Shu Fen ^a   Hui, Sek Wen ^b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Assembly; Electrochemotherapy; Electrode; Electrogenetherapy; Electroporation; Microfabrication; Needle free; Painless; Skin; Transcutaneous permeation; Transdermal delivery

Indexed keywords

ALCOHOL; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BIOGENIC AMINE; BLEOMYCIN; DNA VACCINE; DODECYL SULFATE SODIUM; LIPOSOME; LOCAL ANESTHETIC AGENT; MYDRIATIC AGENT; MYRISTIC ACID ISOPROPYL ESTER; OLEIC ACID; PEPTIDE DERIVATIVE; PEPTIDE HORMONE; PHOSPHOLIPID; POLOXAMER; PROTEIN DERIVATIVE; RNA VACCINE; VACCINE; VINCA ALKALOID;

DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; ELECTRIC FIELD; ELECTROCHEMOTHERAPY; ELECTRODE; ELECTROPORATION; ENCAPSULATION; GENE DELIVERY SYSTEM; GEOMETRY; HUMAN; HYPERTHERMIA; INTERSTITIAL FLUID; IONTOPHORESIS; NONHUMAN; PAIN; PATENT; PRIORITY JOURNAL; REVIEW; RNA INTERFERENCE; SKIN PERMEABILITY; SKIN TUMOR; SUBCUTANEOUS TISSUE TUMOR; SYRINGE; THERMOREGULATION; TRANSDERMAL DRUG ADMINISTRATION; ULTRASOUND; VAPORIZATION; VIBRATION;

ADMINISTRATION, CUTANEOUS; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; ELECTRODES; ELECTROPORATION; EXTRACELLULAR FLUID; HUMANS; PAIN; PATENTS AS TOPIC; PHARMACEUTICAL PREPARATIONS; SKIN ABSORPTION; SYRINGES;

EID: 42249093179     PISSN: 18722113     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221108783331393     Document Type: Review

References (63)

1. Chang DC, Chassy BM, Saunders JA, Sowers A. eds. Guide to Electroporation and Electrofusion. New York, Academic Press 1992.
2. Jaroszeski MJ, Heller R, Gilbert R. Electrically mediated delivery of molecules to cells: electrochemotherapy, electrogenetherapy and transdermal drug delivery. Totowa, N.J., Humana Press, 1999.
3. Prausnitz MR, Mitragotri, S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev 2004; 3:115-24.
4. Denet AR, Vanbever R, Preat V. Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev 2004; 56: 659-674.
5. Prausnitz MR, Bose VG, Longer R, Weaver JC. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc Natl Acad Sci USA 1993; 90:10504-08.
6. Gallo SA, Oseroff AR, Johnson PG, Hui SW. Characterization of electricpulse-induced permeabilization of porcine skin using surface electrodes. Biophys J 1997; 72: 2805-11.
7. Sen A, Zhao YL, Hui SW. Saturated anionic phospholipids enhance transdermal transport by electroporation. Biophys J 2002; 83: 2064-73
8. Pliquett, U, Gallo, SA, Hui, SW, Gusbeth, Ch, Neumann, E. Local and transient structural changes in stratum corneum at high electric field: Contribution of joule heating. Bioelectrochemistry 2005; 67:37-46.
9. Murthy SN, Sen A, Zhao YL, Hui SW. pH Influences the post pulse permeability state of skin after electroporation. J Control Release 2003; 93: 49-57.
10. Schoenbach, K.H., Beebe, SJ., Buescher, E.S.: US20016326177 (2001).
11. Gundersen, M.A., Puchkarev, V., Yampolsky, J: US5603893 (1997).
12. Hui, SW. Overview of drug delivery and alternative methods to electroporation. In: Shulin Li, Ed., Electroporation Protocols: Experimental and Clinical Medicine, Methods in Molecular Biology. Totowa, NJ, Humana Press, 2007. (in press).
13. Hofmann, G.A.: US5439440 (1995).
14. Weaver, J.C., Powell, K.T., Langer, R.S. Jr.: US5019034 (1991).
15. Pliquett, U., Prausnitz, M.R., Weaver, J.C,, Langer, R.S.: US5547467 (1996).
16. Hofmann, G.A., Zhang, L.: US5688233 (1997).
17. Wong TW, Chen CH, Huang CC, Lin CD, Hui SW. Painless electroporation with a new needle-free microelectrode array to enhance transdermal drug delivery. J Control Release 2006; 110: 557-65.
18. Weaver, J.C., Pliquett, U., Vaughan, T.: US5983131 (1999).
19. Zhang, L., Hofmann, G.A.: WO002620 (1999).
20. Mori, K., Nozawa, L, Sato, S.: US20056978172 (2005).
21. Bernabei, G.F.: US20067083580 (2006).
22. Bernabei, G.F.: US20046748266 (2004).
23. Jaroszeski, MJ., Gilbert, K, Heller, R.: US20056937890 (2005).
24. Jaafar, A., Chornenky, V.I.: US20056892099 (2005).
25. Eppstein, J.A.: US20036527716 (2003).
26. Eppstein, J.A., Hatch, M.R., Yang, D.: US20006142939 (2000).
27. Avrahami, Z.: US20067121457 (2006).
28. Weaver, J.C.: US5389069 (1995).
29. Hofmann, G.A.: US5318514 (1994).
30. Hofmann G.A., Rabussay, D.P., Zhang, L.: US20036520950 (2003).
31. King, A.D., Walters, R.E.: US20036603998 (2003).
32. Seward, K.P.: US20067127284 (2006).
33. Sen, A., Hui, S.W., Zhao, Y.L.: US20026383138 (2002).
34. Mir LM, Belehradek M, Domenge C, et al. Electrochemotherapy, a new antitumor treatment: first clinical trial. C R Acad Sci III 1991; 313: 613-18.
35. Heller R, Jaroszeski MJ, Glass LF, et al. Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer 1996; 77: 964-71.
36. Byrne CM, Thompson JF. Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors. Expert Rev Anticancer Ther 2006; 6: 671-78.
37. Giardino R, Fini M, Bonazzi, V, et al. Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues. Biomed Pharmacother 2006; 60: 458-62.
38. Mir LM, Morsli N, Garbay JR, et al. Electrochemotherapy a new treatment of solid tumors. J Exp Clin Cancer Res 2003; 22: 145-8.
39. Mir, L.: US5468223 (1995).
40. Gilbert RA, Jaroszeski MJ, Heller R. Novel electrode designs for electrochemotherapy. Biochim Biophys Acta 1997; 1334: 9-14.
41. Yuzhakov, V.V., Sherman, F.F., Owens, G.D.,Gartstein, V.: US20016256533 (2001).
42. Hofmann, GA., Rabussay, D.P., Zhang; L.: US20077171264 (2007).
43. Mir LM, Glass LF, Sersa G, et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer 1998; 77: 2336-42.
44. Hofinann, G.A.: US5702359 (1997).
45. Bernard, R.M.: US5873849 (1999).
46. Gilbert, R., Jaroszeski, M., Heller, R.: US20016314316 (2001).
47. Prausnitz, M.R., Allen, M.G., Henry, S., McAllister,, D.V, Ackley, D.E., Jackson, T.: US20046743211 (2004).
48. Miller, DJ., Higuchi, W.I., Li, K., Flynn, G.L.: US20067137975 (2006).
49. Gehl J, Sorensen TH, Nielsen K, et al. in vivo Electroporation of skeletal muscle: threshold, efficacy and relation to electric field distribution. Biochim Biophys Acta 1999; 1428: 233-40.
50. Wong, T.W., Hui, S.W.,. Chen, C.H., Huang, C.C., Lin, C.D.: US20070016125 (2007).
51. Vanbever R, Fouchard D, Jadoul A, et al. in vivo Noninvasive evaluation of hairless rat skin after high-voltage pulse exposure. Skin Pharmacol Appl Skin Physiol 1998; 11: 23-34.
52. Burgess SE, Zhao YL, Seri A, Hui SW. Resealing of electroporation of porcine epidermis using phospholipids and poloxamers. Int J Pharm 2007; 336: 269-75.
53. Murthy SN, Sen A, Hui SW. Surfactant-enhanced transdermal delivery by electroporation. J Control Release 2004; 98: 307-15.
54. Johnson, M.E., Mitragotri, S.S., Blankschtein, D., Langer, R.S., Pishko, M., Kost, J.: US5947921 (1999).
55. Kost, J., Pliquett, U., Mitragotri, S.S., Langer, R.S., Weaver, J.C.: US20096041251 (2000).
56. Ashton P, Hadgraft J, Walters KA. Effects of surfactants in percutaneous absorption. Pharm Acta Helv 1986; 61: 228-35.
57. Williams AC, Barry BW. Penetration enhancers. Adv Drug Deliv Rev 2004; 56: 603-18.
58. Cevc G, Gebauer D. Hydration-driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophys J 2003; 84: 1010-24.
59. Walker, J.P:, Bernard, R.M.: US20006041252 (2000).
60. Singh J, Roberts MS. Transdermal delivery of drugs by iontophoresis: a review. Drug Des Deliv 1989; 4: 1-12.
61. Giammarusti, P.: US20046795727 (2O04).
62. Dev, N.B., Dev, S.B., Hofmann, G.A.: US20056865416 (2005).
63. Murthy SN, Zhao YL, Hui SW, Sen A. Electroporation and transcutaneous extraction (ETE) for pharmacokinetic studies of drugs. J Control Release 2005; 105: 132-41.