Heart spotting

Basic Research in Cardiology

Volumn 103, Issue 3, 2008, Pages 228-231

  el Azzouzi, Hamid ^a   De Windt, Leon J ^a,b  

^a HUBRECHT INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Calcineurin; Energy metabolism; Heart failure

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCINEURIN; CYCLOSPORIN A; FATTY ACID; LISINOPRIL; TACROLIMUS;

DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; EDITORIAL; ENERGY METABOLISM; FATTY ACID METABOLISM; FATTY ACID OXIDATION; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; METABOLOMICS; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION;

ANIMALS; CALCINEURIN; CARDIOMEGALY; ENERGY METABOLISM; HEART FAILURE; HUMANS; METABOLOMICS; MITOCHONDRIA, HEART; MYOCARDIUM; VENTRICULAR REMODELING;

EID: 42249091175     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-008-0698-z     Document Type: Editorial

References (18)

1. Bueno OF, van Rooij E, Molkentin JD, Doevendans PA, De Windt LJ (2002) Calcineurin and hypertrophic heart disease: Novel insights and remaining questions. Cardiovasc Res 53:806-821
2. Bueno OF, Wilkins BJ, Tymitz KM, Glascock BJ, Kimball TF, Lorenz JN, Molkentin JD (2002) Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci USA 99:4586-4591
3. Degens H, de Brouwer KF, Gilde AJ, Lindhout M, Willemsen PH, Janssen BJ, van der Vusse GJ, van Bilsen M (2006) Cardiac fatty acid metabolism is preserved in the compensated hypertrophic rat heart. Basic Res Cardiol 101:17-26
4. Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, Rockman HA (2002) Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105:85-92
5. Fischer P, Hilfiker-Kleiner D (2007) Survival pathways in hypertrophy and heart failure: The gp130-STAT axis. Basic Res Cardiol 102:393-411
6. Grammer JB, Bleiziffer S, Monticelli F, Lange R, Bauernschmitt R (2006) Calcineurin and matrix protein expression in cardiac hypertrophy: evidence for calcineurin B to control excessive hypertrophic signaling. Basic Res Cardiol 101:292-300
7. Huber D, Grimm J, Koch R, Krayenbuehl HP (1981) Determinants of ejection performance in aortic stenosis. Circulation 64:126-134
8. Janczewski AM, Zahid M, Lemster BH, Frye CS, Gibson G, Higuchi Y, Kranias EG, Feldman AM, McTiernan CF (2004) Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model. Cardiovasc Res 62:468-480
9. 2+ ATPase expression. Circulation 113:2724-2732
10. Krayenbuehl HP, Hess OM, Ritter M, Monrad ES, Hoppeler H (1988) Left ventricular systolic function in aortic stenosis. Eur Heart J 9(Suppl E):19-23
11. Maack C, O'Rourke B (2007) Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol 102:369-392
12. Molkentin JD (2004) Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovasc Res 63:467-475
13. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93:215-228
14. Munch G, Bolck B, Karczewski P, Schwinger RH (2002) Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium. J Mol Cell Cardiol 34:321-334
15. Perlini S, Muiesan ML, Cuspidi C, Sampieri L, Trimarco B, Aurigemma GP, Agabiti-Rosei E, Mancia G (2001) Midwall mechanics are improved after regression of hypertensive left ventricular hypertrophy and normalization of chamber geometry. Circulation 103:678-683
16. Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA (2003) Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am J Physiol Cell Physiol 284:C562-C570
17. Schott P, Asif AR, Graf C, Toischer K, Hasenfuss G, Kogler H (2008) Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity. A proteomic approach. Basic Res Cardiol
18. van Rooij E, Doevendans PA, Crijns HJ, Heeneman S, Lips DJ, van Bilsen M, Williams RS, Olson EN, Bassel-Duby R, Rothermel BA, De Windt LJ (2004) MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction. Circ Res 94:e18-e26