Cardiotrophin-1 enhances regeneration of cirrhotic liver remnant after hepatectomy through promotion of angiogenesis and cell proliferation

Liver International

Volumn 28, Issue 5, 2008, Pages 622-631

  Yang, Zhen Fan ^a   Lau, Chi Keung ^a   Ngai, Patricia ^a   Lam, Shuk Pik ^a   Ho, David W ^a   Poon, Ronnie Tung Ping ^a   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Angiogenesis; Cardiotrophin 1; Cirrhosis; Hepatectomy

Indexed keywords

BROXURIDINE; CARDIOTROPHIN 1; CYCLIN D1; GLYCOPROTEIN GP 130; KI 67 ANTIGEN; PROTEIN P42; PROTEIN P44; SYNAPTOTAGMIN I; VASCULOTROPIN; VATALANIB; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; LIVER CELL; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER REGENERATION; LIVER RESECTION; LIVER WEIGHT; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SHORT COURSE THERAPY; SINGLE DRUG DOSE; SURVIVAL RATE; UPREGULATION;

ANIMALS; CARBON TETRACHLORIDE; CELL PROLIFERATION; CYTOKINES; HEPATECTOMY; HEPATOCYTES; LIVER CIRRHOSIS; LIVER REGENERATION; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, INBRED BUF; TRANSCRIPTION FACTOR RELA; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 42149194261     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01687.x     Document Type: Article

References (37)

1. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907-17.
2. McMahon BJ. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005; 25 (Suppl. 1): 3-8.
3. El-Serag HB. Hepatocellular carcinoma: Recent trend in the United States. Gastroenterology 2004; 127: S27-34.
4. Bruix J, Hessheimer AJ, Forner A, Boix L, Vilana R, Llovet JM. New aspects of diagnosis and therapy of hepatocellular carcinoma. Oncogene 2006; 25: 3848-56.
5. Arii S, Yamaoka Y, Futagawa S, et al. Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology 2000; 32: 1224-9.
6. Teh SH, Christein J, Donohue J, et al. Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: Model of End-Stage Liver Disease (MELD) score predicts perioperative mortality. J Gastrointest Surg 2005; 9: 1207-15.
7. Otsuka Y, Duffy JP, Saab S, et al. Postresection hepatic failure: successful treatment with liver transplantation. Liver Transpl 2007; 13: 672-9.
8. Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006; 43: S45-53.
9. Ijichi H, Taketomi A, Yoshizumi T, et al. Hyperbaric oxygen induces vascular endothelial growth factor and reduces liver injury in regenerating rat liver after partial hepatectomy. J Hepatol 2006; 45: 28-34.
10. Alvaro D, Mancino MG, Glaser S, et al. Proliferating cholangiocytes: A neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132: 415-31.
11. Kallis Y, Alison MR, Forbes SJ. Bone marrow stem cells and liver disease. Gut 2006; 56: 716-24.
12. Heinrich S, Jochum W, Graf R, Clavien PA. Portal vein ligation and partial hepatectomy differentially influence growth of intrahepatic metastasis and liver regeneration in mice. J Hepatol 2006; 45: 35-42.
13. Vetelainen R, Dinant S, van Vliet A, van Gulik TM. Portal vein ligation is as effective as sequential portal vein and hepatic artery ligation in inducing contralateral liver hypertrophy in a rat model. J Vasc Interv Radiol 2006; 17: 1181-8.
14. Yang ZF, Poon RT, To J, Ho DW, Fan ST. The potential role of hypoxia inducible factor 1alpha in tumor progression after hypoxia and chemotherapy in hepatocellular carcinoma. Cancer Res 2004; 64: 5496-503.
15. Khai NC, Takahashi T, Ushikoshi H, et al. In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: A comparative study to HGF. J Hepatol 2006; 44: 1046-54.
16. Jin X, Zimmers TA, Perez EA, Pierce RH, Zhang Z, Koniaris LG. Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair. Hepatology 2006; 43: 474-84.
17. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem 1997; 272: 5783-91.
18. Freed DH, Cunnington RH, Dangerfield AL, Sutton JS, Dixon IM. Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovasc Res 2005; 65: 782-92.
19. Toh R, Kawashima S, Kawai M, et al. Transplantation of cardiotrophin-1-expressing myoblasts to the left ventricular wall alleviates the transition from compensatory hypertrophy to congestive heart failure in Dahl salt-sensitive hypertensive rats. J Am Coll Cardiol 2004; 43: 2337-47.
20. Nomura N, Asano M, Saito T, et al. Cardiotrophin-1 is a prophylactic against the development of chronic hypoxic pulmonary hypertension in rats. Ann Thorac Surg 2003; 76: 237-43.
21. Lesbordes JC, Cifuentes-Diaz C, Miroglio A, et al. Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy. Hum Mol Genet 2003; 12: 1233-9.
22. Bustos M, Beraza N, Lasarte JJ, et al. Protection against liver damage by cardiotrophin-1: A hepatocyte survival factor up-regulated in the regenerating liver in rats. Gastroenterology 2003; 125: 192-201.
23. Ho DW, Yang ZF, Lau CK, et al. Therapeutic potential of cardiotrophin 1 in fulminant hepatic failure: Dual roles in antiapoptosis and cell repair. Arch Surg 2006; 141: 1077-84.
24. Yang ZF, Poon RT, Liu Y, et al. High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of HCC: Dual effects on cancer cell and angiogenesis. Mol Cancer Ther 2006; 5: 2261-70.
25. Tsui TY, Lau CK, Ma J, et al. rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: A new approach to attenuate liver fibrosis in rats. Hepatology 2005; 42: 335-42.
26. Yang ZF, Ho DW, Chu AC, Wang YQ, Fan ST. Linking inflammation to acute rejection in small-for-size liver allografts: The potential role of early macrophage activation. Am J Transpl 2004; 4: 196-209.
27. Iniguez M, Berasain C, Martinez-Anso E, et al. Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning. J Exp Med 2006; 203: 2809-15.
28. Hamanaka I, Saito Y, Yasukawa H, et al. Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo. Circ Res 2001; 88: 727-32.
29. Hamanaka I, Saito Y, Nishikimi T, et al. Effects of cardiotrophin-1 on hemodynamics and endocrine function of the heart. Am J Physiol Heart Circ Physiol 2000; 279: H388-96.
30. Rind HB, Butowt R, von Bartheld CS. Synaptic targeting of retrogradely transported trophic factors in motoneurons: Comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin. J Neurosci 2005; 25: 539-49.
31. Vetelainen R, van Vliet AK, van Gulik TM. Severe steatosis increases hepatocellular injury and impairs liver regeneration in a rat model of partial hepatectomy. Ann Surg 2007; 245: 44-50.
32. Safadi R, Ohta M, Alvarez CE, et al. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 2004; 127: 870-82.
33. Medina J, Arroyo AG, Sanchez-Madrid F, Moreno-Otero R. Angiogenesis in chronic inflammatory liver disease. Hepatology 2004; 39: 1185-95.
34. Taniguchi E, Kin M, Torimura T, et al. Endothelial progenitor cell transplantation improves the survival following liver injury in mice. Gastroenterology 2006; 130: 521-31.
35. Craig R, Wagner M, McCardle T, Craig AG, Glembotski CC. The cytoprotective effects of the glycoprotein 130 receptor-coupled cytokine, cardiotrophin-1, require activation of NF-kappa B. J Biol Chem 2001; 276: 37621-9.
36. Middleton G, Hamanoue M, Enokido Y, et al. Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol 2000; 148: 325-32.
37. Beraza N, Marques JM, Martinez-Anso E, Iniguez M, Prieto J, Bustos M. Interplay among cardiotrophin-1, prostaglandins, and vascular endothelial growth factor in rat liver regeneration. Hepatology 2005; 41: 460-9.