The mold conundrum in chronic rhinosinusitis: Where do we stand today?

Current Allergy and Asthma Reports

Volumn 8, Issue 2, 2008, Pages 93-101

  Ebbens, Fenna A ^a   Fokkens, Wytske J ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CORTICOSTEROID; IMMUNOGLOBULIN G; ITRACONAZOLE; KETOCONAZOLE; PLACEBO; TERBINAFINE;

ALLERGY; ALTERNARIA; ASPERGILLUS; AUREOBASIDIUM; CANDIDA; CELL ACTIVATION; CELL DAMAGE; CELLULAR IMMUNITY; CHRONIC DISEASE; CLADOSPORIUM; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONUNDRUM; DRUG MEGADOSE; DRUG SENSITIVITY; EOSINOPHILIA; FUNGAL CONTAMINATION; FUNGUS CULTURE; FUNGUS IDENTIFICATION; HUMAN; HUMORAL IMMUNITY; HYPERSENSITIVITY; IMMUNOTHERAPY; INNATE IMMUNITY; LONG TERM CARE; MOULD; MYCOSIS; NOSE MUCOSA; PATHOGENESIS; PENICILLIUM; PREVALENCE; REVIEW; RHINOSINUSITIS; SKIN TEST; UNSPECIFIED SIDE EFFECT;

ANTIBODY FORMATION; ANTIFUNGAL AGENTS; CARRIER STATE; DISEASE SUSCEPTIBILITY; FUNGI; HUMANS; MYCOSES; NASAL MUCOSA; RHINITIS; SINUSITIS;

EID: 42149186478     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-008-0018-6     Document Type: Review

References (54)

1. Fokkens W, Lund V, Mullol J, et al.: European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 2007, 45:1-139.
2. DeShazo RD, Chapin K, Swain RE: Fungal sinusitis. N Engl J Med 1997, 337:254-259.
3. Ponikau JU, Sherris DA, Kern EB, et al.: The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 1999, 74:877-884.
4. Katzenstein AL, Sale SR, Greenberger PA: Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol 1983, 72:89-93.
5. Robson JM, Hogan PG, Benn RA, Gatenby PA: Allergic fungal sinusitis presenting as a paranasal sinus tumour. Aust N Z J Med 1989, 19:351-353.
6. Bent JP 3rd, Kuhn FA: Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg 1994, 111:580-588.
7. DeShazo RD, Swain RE: Diagnostic criteria for allergic fungal sinusitis. J Allergy Clin Immunol 1995, 96:24-35.
8. Ferguson BJ: Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope 2000, 110(5 Pt 1):799-813.
9. Ebbens FA, Georgalas C, Rinia AB, et al.: The fungal debate: where do we stand today? Rhinology 2007, 45:178-189.
10. Catten MD, Murr AH, Goldstein JA, et al.: Detection of fungi in the nasal mucosa using polymerase chain reaction. Laryngoscope 2001, 111:399-403.
11. Rao AK, Mathers PH, Ramadan HH: Detection of fungi in the sinus mucosa using polymerase chain reaction. Otolaryngol Head Neck Surg 2006, 134:581-585.
12. Polzehl D, Weschta M, Podbielski A, et al.: Fungus culture and PCR in nasal lavage samples of patients with chronic rhinosinusitis. J Med Microbiol 2005, 54(Pt 1):31-37.
13. Scheuller MC, Murr AH, Goldberg AN, et al.: Quantitative analysis of fungal DNA in chronic rhinosinusitis. Laryngoscope 2004, 114:467-471.
14. Kim ST, Choi JH, Jeon HG, et al.: Comparison between polymerase chain reaction and fungal culture for the detection of fungi in patients with chronic sinusitis and normal controls. Acta Otolaryngol 2005, 125:72-75.
15. Murr AH, Goldberg AN, Vesper S: Fungal speciation using quantitative polymerase chain reaction (QPCR) in patients with and without chronic rhinosinusitis. Laryngoscope 2006, 116:1342-1348.
16. Weschta M, Rimek D, Formanek M, et al.: Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 2004, 113:1122-1128.
17. Taylor MJ, Ponikau JU, Sherris DA, et al.: Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein. Otolaryngol Head Neck Surg 2002, 127:377-383.
18. Kennedy DW, Kuhn FA, Hamilos DL, et al.: Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 2005, 115:1793-1799.
19. Buzina W, Braun H, Freudenschuss K, et al.: Fungal biodiversity - as found in nasal mucus. Med Mycol 2003, 41:149-161.
20. Ponikau JU, Sherris DA, Weaver A, Kita H: Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol 2005, 115:125-131.
21. Jiang RS, Su MC, Lin JF: Nasal mycology of chronic rhinosinusitis. Am J Rhinol 2005, 19:131-133.
22. Tosun F, Hidir Y, Sarach MA, et al.: Intranasal fungi and chronic rhinosinusitis: what is the relationship? Ann Otol Rhinol Laryngol 2007, 116:425-429.
23. Ragab A, Clement P, Vincken W, et al.: Fungal cultures of different parts of the upper and lower airways in chronic rhinosinusitis. Rhinology 2006, 44:19-25.
24. Lackner A, Stammberger H, Buzina W, et al.: Fungi: a normal content of human nasal mucus. Am J Rhinol 2005, 19:125-129.
25. Ferguson BJ, Barnes L, Bernstein JM, et al.: Geographic variation in allergic fungal rhinosinusitis. Otolaryngol Clin North Am 2000, 33:441-449.
26. Faure O, Fricker-Hidalgo H, Lebeau B, et al.: Eight-year surveillance of environmental fungal contamination in hospital operating rooms and haematological units. J Hosp Infect 2002, 50:155-160.
27. Mitakakis TZ, Barnes C, Tovey ER: Spore germination increases allergen release from Alternaria. J Allergy Clin Immunol 2001, 107:388-390.
28. Ponikau JU, Sherris DA, Kita H, Kern EB: Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol 2002, 110:862-866.
29. Ebbens FA, Scadding GK, Badia L, et al.: Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 2006, 118:1149-1156.
30. Pant H, Kette FE, Smith WB, et al.: Fungal-specific humoral response in eosinophilic mucus chronic rhinosinusitis. Laryngoscope 2005, 115:601-606.
31. Shin SH, Ponikau JU, Sherris DA, et al.: Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol 2004, 114:1369-1375.
32. Beenhouwer DO, Yoo EM, Lai CW, et al.: Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection. Infect Immun 2007, 75:1424-1435.
33. Ponikau JU, Sherris DA, Kephart GM, et al.: Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma? J Allergy Clin Immunol 2003, 112:877-882.
34. Ponikau JU, Sherris DA, Kephart GM, et al.: Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis. J Allergy Clin Immunol 2005, 116:362-369.
35. Wei JL, Kita H, Sherris DA, et al.: The chemotactic behavior of eosinophils in patients with chronic rhinosinusitis. Laryngoscope 2003, 113:303-306.
36. Griffin E, Hakansson L, Formgren H, et al.: Increased chemokinetic and chemotactic responses of eosinophils in asthmatic patients. Allergy 1991, 46:255-265.
37. Koenderman L, van der Bruggen T, Schweizer RC, et al.: Eosinophil priming by cytokines: from cellular signal to in vivo modulation. Eur Respir J Suppl 1996, 22:119s-125s.
38. Haselden BM, Syrigou E, Jones M, et al.: Proliferation and release of IL-5 and IFN-gamma by peripheral blood mononuclear cells from cat-allergic asthmatics and rhinitics, non-cat-allergic asthmatics, and normal controls to peptides derived from Fel d 1 chain 1. J Allergy Clin Immunol 2001, 108:349-356.
39. Douglas R, Bruhn M, Tan LW, et al.: Response of peripheral blood lymphocytes to fungal extracts and staphylococcal superantigen B in chronic rhinosinusitis. Laryngoscope 2007, 117:411-414.
40. Inoue Y, Matsuwaki Y, Shin SH, et al.: Nonpathogenic, nvironmental fungi induce activation and degranulation of human eosinophils. J Immunol 2005, 175:5439-5447.
41. Frigas E, Motojima S, Gleich GJ: The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. Eur Respir J Suppl 1991, 13:123s-135s.
42. Kauffman HF, Tomee JF, van de Riet MA, et al.: Protease-dependent activation of epithetial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol 2000, 105:1185-1193.
43. Reed CE, Kita H: The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 2004, 114:997-1008.
44. Ooi EH, Wormald PJ, Carney AS, et al.: Fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model. Am J Rhinol 2007, 21:367-372.
45. Ooi EH, Wormald PJ, Carney AS, et al.: Surfactant protein d expression in chronic rhinosinusitis patients and immune responses in vitro to Aspergillus and alternaria in a nasal explant model. Laryngoscope 2007, 117:51-57.
46. Bent JP 3rd, Kuhn FA: Antifungal activity against allergic fungal sinusitis organisms. Laryngoscope 1996, 106:1331-1334.
47. Kfoury AG, Smith JC, Farhoud HH, et al.: Adjuvant intrapleural amphotericin B therapy for pulmonary mucormycosis in a cardiac allograft recipient. Clin Transplant 1997, 11:608-612.
48. Leu HS, Huang CT: Clearance of funguria with short-course antifungal regimens: a prospective, randomized, controlled study. Clin Infect Dis 1995, 20:1152-1157.
49. Shirazi MA, Stankiewicz JA, Kammeyer P: Activity of nasal amphotericin B irrigation against fungal organisms in vitro. Am J Rhinol 2007, 21:145-148.
50. Bhattacharyya T, Piccirillo J, Wippold FJ: Relationship between patient-based descriptions of sinusitis and paranasal sinus computed tomographic findings. Arch Otolaryngol Head Neck Surg 1997, 123:1189-1192.
51. Ricchetti A, Landis BN, Maffioli A, et al.: Effect of antifungal nasal lavage with amphotericin B on nasal polyposis. J Laryngol Otol 2002, 116:261-263.
52. Rains BM 3rd, Mineck CW: Treatment of allergic fungal sinusitis with high-dose itraconazole. Am J Rhinol 2003, 17:1-8.
53. Mabry RL, Marple BF, Folker RJ, Mabry CS: Immunotherapy for allergic fungal sinusitis: three years' experience. Otolaryngol Head Neck Surg 1998, 119:648-651.
54. Mabry RL, Marple BF, Mabry CS: Outcomes after discontinuing immunotherapy for allergic fungal sinusitis. Otolaryngol Head Neck Surg 2000, 122:104-106.