Synthesis of 1-substituted 3-pyridinylmethylidenylindolin-2-ones and 1-substituted 3-quinolinylmethylidenylindolin-2-ones as the enhancers of ATRA-induced differentiation in HL-60 cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4222-4232

  Hung, Chi Ying ^a   Hsu, Mei Hua ^b   Huang, Li Jiau ^b   Hwang, Chrong Shiong ^a   Lee, On ^a   Wu, Chen Yi ^a   Chen, Chih Hung ^a   Kuo, Sheng Chu ^b  

^a INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

ATRA; Differentiation; HL 60; Indolinone; Leukemia; Pyridinylidenylindolinone; Quinolinylidenylindolinone

Indexed keywords

1 (1 NAPHTHYLMETHYL) 3 (4 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (1 PHENYLETHYL) 3 (2 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (1 PHENYLETHYL) 3 (2 QUINOLINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (1 PHENYLETHYL) 3 (3 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (1 PHENYLETHYL) 3 (3 QUINOLINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (1 PHENYLETHYL) 3 (4 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (1 PHENYLETHYL) 3 (4 QUINOLINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 (2 NAPHTHYLMETHYL) 3 (4 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 (2 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 (2 QUINOLINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 (3 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 (3 QUINOLINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 (4 PYRIDINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 (4 QUINOLINYLMETHYLIDENYL)INDOLIN 2 ONE; 1 BENZYL 3 [4 (N OXY PYRIDINYLMETHYLIDENYL)]INDOLIN 2 ONE; INDOLE DERIVATIVE; RETINOIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOMERISM; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; HL-60 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MOLECULAR STRUCTURE; PYRIMIDINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRETINOIN;

EID: 42149182035     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.093     Document Type: Article

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