Compositional differences among undamaged, strained, and failed regions of bone using Raman spectroscopy

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6853, Issue , 2008, Pages

  Dooley, Kathryn A ^a   McCormack, Jordan ^b   Fyhrie, David P ^b   Morris, Michael D ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone; Bone mechanics; Double notch; Fracture mechanics; Imaging; Mechanical testing; Raman spectroscopy

Indexed keywords

BONE FRACTURES; COMPOSITIONAL CHANGES; FOUR-POINT BENDING; FRACTURE RISKS; OPTICAL SPECTROSCOPIES; SPECTRA (CO); WAVE-NUMBERS;

ARCHITECTURAL ACOUSTICS; FRACTURE; FRACTURE FIXATION; MICROFLUIDICS; PETROLEUM DEPOSITS; PETROLEUM RESERVOIRS; RAMAN SCATTERING; RAMAN SPECTROSCOPY; REAL TIME SYSTEMS; RISK ASSESSMENT; SPECTRUM ANALYSIS; TISSUE;

BONE;

EID: 42149177275     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.763282     Document Type: Conference Paper

References (15)

1. Ritchie, R. O., Kinney, J. H., Kruzic, J. J., and Nalla, R. K., "A fracture mechanics and mechanistic approach to the failure of cortical bone," Fatigue Fract. Eng. Mater. Struct. 28, 345-371 (2005).
2. Nalla, R. K., Kinney, J. H., and Ritchie, R. O., "Mechanistic fracture criteria for the failure of human cortical bone," Nature Mater. 2, 164-168 (2003).
3. Vashishth, D., Behiri, J. C., and Bonfield, W., "Crack growth resistance in cortical bone: Concept of microcrack toughening," J. Biomech. 30, 763-769 (1997).
4. Yener, T. L. N., Yeni, N., "Calculation of porosity and osteonal cement line effects on the effective fracture toughness of cortical bone in longitudinal crack growth," J. Biomed. Mater. Res. 51, 504-509 (2000).
5. Parsamian, G. P., and Norman, T. L., "Diffuse damage accumulation in the fracture process zone of human cortical bone specimens and its influence on fracture toughness," J. Mater. Sci. Mater. Med. 12, 779-783 (2001).
6. Nalla, R. K., Stolken, J. S., Kinney, J. H., and Ritchie, R. O., "Fracture in human cortical bone: local fracture criteria and toughening mechanisms," J. Biomech. 38, 1517-1525 (2005).
7. Schulmerich, M. V., Dooley, K. A., Morris, M. D., Vanasse, T. M., and Goldstein, S. A., "Transcutaneous fiber optic Raman spectroscopy of bone using annular illumination and a circular array of collection fibers," J. Biomed. Optics 11, 060502 (2006).
8. Schulmerich, M. V., Dooley, K. A., Vanasse, T. M., Goldstein, S. A., and Morris, M. D., "Subsurface and Transcutaneous Raman Spectroscopy and Mapping Using Concentric Illumination Rings and Collection with a Circular Fiber-Optic Array," Appl. Spectrosc. 61, 671-678 (2007).
9. Lieber, C. A., and Mahadevan-Jansen, A., "Automated Method for Subtraction of Fluorescence from Biological Raman Spectra," Appl. Spectrosc. 57, 1363-1367 (2003).
10. Gadaleta, S. J., Paschalis, E. P., Betts, F., Mendelsohn, R., and Boskey, A. L., "Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: New correlations between X-ray diffraction and infared data," Calcif. Tissue Int. 58, 9-16 (1996).
11. Sauer, G. R., Zunic, W. B., Durig, J. R., and Wuthier, R. E., "Fourier Transform Raman Spectroscopy of Synthetic and Biological Calcium Phosphates," Calcif. Tissue Int. 54, 414-420 (1994).
12. Pezzotti, G. and Sakakura, S., "Study of the toughening mechanisms in bone and biomimetic hydroxyapatite materials using Raman microprobe spectroscopy," J. Biomed. Mater. Res. 65A, 229-236 (2003).
13. Pezzotti, G., "Raman piezo-spectroscopic analysis of natural and synthetic biomaterials," Anal. Bioanal. Chem. 381, 577-590 (2005).
14. Morris, M. D., Tarnowski, C. P., Dreier, J. L., and Ignelzi, M. A., "Raman microscopy of denovo woven bone tissue," Proc. SPIE 4254, 90-96 (2001).
15. McCreadie, B. R., Morris, M. D., Chen, T.-c., Sudhaker Rao, D., Finney, W. F., Widjaja, E., and Goldstein, S.A., "Bone tissue compositional differences in women with and without osteoporotic fracture," Bone 39, 1190-1195 (2006).