Spontaneous leiomyosarcoma arising from the ethmoid turbinate of a rat

Toxicologic Pathology

Volumn 36, Issue 2, 2008, Pages 247-249

  Kasahara, Kenichiro ^a,b   Yamakawa, Seiki ^a   Nagatani, Mariko ^a   Tsurukame, Maiko ^a   Tamura, Kazutoshi ^a  

^a BoZo Research Center Inc   (Japan)

^b Biology and Zoology Research Center Inc   (Japan)

Author keywords

Leiomyosarcoma; Nasal cavity; Rat

Indexed keywords

SMOOTH MUSCLE ACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ETHMOID SINUS; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE; TUMOR CELL; TUMOR LOCALIZATION; TURBINATE;

ACTINS; ANIMALS; ETHMOID BONE; FATAL OUTCOME; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MALE; NASAL CAVITY; RATS; RATS, INBRED F344; SKULL NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; TURBINATES;

RATTUS;

EID: 42149173170     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623307312692     Document Type: Article

References (13)

1. Brown, H.R. (1990). Neoplastic and potentially preneoplastic changes in the upper respiratory tract of rats and mice. Environ Health Perspect 85, 291-304.
2. Brown, H.R., Monticello, T.M., Maronpot, R.R., Randall, H.W., Hotchkiss, J.R., and Morgan, K.T. (1991). Proliferative and neoplastic lesions in the rodent nasal cavity. Toxicol Pathol 19, 358-72.
3. Carcinogenesis bioassay of 1,2-Dibromoethane (CAS N0.106-93-4) in F344 rats and B6C3F1 mice (Inhalation study). (1982). Natl Toxicol Program Tech Rep Ser 210: 1-163.
4. de Saint Aubain Somerhausen, N., and Fletcher, C.D. (1999). Leiomyosarcoma of soft tissue in children: clinicopathologic analysis of 20 cases. Am J Surg Pathol 23, 755-63.
5. Fu, Y.S., and Perzin, K.H. (1975). Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. IV. Smooth muscle tumors (leiomyoma, leiomyosarcoma). Cancer 35, 1300-8.
6. Hemmi, A., Komiyama, A., Ohno, S., Fujii, Y., Katoh, R., Yokoyama, A., and Kawaoi, A. (1998). Poorly differentiated desmin-negative and vimentin-positive leiomyosarcoma of the stomach examined by the immunohistochemical and quick-freezing and deep-etching methods. Virchows Arch 432, 377-83.
7. Joseph, K.H., James, R.H., and Richard, W.M. (1998). Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a national toxicology program update. Toxicol Pathol 26, 428-41.
8. Josephson, R.L., Blair, R.L., and Bedard, Y.C. (1985). Leiomyosarcoma of the nose and paranasal sinuses. Otolaryngol Head Neck Surg 93, 270-4.
9. Lippert, B.M., Godbersen, G.S., Luttges, J., and Werner, J.A. (1996). Leiomyosarcoma of the nasal cavity. Case report and literature review. ORL J Otorhinolaryngol Relat Spec 58, 115-20.
10. NTP Toxicology and carcinogenesis studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS N0.87-62-7) in Charles River CD rats (Feed studies). (1990). Natl Toxicol Program Tech Rep Ser 278, 1-138.
11. Renne, R.A., Giddens, W.E., Boorman, G.A., Kovatch, R., Haseman, J.E., and Clarke, W.J. (1986). Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H) F1 mice inhaling propylene oxide for up to two years. J Natl Cancer Inst 77, 573-82.
12. Wilson, D.W., and Dungworth, D.L. (2002). Tumors of the respiratory tract. In Tumors in Domestic Animals (D. J. Meuten, ed., pp. 365-99). Blackwell, Ames, Iowa.
13. Yamamoto, T., Minami, R., Ohbayashi, C., and Inaba, M. (2003). Epithelioid leiomyosarcoma of the external deep soft tissue. Arch Pathol Lab Med 127, 402-4.