Single nucleotide polymorphism microarray analysis of karyotypically normal acute myeloid leukemia reveals frequent copy number neutral loss of heterozygosity

Haematologica

Volumn 93, Issue 4, 2008, Pages 631-632

  Tyybäkinoja, Anne ^a   Elonen, Erkki ^b   Vauhkonen, Hanna ^a   Saarela, Janna ^c   Knuutila, Sakari ^a,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Acute myeloid leukemia; LOH; Microarray; Normal karyotype; SNP

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; CANCER INHIBITION; DNA EXTRACTION; EPIGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FREQUENCY; GENE MUTATION; HETEROZYGOSITY; HUMAN; KARYOTYPE; LETTER; MICROARRAY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ACUTE DISEASE; ADULT; AGED; FEMALE; GENE DOSAGE; HUMANS; KARYOTYPING; LEUKEMIA, MONOCYTIC, ACUTE; LEUKEMIA, MYELOID, ACUTE; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; UNIPARENTAL DISOMY;

EID: 42149136793     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.12232     Document Type: Letter

References (9)

1. Mrozek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood 2007;109:431-48.
2. Dalley CD, Neat MJ, Foot NJ, Burridge M, Byrne L, Amess JA, et al. Comparative genomic hybridization and multiplex-fluorescence in situ hybridization: an appraisal in elderly patients with acute myelogenous leukemia. Hematol J 2002;3:290-8.
3. Suela J, Alvarez S, Cifuentes F, Largo C, Ferreira BI, Blesa D, et al. DNA profiling analysis of 100 consecutive de novo acute myeloid leukemia cases reveals patterns of genomic instability that affect all cytogenetic risk groups. Leukemia 2007;21:1224-31.
4. Tyybakinoja A, Elonen E, Piippo K, Porkka K, Knuutila S. Oligonucleotide array-CGH reveals cryptic gene copy number alterations in karyotypically normal acute myeloid leukemia. Leukemia 2007;21:571-4.
5. Gorletta TA, Gasparini P, D'Elios MM, Trubia M, Pelicci PG, Di Fiore PP. Frequent loss of heterozygosity without loss of genetic material in acute myeloid leukemia with a normal karyotype. Genes Chromosomes Cancer 2005;44:334-7.
6. Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, et al. A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res 2005;65:6071-9.
7. Griffiths M, Mason J, Rindl M, Akiki S, McMullan D, Stinton V, et al. Acquired isodisomy for chromosome 13 is common in AML, and associated with FLT3-itd mutations. Leukemia 2005;19:2355-8.
8. Whitman SP, Archer KJ, Feng L, Baldus C, Becknell B, Carlson BD, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res 2001;61:7233-9.
9. Fitzgibbon J, Smith LL, Raghavan M, Smith ML, Debernardi S, Skoulakis S, et al. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias. Cancer Res 2005;65:9152-4.