Metal active site elasticity linked to activation of homocysteine in methionine synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 9, 2008, Pages 3286-3291

  Koutmos, Markos ^a   Pejchal, Robert ^a,c   Bomer, Theresa M ^a   Matthews, Rowena G ^a,b   Smith, Janet L ^a,b   Ludwig, Martha L ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cobalamin dependent methionine synthase; Cobalamin independent methionine synthase; Methyl transferases; Zinc enzymes; Zinc inversion

Indexed keywords

HOMOCYSTEINE; METHIONINE SYNTHASE; ZINC; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; CYANOCOBALAMIN; METAL; METHYLCOBALAMIN - HOMOCYSTEINE METHYLTRANSFERASE; METHYLCOBALAMIN HOMOCYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMOTOGA MARITIMA; BINDING SITE; CATALYSIS; CHEMISTRY; ELASTICITY; ENZYMOLOGY; METABOLISM; METHYLATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELASTICITY; HOMOCYSTEINE; METALS; METHYLATION; METHYLTRANSFERASES; PROTEIN CONFORMATION; THERMOTOGA MARITIMA; VITAMIN B 12; ZINC;

EID: 42149131486     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709960105     Document Type: Article

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