Antiulcer effect of mammalian lignan precursors from flaxseed

Pharmaceutical Biology

Volumn 46, Issue 5, 2008, Pages 329-332

  Joshi, Sonali ^a   Mandawgade, Sagar ^a   Mehta, Vinam ^a   Sathaye, Sadhana ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Antiulcer activity; Flaxseed lignans; NSAID; Reduced glutathione; Ulcer index

Indexed keywords

ANTIULCER AGENT; BETA CAROTENE; DICLOFENAC; GLUTATHIONE; LIGNAN DERIVATIVE; LINUM USITATISSIMUM EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; LINSEED; MALE; MEDICINAL PLANT; NONHUMAN; RAT; STATISTICAL SIGNIFICANCE; STOMACH ULCER; ULCEROGENESIS; WISTAR RAT;

LINACEAE; LINUM USITATISSIMUM; MAMMALIA; RATTUS NORVEGICUS;

EID: 42149124944     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200801887732     Document Type: Article

References (18)

1. Axelson M, Sjovall J, Gustafsson BE, Setchell KD (1982): Origin of lignans in mammals and identification of a precursor from plants. Nature 298: 659-660.
2. Bolton S, Bon C (2004): Analysis of variance. In: Swarbrick J, ed., Pharmaceutical Statistics: Practical and Clinical Applications, 4th ed., Vol. 135, Marcel Dekker Inc., New York, pp. 215-264.
3. Clark WF, Parbtani A, Huff MW, Spanner H, De Salis H, Chin-Yee I, Philbrick DJ, Holub BJ (1995): Flaxseed - a potential treatment for lupus nephritis. Kidney Int 48: 475-480.
4. Cunnane SC, Ganguli S, Menard C, Leide AC, Hamadeh MJ, Chen ZY, Wolever TM, Jenkins DJ (1993): High α-linolenic acid flaxseed (Linum usitatissimum): Some nutritional properties in humans. Br J Nutr 69: 443-453.
5. Cunnane SC, Hamadeh MJ, Leide AC, Thompson LU, Wolever TM, Jenkins DJ (1995): Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 61: 62-68.
6. Lu, H, Liu GT (1991): Effect of dibenzo[a, c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. Chem-Biol Interactions 78: 77-84.
7. Ingram AJ, Parbtani A, Clark WF, Spanner E, Huff MW, Philbrick DJ, Holub BJ (1995): Effects of flaxseed and flax oil in a rat renal ablation model. Am J Kidney Dis 25: 320-329.
8. Judd A (1995): Flax-some historical considerations. In: Cunnane SC, Thompson LU, eds. Flaxseed and Human Nutrition, AOCS Press, Champaign, IL, pp. 1-10.
9. Levander OA, Ager AL (1995): Anti-malarial effects of flaxseed and flaxseed oil. In: Cunnane SC, Thompson LU, eds. Flaxseed and Human Nutrition. AOCS Press, Champaign, IL, pp. 237-243.
10. Majumdar B, Chaudhari SGR, Ray A, Bandyopadhyay SK (2003): Effect of ethanol extract of Piper betle Linn. leaf on healing of NSAID-induced experimental ulcer- a novel role of free radical scavenging action. Ind J Exp Biol 41: 311-315.
11. Obermeyer W (1993): Meeting of the Federation of American Societies for Experimental Biology on Experimental Biology March/April, A863.
12. Owens CWI, Belcher RV (1965): A colorimetric micro-method for the determination of glutathione. Biochem J 94: 705-711.
13. Serraino M, Thompson LU (1991): The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 60: 135-142.
14. Tarwadi K, Agte V (2003): Potential of commonly consumed green leafy vegetables for their anti-oxidant capacity and its linkage with the micronutrient profile. Int J Food Sci Nutr 54: 417-425.
15. Thompson LU (1994): Anti-oxidants and hormone-mediated health benefits of whole grains. Crit Rev Food Sci Nutr 34: 473-497.
16. Thompson LU, Rickard SE, Orcheson LJ, Seidl MM (1996): Flaxseed and its lignan and oil components reducemammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 17: 1373-1376.
17. Thompson LU, Robb P, Serraino M, Cheung F (1991):Mammalian lignan production from various foods. Nutr Cancer 16: 43-52.
18. Vogel HG, Vogel H (1997): Drug Discovery and Evaluation. Springer-Verlag, Berlin, p. 486.