Efficacy of 2-PAM, MMB-4, TMB-4, toxogonin and HI-6 in reactivation of acetylcholinesterase inhibited by warfare organophosphorus compounds of the G series

Current Topics in Pharmacology

Volumn 10, Issue 2, 2006, Pages 71-76

  Hoskovcová, Monika ^a   Halámek, Emil ^a   Kobliha, Zbyněk ^a   Tušarová, Ivana ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b Oritest Ltd   (Czech Republic)

Author keywords

2 PAM; Acetylcholinesterase; Biochemical cholinesterase reaction; Cyclosarin; HI 6; Inhibition; MMB 4; Reactivation; Sarin; Soman; Tabun; TMB 4; Toxogonin

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINESTERASE; CYCLOSARIN; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; PRALIDOXIME; SARIN; SOMAN; TABUN; TRIMEDOXIME;

ARTICLE; CHEMICAL WARFARE; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME IMMOBILIZATION; ENZYME INHIBITION;

EID: 42149122652     PISSN: 09724559     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Chambers, J. E., and Oppenheimer, S. F. 2004, Toxicol. Sci., 2, 185-187.
2. Somani, S. M., 1992, Chemical warfare Agents, UK: Academic Press.
3. Massoulie, J., Sussman, J., Bon, S., and Silman, I. 1993, Prog. Brain. Res., 98, 139-146.
4. Poziomek, E. J., Hackley, B. E. Jr., and Steinberg, G. M. 1958, J. Org. Chem., 23, 714-718.
5. Hobinger, F., and Sadler, P. W. 1959, B. J. Pharm., 14, 192-201.
6. Rogne, O. 1967, Biochem. Pharm., 2, 1853-1857.
7. Fleisher, J. H., Harris, L. W., and Murtha, E. F. 1967, J. Pharmacol. Exp. Ther., 156, 345-351.
8. Hagedorn, I. 1978, Arzneim-Forsch., 28, 2055-2057.
9. van Helden, H. P. M., Busker, R. W., Melchers, B. P. C., and Bruijnzeel, P. L. B. 1996, Arch. Toxicol., 70, 779-786.
10. Fleisher, J. H., and Harris, L. W. 1965, Biochem. Pharmacol., 14, 641-650.
11. Clement, J. G. 1981, Fundam. Appl. Toxicol., 1, 193-202.
12. Tušarová, I., and Halámek, E. 2001, Patent ČR 288 576.