메뉴 건너뛰기




Volumn 11, Issue 3, 2008, Pages 201-207

Regulation of adipose tissue metabolism in cancer cachexia

Author keywords

Adipose tissue; Cachexia; Cancer; Lipid metabolism; Mediators of fat loss; Zinc 2 glycoprotein

Indexed keywords

ADIPOCYTOKINE; ALPHA2 GLYCOPROTEIN; TUMOR NECROSIS FACTOR ALPHA; ZINC;

EID: 42149118391     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3282f948e2     Document Type: Review
Times cited : (39)

References (58)
  • 1
    • 34447541405 scopus 로고    scopus 로고
    • Pathophysiology of cancer cachexia: Much more than host-tumour interaction?
    • A review on the pathogenesis of cancer cachexia particularly the patient factors in addition to the interactions between the host and the tumour
    • Skipworth RJC, Stewart GD, Dejong CHC, et al. Pathophysiology of cancer cachexia: much more than host-tumour interaction? Clin Nutr 2007; 83:667-676. A review on the pathogenesis of cancer cachexia particularly the patient factors in addition to the interactions between the host and the tumour.
    • (2007) Clin Nutr , vol.83 , pp. 667-676
    • Skipworth, R.J.C.1    Stewart, G.D.2    Dejong, C.H.C.3
  • 2
    • 33646674302 scopus 로고    scopus 로고
    • Cachexia: Pathophysiology and clinical relevance
    • Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr 2006; 83:735-743.
    • (2006) Am J Clin Nutr , vol.83 , pp. 735-743
    • Morley, J.E.1    Thomas, D.R.2    Wilson, M.M.3
  • 3
    • 0344628796 scopus 로고    scopus 로고
    • Baseline nutritional assessment in advanced cancer patients receiving palliative chemotherapy
    • Slaviero KA, Read JA, Clarke SJ, Rivory LP. Baseline nutritional assessment in advanced cancer patients receiving palliative chemotherapy. Nutr Cancer 2003; 46:148-157.
    • (2003) Nutr Cancer , vol.46 , pp. 148-157
    • Slaviero, K.A.1    Read, J.A.2    Clarke, S.J.3    Rivory, L.P.4
  • 4
    • 26844582185 scopus 로고    scopus 로고
    • Molecular pathways leading to cancer cachexia
    • Tisdale MJ. Molecular pathways leading to cancer cachexia. Physiology (Bethesda) 2005; 20:340-348.
    • (2005) Physiology (Bethesda) , vol.20 , pp. 340-348
    • Tisdale, M.J.1
  • 5
    • 33845343993 scopus 로고    scopus 로고
    • Anorexia in cancer: Role of feeding-regulatory peptides
    • Perboni S, Inui A. Anorexia in cancer: role of feeding-regulatory peptides. Philos Trans R Soc Lond B Biol Sci 2006; 361:1281-1289.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1281-1289
    • Perboni, S.1    Inui, A.2
  • 6
    • 33846594415 scopus 로고    scopus 로고
    • Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats
    • The work suggests dysfunction of NPY feeding systems in experimental cancer anorexia
    • Chance WT, Xiao C, Dayal R, Sheriff S. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. Peptides 2007; 28:295-301. The work suggests dysfunction of NPY feeding systems in experimental cancer anorexia.
    • (2007) Peptides , vol.28 , pp. 295-301
    • Chance, W.T.1    Xiao, C.2    Dayal, R.3    Sheriff, S.4
  • 7
    • 0035866377 scopus 로고    scopus 로고
    • Role of the central melanocortin system in cachexia
    • Marks DL, Ling N, Cone RD. Role of the central melanocortin system in cachexia. Cancer Res 2001; 61:1432-1438.
    • (2001) Cancer Res , vol.61 , pp. 1432-1438
    • Marks, D.L.1    Ling, N.2    Cone, R.D.3
  • 8
    • 0035212781 scopus 로고    scopus 로고
    • Cachexia in MAC16 adenocarcinoma: Suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y
    • Bing C, Taylor S, Tisdale MJ, Williams G. Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y. J Neurochem 2001; 79:1004-1012.
    • (2001) J Neurochem , vol.79 , pp. 1004-1012
    • Bing, C.1    Taylor, S.2    Tisdale, M.J.3    Williams, G.4
  • 9
    • 32544440799 scopus 로고    scopus 로고
    • Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients
    • Wolf I, Sadetzki S, Kanety H, et al. Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients. Cancer 2006; 106:966-973.
    • (2006) Cancer , vol.106 , pp. 966-973
    • Wolf, I.1    Sadetzki, S.2    Kanety, H.3
  • 10
    • 35948981520 scopus 로고    scopus 로고
    • Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1
    • This study demonstrated that serum MIC-1 correlates with cancer cachexia in patients, and this is due to its anorexic action mediated by hypothalamic neuropeptides and signal transduction. The findings suggest that MIC-1 is a newly defined central regulator of appetite and a potential target for the treatment of cancer cachexia
    • Johnen H, Lin S, Kuffner T, et al. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med 2007; 13:1333-1340. This study demonstrated that serum MIC-1 correlates with cancer cachexia in patients, and this is due to its anorexic action mediated by hypothalamic neuropeptides and signal transduction. The findings suggest that MIC-1 is a newly defined central regulator of appetite and a potential target for the treatment of cancer cachexia.
    • (2007) Nat Med , vol.13 , pp. 1333-1340
    • Johnen, H.1    Lin, S.2    Kuffner, T.3
  • 11
    • 0034904166 scopus 로고    scopus 로고
    • Do patients with nonmetastatic nonsmall cell lung cancer demonstrate altered resting energy expenditure?
    • Jatoi A, Daly BD, Hughes VA, et al. Do patients with nonmetastatic nonsmall cell lung cancer demonstrate altered resting energy expenditure? Ann Thorac Surg 2001; 72:348-351.
    • (2001) Ann Thorac Surg , vol.72 , pp. 348-351
    • Jatoi, A.1    Daly, B.D.2    Hughes, V.A.3
  • 12
    • 34547520749 scopus 로고    scopus 로고
    • Colorectal cancer: Intrinsic characteristics modulate cancer energy expenditure and the risk of cachexia
    • Describes a longitudinal study on resting energy expenditure in colorectal cancer patients
    • Ravasco P, Monteiro-Grillo I, Camilo M. Colorectal cancer: intrinsic characteristics modulate cancer energy expenditure and the risk of cachexia. Cancer Invest 2007; 25:308-314. Describes a longitudinal study on resting energy expenditure in colorectal cancer patients.
    • (2007) Cancer Invest , vol.25 , pp. 308-314
    • Ravasco, P.1    Monteiro-Grillo, I.2    Camilo, M.3
  • 13
    • 0034194239 scopus 로고    scopus 로고
    • Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia
    • Bing C, Brown M, King P, et al. Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia. Cancer Res 2000; 60:2405-2410.
    • (2000) Cancer Res , vol.60 , pp. 2405-2410
    • Bing, C.1    Brown, M.2    King, P.3
  • 14
    • 0022602643 scopus 로고
    • Brown adipose tissue in cancer patients: Possible cause of cancer-induced cachexia
    • Shellock FG, Riedinger MS, Fishbein MC. Brown adipose tissue in cancer patients: possible cause of cancer-induced cachexia. J Cancer Res Clin Oncol 1986; 111:82-85.
    • (1986) J Cancer Res Clin Oncol , vol.111 , pp. 82-85
    • Shellock, F.G.1    Riedinger, M.S.2    Fishbein, M.C.3
  • 15
    • 0036473176 scopus 로고    scopus 로고
    • Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans
    • Collins P, Bing C, McCulloch P, Williams G. Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans. Br J Cancer 2002; 86:372-375.
    • (2002) Br J Cancer , vol.86 , pp. 372-375
    • Collins, P.1    Bing, C.2    McCulloch, P.3    Williams, G.4
  • 16
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004; 92:347-355.
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 17
    • 33750215437 scopus 로고    scopus 로고
    • Appetite and energy balance signals from adipocytes
    • Trayhurn P, Bing C. Appetite and energy balance signals from adipocytes. Philos Trans R Soc Lond B Biol Sci 2006; 361:1237-1249.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1237-1249
    • Trayhurn, P.1    Bing, C.2
  • 18
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444:847-853.
    • (2006) Nature , vol.444 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 19
    • 0028095382 scopus 로고
    • Diminished visceral adipose tissue in cancer cachexia
    • Ogiwara H, Takahashi S, Kato Y, et al. Diminished visceral adipose tissue in cancer cachexia. J Surg Oncol 1994; 57:129-133.
    • (1994) J Surg Oncol , vol.57 , pp. 129-133
    • Ogiwara, H.1    Takahashi, S.2    Kato, Y.3
  • 20
    • 18044361914 scopus 로고    scopus 로고
    • Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care - correlations with food intake, metabolism, exercise capacity, and hormones
    • Fouladiun M, Korner U, Bosaeus I, et al. Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care - correlations with food intake, metabolism, exercise capacity, and hormones. Cancer 2005; 103:2189-2198.
    • (2005) Cancer , vol.103 , pp. 2189-2198
    • Fouladiun, M.1    Korner, U.2    Bosaeus, I.3
  • 21
    • 0025353027 scopus 로고
    • Body composition in cancer cachexia
    • Fearon KC, Preston T. Body composition in cancer cachexia. Infusionstherapie 1990; 17 (Suppl 3):63-66.
    • (1990) Infusionstherapie , vol.17 , Issue.SUPPL. 3 , pp. 63-66
    • Fearon, K.C.1    Preston, T.2
  • 22
    • 34250633536 scopus 로고    scopus 로고
    • Risk factor paradox in wasting diseases
    • A comprehensive review on the paradox of conventional risk factors related to better survival in wasting syndromes, which has clinical importance regarding intervention strategies
    • Kalantar-Zadeh K, Horwich TB, Oreopoulos A, et al. Risk factor paradox in wasting diseases. Curr Opin Clin Nutr Metab Care 2007; 10:433-442. A comprehensive review on the paradox of conventional risk factors related to better survival in wasting syndromes, which has clinical importance regarding intervention strategies.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 433-442
    • Kalantar-Zadeh, K.1    Horwich, T.B.2    Oreopoulos, A.3
  • 23
    • 34648825008 scopus 로고    scopus 로고
    • Inverse correlation between body mass index and clinical outcomes in men with advanced castration-recurrent prostate cancer
    • This clinical study shows that a higher BMI is associated with better survival in patients with metastatic castration-recurrent prostate cancer; hence it identifies an obesity paradox in cancer patients
    • Halabi S, Ou SS, Vogelzang NJ, Small EJ. Inverse correlation between body mass index and clinical outcomes in men with advanced castration-recurrent prostate cancer. Cancer 2007; 110:1478-1484. This clinical study shows that a higher BMI is associated with better survival in patients with metastatic castration-recurrent prostate cancer; hence it identifies an obesity paradox in cancer patients.
    • (2007) Cancer , vol.110 , pp. 1478-1484
    • Halabi, S.1    Ou, S.S.2    Vogelzang, N.J.3    Small, E.J.4
  • 24
    • 33750217510 scopus 로고    scopus 로고
    • Adipose atrophy in cancer cachexia: Morphologic and molecular analysis of adipose tissue in tumour-bearing mice
    • Bing C, Russell S, Becket E, et al. Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice. Br J Cancer 2006; 95:1028-1037.
    • (2006) Br J Cancer , vol.95 , pp. 1028-1037
    • Bing, C.1    Russell, S.2    Becket, E.3
  • 25
    • 0034235124 scopus 로고    scopus 로고
    • Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects
    • Zuijdgeest-van Leeuwen SD, van den Berg JW, Wattimena JL, et al. Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects. Metabolism 2000; 49:931-936.
    • (2000) Metabolism , vol.49 , pp. 931-936
    • Zuijdgeest-van Leeuwen, S.D.1    van den Berg, J.W.2    Wattimena, J.L.3
  • 26
    • 34347242117 scopus 로고    scopus 로고
    • Agustsson T, Ryden M, Hoffstedt J, et al. Mechanism of increased lipolysis in cancer cachexia. Cancer Res 2007; 67:5531-5537. This study found significantly increased lipolysis in isolated adipocytes in cancer patients with cachexia, and this is attributable to enhanced expression and activity of hormone-sensitive lipase. Thus, inhibition of this enzyme may prevent or reverse fat loss in cancer patients
    • Agustsson T, Ryden M, Hoffstedt J, et al. Mechanism of increased lipolysis in cancer cachexia. Cancer Res 2007; 67:5531-5537. This study found significantly increased lipolysis in isolated adipocytes in cancer patients with cachexia, and this is attributable to enhanced expression and activity of hormone-sensitive lipase. Thus, inhibition of this enzyme may prevent or reverse fat loss in cancer patients.
  • 27
    • 0027526182 scopus 로고
    • Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients
    • Thompson MP, Cooper ST, Parry BR, Tuckey JA. Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. Biochim Biophys Acta 1993; 1180:236-242.
    • (1993) Biochim Biophys Acta , vol.1180 , pp. 236-242
    • Thompson, M.P.1    Cooper, S.T.2    Parry, B.R.3    Tuckey, J.A.4
  • 28
    • 0019513846 scopus 로고
    • Modified lipoprotein lipase activities, rates of lipogenesis, and lipolysis as factors leading to lipid depletion in C57BL mice bearing the preputial gland tumor, ESR-586
    • Thompson MP, Koons JE, Tan ET, Grigor MR. Modified lipoprotein lipase activities, rates of lipogenesis, and lipolysis as factors leading to lipid depletion in C57BL mice bearing the preputial gland tumor, ESR-586. Cancer Res 1981; 41:3228-3232.
    • (1981) Cancer Res , vol.41 , pp. 3228-3232
    • Thompson, M.P.1    Koons, J.E.2    Tan, E.T.3    Grigor, M.R.4
  • 29
    • 0028880016 scopus 로고
    • Perturbations of triglycerides but not of cholesterol metabolism are prevented by antitumour necrosis factor treatment in rats bearing an ascites hepatoma (Yoshida AH-130)
    • Dessi S, Batetta B, Spano O, et al. Perturbations of triglycerides but not of cholesterol metabolism are prevented by antitumour necrosis factor treatment in rats bearing an ascites hepatoma (Yoshida AH-130). Br J Cancer 1995; 72:1138-1143.
    • (1995) Br J Cancer , vol.72 , pp. 1138-1143
    • Dessi, S.1    Batetta, B.2    Spano, O.3
  • 30
    • 0030659587 scopus 로고    scopus 로고
    • Insulin resistance and the alterations of glucose transporter-4 in adipose cells from cachectic tumor-bearing rats
    • Yoshikawa T, Noguchi Y, Satoh S, et al. Insulin resistance and the alterations of glucose transporter-4 in adipose cells from cachectic tumor-bearing rats. JPEN J Parenter Enteral Nutr 1997; 21:347-349.
    • (1997) JPEN J Parenter Enteral Nutr , vol.21 , pp. 347-349
    • Yoshikawa, T.1    Noguchi, Y.2    Satoh, S.3
  • 31
    • 0022370580 scopus 로고
    • Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: The role of cachectin (tumor necrosis factor)
    • Cerami A, Ikeda Y, Le Trang N, et al. Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor). Immunol Lett 1985; 11:173-177.
    • (1985) Immunol Lett , vol.11 , pp. 173-177
    • Cerami, A.1    Ikeda, Y.2    Le Trang, N.3
  • 32
    • 39049133455 scopus 로고    scopus 로고
    • TNF-alpha modulates human in vivo lipolysis
    • study demonstrated that infusion of a relatively low dose of recombinant human TNFα induces systemic lipolysis in healthy individuals without affecting skeletal muscle lipid metabolism. The finding suggests that TNFα may play a role in the mediation of dyslipidemia in chronic disease, doi:10.1210/jc.2007-1761. This
    • Plomgaard P, Fischer CP, Ibfelt T, et al. TNF-alpha modulates human in vivo lipolysis. J Clin Endocrinol Metab 2007; doi:10.1210/jc.2007-1761. This study demonstrated that infusion of a relatively low dose of recombinant human TNFα induces systemic lipolysis in healthy individuals without affecting skeletal muscle lipid metabolism. The finding suggests that TNFα may play a role in the mediation of dyslipidemia in chronic disease.
    • (2007) J Clin Endocrinol Metab
    • Plomgaard, P.1    Fischer, C.P.2    Ibfelt, T.3
  • 33
    • 38049126070 scopus 로고    scopus 로고
    • Yang JY, Koo JH, Yoon HY, et al. Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes. Int J Mol Med 2007; 20:527-531. Reports that TNFα-induced suppression of LPL activity can be partially reversed by scopoletin.
    • Yang JY, Koo JH, Yoon HY, et al. Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes. Int J Mol Med 2007; 20:527-531. Reports that TNFα-induced suppression of LPL activity can be partially reversed by scopoletin.
  • 34
    • 34548628330 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha in human adipose tissue - from signalling mechanisms to clinical implications
    • A detailed review on the role of TNFα in human white fat, particularly its regulation of lipolysis, an important metabolic event in adipocytes since it links to body fat mass and insulin resistance
    • Ryden M, Arner P. Tumour necrosis factor-alpha in human adipose tissue - from signalling mechanisms to clinical implications. J Intern Med 2007; 262:431-438. A detailed review on the role of TNFα in human white fat, particularly its regulation of lipolysis, an important metabolic event in adipocytes since it links to body fat mass and insulin resistance.
    • (2007) J Intern Med , vol.262 , pp. 431-438
    • Ryden, M.1    Arner, P.2
  • 35
    • 34247551878 scopus 로고    scopus 로고
    • Wnt-signaling is maintained and adipogenesis inhibited by TNFa but not MCP-1 and resistin
    • The study suggests that TNFα acts on Wnt-signaling to inhibit adipogenesis
    • Hammarstedt A, Isakson P, Gustafson B, et al. Wnt-signaling is maintained and adipogenesis inhibited by TNFa but not MCP-1 and resistin. Biochem Biophys Res Commun 2007; 357:700-706. The study suggests that TNFα acts on Wnt-signaling to inhibit adipogenesis.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 700-706
    • Hammarstedt, A.1    Isakson, P.2    Gustafson, B.3
  • 36
    • 34250748977 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway
    • This study illustrated the mechanisms underlying inhibitory effect of TNFα on adipocyte differentiation. The data suggest that TNFα-induced antiadipogenesis is via a Wnt/beta-catenin/TCF4-dependent pathway
    • Cawthorn WP, Heyd F, Hegyi K, et al. Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death Differ 2007; 14:1361-1373. This study illustrated the mechanisms underlying inhibitory effect of TNFα on adipocyte differentiation. The data suggest that TNFα-induced antiadipogenesis is via a Wnt/beta-catenin/TCF4-dependent pathway.
    • (2007) Cell Death Differ , vol.14 , pp. 1361-1373
    • Cawthorn, W.P.1    Heyd, F.2    Hegyi, K.3
  • 37
    • 33746736936 scopus 로고    scopus 로고
    • Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
    • Lagathu C, Yvan-Charvet L, Bastard JP, et al. Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 2006; 49:2162-2173.
    • (2006) Diabetologia , vol.49 , pp. 2162-2173
    • Lagathu, C.1    Yvan-Charvet, L.2    Bastard, J.P.3
  • 38
    • 33746786929 scopus 로고    scopus 로고
    • Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients
    • Kayacan O, Karnak D, Beder S, et al. Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients. Am J Clin Oncol 2006; 29:328-335.
    • (2006) Am J Clin Oncol , vol.29 , pp. 328-335
    • Kayacan, O.1    Karnak, D.2    Beder, S.3
  • 39
    • 12344305118 scopus 로고    scopus 로고
    • Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patients
    • Iwase S, Murakami T, Saito Y, Nakagawa K. Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patients. Eur Cytokine Netw 2004; 15:312-316.
    • (2004) Eur Cytokine Netw , vol.15 , pp. 312-316
    • Iwase, S.1    Murakami, T.2    Saito, Y.3    Nakagawa, K.4
  • 40
    • 38449085115 scopus 로고    scopus 로고
    • Fortunati N, Manti R, Birocco N, et al. Pro-inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients. Oncol Rep 2007; 18:1521-1527. This paper reported a significant increase in serum TNFa, and oxidative stress/antioxidant parameters in lung cancer patients with cachexia, suggesting that the bio-humoral profile could be used for the early diagnosis and follow-up of the syndrome.
    • Fortunati N, Manti R, Birocco N, et al. Pro-inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients. Oncol Rep 2007; 18:1521-1527. This paper reported a significant increase in serum TNFa, and oxidative stress/antioxidant parameters in lung cancer patients with cachexia, suggesting that the bio-humoral profile could be used for the early diagnosis and follow-up of the syndrome.
  • 41
    • 12644298682 scopus 로고    scopus 로고
    • Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients
    • Maltoni M, Fabbri L, Nanni O, et al. Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients. Support Care Cancer 1997; 5:130-135.
    • (1997) Support Care Cancer , vol.5 , pp. 130-135
    • Maltoni, M.1    Fabbri, L.2    Nanni, O.3
  • 42
    • 8744267483 scopus 로고    scopus 로고
    • Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro
    • Trujillo ME, Sullivan S, Harten I, et al. Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro. J Clin Endocrinol Metab 2004; 89:5577-5582.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5577-5582
    • Trujillo, M.E.1    Sullivan, S.2    Harten, I.3
  • 43
    • 3843139682 scopus 로고    scopus 로고
    • CNTO 328, a monoclonal antibody to IL-6, inhibits human tumor-induced cachexia in nude mice
    • Zaki MH, Nemeth JA, Trikha M. CNTO 328, a monoclonal antibody to IL-6, inhibits human tumor-induced cachexia in nude mice. Int J Cancer 2004; 111:592-595.
    • (2004) Int J Cancer , vol.111 , pp. 592-595
    • Zaki, M.H.1    Nemeth, J.A.2    Trikha, M.3
  • 44
    • 36749087038 scopus 로고    scopus 로고
    • Richey LM, George JR, Couch ME, et al. Defining cancer cachexia in head and neck squamous cell carcinoma. Clin Cancer Res 2007; 13:6561-6567. The authors identified that in addition to T(4) status, elevated C-reactive protein and decreased hemoglobin, increased serum IL-6 is associated with cancer cachexia in patients with head and neck squamous cell carcinoma.
    • Richey LM, George JR, Couch ME, et al. Defining cancer cachexia in head and neck squamous cell carcinoma. Clin Cancer Res 2007; 13:6561-6567. The authors identified that in addition to T(4) status, elevated C-reactive protein and decreased hemoglobin, increased serum IL-6 is associated with cancer cachexia in patients with head and neck squamous cell carcinoma.
  • 45
    • 36348976492 scopus 로고    scopus 로고
    • Krzystek-Korpacka M, Matusiewicz M, Diakowska D, et al. Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients. Clin Biochem 2007; 40:1353-1360. Report that upregulation of IL-6 and IL-8 may contribute to the development of cachexia in gastroesophageal malignancies.
    • Krzystek-Korpacka M, Matusiewicz M, Diakowska D, et al. Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients. Clin Biochem 2007; 40:1353-1360. Report that upregulation of IL-6 and IL-8 may contribute to the development of cachexia in gastroesophageal malignancies.
  • 46
    • 33846519859 scopus 로고    scopus 로고
    • Kuroda K, Nakashima J, Kanao K, et al. Interleukin 6 is associated with cachexia in patients with prostate cancer. Urology 2007; 69:113-117. This study found that high levels of serum IL-6 was associated with low serum total protein, cholesterol and hemoglobin levels, and reduced BMI, but increased mortality rate in prostate cancer patients.
    • Kuroda K, Nakashima J, Kanao K, et al. Interleukin 6 is associated with cachexia in patients with prostate cancer. Urology 2007; 69:113-117. This study found that high levels of serum IL-6 was associated with low serum total protein, cholesterol and hemoglobin levels, and reduced BMI, but increased mortality rate in prostate cancer patients.
  • 47
    • 4344656133 scopus 로고    scopus 로고
    • Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients
    • Jan V, Cervera P, Maachi M, et al. Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients. Antivir Ther 2004; 9:555-564.
    • (2004) Antivir Ther , vol.9 , pp. 555-564
    • Jan, V.1    Cervera, P.2    Maachi, M.3
  • 48
    • 0027176082 scopus 로고
    • Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters
    • Diez-Itza I, Sanchez LM, Allende MT, et al. Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters. Eur J Cancer 1993; 29A:1256-1260.
    • (1993) Eur J Cancer , vol.29 A , pp. 1256-1260
    • Diez-Itza, I.1    Sanchez, L.M.2    Allende, M.T.3
  • 49
    • 0034896402 scopus 로고    scopus 로고
    • Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer
    • Hale LP, Price DT, Sanchez LM, et al. Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer. Clin Cancer Res 2001; 7:846-853.
    • (2001) Clin Cancer Res , vol.7 , pp. 846-853
    • Hale, L.P.1    Price, D.T.2    Sanchez, L.M.3
  • 50
    • 34147211128 scopus 로고    scopus 로고
    • LC-MS/MS Quantification of Zn-{alpha}2 Glycoprotein: A potential serum biomarker for prostate cancer
    • This paper describes a high-flow liquid chromatography-tandem mass spectrometry method for measuring serum ZAG concentrations, and reported that circulating ZAG are increased in patients with prostate cancer
    • Bondar OP, Barnidge DR, Klee EW, et al. LC-MS/MS Quantification of Zn-{alpha}2 Glycoprotein: a potential serum biomarker for prostate cancer. Clin Chem 2007; 53:673-678. This paper describes a high-flow liquid chromatography-tandem mass spectrometry method for measuring serum ZAG concentrations, and reported that circulating ZAG are increased in patients with prostate cancer.
    • (2007) Clin Chem , vol.53 , pp. 673-678
    • Bondar, O.P.1    Barnidge, D.R.2    Klee, E.W.3
  • 51
    • 0032101680 scopus 로고    scopus 로고
    • Purification and characterization of a tumor lipid-mobilizing factor
    • Todorov PT, McDevitt TM, Meyer DJ, et al. Purification and characterization of a tumor lipid-mobilizing factor. Cancer Res 1998; 58:2353-2358.
    • (1998) Cancer Res , vol.58 , pp. 2353-2358
    • Todorov, P.T.1    McDevitt, T.M.2    Meyer, D.J.3
  • 52
    • 0032100584 scopus 로고    scopus 로고
    • Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients
    • Hirai K, Hussey HJ, Barber MD, et al. Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients. Cancer Res 1998; 58:2359-2365.
    • (1998) Cancer Res , vol.58 , pp. 2359-2365
    • Hirai, K.1    Hussey, H.J.2    Barber, M.D.3
  • 53
    • 0037065968 scopus 로고    scopus 로고
    • Expression of uncoupling proteins-1, -2 and -3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor
    • Bing C, Russell ST, Beckett EE, et al. Expression of uncoupling proteins-1, -2 and -3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor. Br J Cancer 2002; 86:612-618.
    • (2002) Br J Cancer , vol.86 , pp. 612-618
    • Bing, C.1    Russell, S.T.2    Beckett, E.E.3
  • 54
    • 0036462520 scopus 로고    scopus 로고
    • Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor
    • Russell ST, Hirai K, Tisdale MJ. Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor. Br J Cancer 2002; 86:424-428.
    • (2002) Br J Cancer , vol.86 , pp. 424-428
    • Russell, S.T.1    Hirai, K.2    Tisdale, M.J.3
  • 55
    • 1442330395 scopus 로고    scopus 로고
    • Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
    • Bing C, Bao Y, Jenkins J, et al. Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci USA 2004; 101:2500-2505.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2500-2505
    • Bing, C.1    Bao, Y.2    Jenkins, J.3
  • 56
    • 11144279499 scopus 로고    scopus 로고
    • Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes
    • Bao Y, Bing C, Hunter L, et al. Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett 2005; 579:41-47.
    • (2005) FEBS Lett , vol.579 , pp. 41-47
    • Bao, Y.1    Bing, C.2    Hunter, L.3
  • 57
    • 26244440545 scopus 로고    scopus 로고
    • A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects
    • Dahlman I, Kaaman M, Olsson T, et al. A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 2005; 90:5834-5840.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5834-5840
    • Dahlman, I.1    Kaaman, M.2    Olsson, T.3
  • 58
    • 33846476230 scopus 로고    scopus 로고
    • Rolli V, Radosavljevic M, Astier V, et al. Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett 2007; 581:394-400. The authors developed knockout mice for zinc-alpha2-glycoprotein and demonstrated the functional significance of the protein in the regulation of body fat. Their work has shown that mice without the protein are susceptible to weight gain on a high-fat diet, probably due to a marked reduction in lipolysis.
    • Rolli V, Radosavljevic M, Astier V, et al. Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett 2007; 581:394-400. The authors developed knockout mice for zinc-alpha2-glycoprotein and demonstrated the functional significance of the protein in the regulation of body fat. Their work has shown that mice without the protein are susceptible to weight gain on a high-fat diet, probably due to a marked reduction in lipolysis.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.