Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis

Shock

Volumn 29, Issue 5, 2008, Pages 642-649

  Enkhbaatar, Perenlei ^a   Joncam, Collette ^a   Traber, Lillian ^a   Nakano, Yoshimitsu ^a   Wang, Jianpu ^a   Lange, Matthias ^a   Connelly, Rhykka ^a   Kulp, Gabriela ^b   Saunders, Fiona ^a   Huda, Ruksana ^a   Cox, Robert ^b   Schmalstieg, Frank ^a   Herndon, David ^b   Traber, Daniel ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Pneumonia; Sepsis; Smoke

Indexed keywords

CYTOKINE; MYELOPEROXIDASE; NITRATE; NITRITE; PLASMA PROTEIN; REACTIVE NITROGEN SPECIES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL PNEUMONIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DISEASE SIMULATION; ENZYME ACTIVITY; FEMALE; FLUID RETENTION; HEART LEFT ATRIUM PRESSURE; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMATOCRIT; HYPOTENSION; LUNG BURN; LUNG FLUID; LUNG GAS EXCHANGE; LUNG PRESSURE; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIPLE ORGAN FAILURE; NONHUMAN; ONCOTIC PRESSURE; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; REPRODUCIBILITY; RESUSCITATION; SEPSIS; SHEEP; SYSTEMIC VASCULAR RESISTANCE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HEMATOCRIT; HEMODYNAMICS; LUNG; METHICILLIN; METHICILLIN RESISTANCE; PNEUMONIA; SEPSIS; SHEEP; SMOKE INHALATION INJURY; STAPHYLOCOCCUS AUREUS; TIME FACTORS; TYROSINE;

EID: 42149085712     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318158125b     Document Type: Article

References (32)

1. Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, Dean N, File T, Fine MJ, Gross PA, et al.: Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 163:1730-1754, 2001.
2. Lynch JP: Hospital-acquired pneumonia: risk factors, microbiology, and treatment. Chest 119:373S-384S, 2001. Review.
3. Kollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, Johannes RS: Epidemiology and outcomes of health-care-associated pneumonia. Chest 128:3854-3859, 2005.
4. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2003. Issued August 2003. Am J Infect Control 31:481-498, 2003.
5. Rello J, Torres A, Ricart M, Valles J, Gonzalez J, Artigas A, Rodriguez-Roisin R: Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med 150:1545-1549, 1994.
6. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992-June 2001, issued August 2001. Am J Infect Control 29:404-421, 2001.
7. Entenza JM, Drugeon H, Glauser MP, Moreillon P: Treatment of experimental endocarditis due to erythromycin-susceptible or -resistant methicillin- resistant Staphylococcus aureus with RP 59500. Antimicrob Agents Chemother 39:1419-1424, 1995.
8. Cox RA, Burke AS, Soejima K, Murakami K, Katahira J, Traber LD, Herndon DN, Schmalstieg FC, Traber DL, Hawkins HK: Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Respir Cell Mol Biol 29:295-302, 2003.
9. Enkhbaatar P, Murakami K, Traber LD, Cox R, Parkinson JF, Westphal M, Esechie A, Morita N, Maybauer MO, Maybauer DM, et al.: The inhibition of inducible nitric oxide synthase in ovine sepsis model. Shock 25:522-527, 2006.
10. Pearce ML, Yamashita J, Beazell J: Measurement of pulmonary edema. Circ Res 16:482-488, 1965.
11. Gillett AM, Wallace MJ, Gillespie MT, Hooper SB: Increased expansion of the lung stimulates calmodulin 2 expression in fetal sheep. Am J Physiol Lung Cell Mol Physiol 282:L440-L447, 2002.
12. Hollingsworth JW, Chen BJ, Brass DM, Berman K, Gunn MD, Cook DN, Schwartz DA: The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. Am J Respir Crit Care Med 171:806-813, 2005.
13. Chambers HF: The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis 7:178-182, 2001.
14. Deresinski S: Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey. Clin Infect Dis 40:562-573, 2005.
15. Murakami K, Bjertnaes LJ, Schmalstieg FC, McGuire R, Cox RA, Hawkins HK, Herndon DN, Traber LD, Traber DL: A novel animal model of sepsis after acute lung injury in sheep. Crit Care Med 30:2083-2090, 2002.
16. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, McGuire R, Schmalstieg F, Cox R, Hawkins H, Jodoin J, Lee S, et al.: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. Am J Physiol Regul Integr Comp Physiol 285:R366-R372, 2003.
17. Moncada SR, Palmer MJ, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142, 1991.
18. Schulz R, Nava E, Moncada S: Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium. Br J Pharmacol 105:575-580, 1992.
19. Rumbaut RE, Wang J, Huxley VH: Differential effects of 1-NAME on rat venular hydraulic conductivity. Am J Physiol Heart Circ Physiol 279, H2017-H2023, 2000.
20. Rumbaut RE, Huxley VH: Similar permeability responses to nitric oxide synthase inhibitors of venules from three animal species. Microvasc Res 64:21-31, 2002.
21. Huang Q, Yuan Y: Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability. Am J Physiol Heart Circ Physiol 273:H2442-H2451, 1997.
22. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips GB, Parkinson JF, Cox R, Hawkins H, Herndon D, et al.: The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am J Respir Crit Care Med 167:1021-1026, 2003.
23. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips G, Parkinson J, Salsbury JR, Biondo N, Schmalstieg F, et al.: Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury. Am J Physiol Heart Circ Physiol 285:H2430-H2436, 2003.
24. Szabo C: Poly(ADP-ribose) polymerase activation by reactive nitrogen species - relevance for the pathogenesis of inflammation. Nitric Oxide 14:169-179, 2006. Review.
25. Gomez-jimenez J, Salgado A, Mourelle M, Martin MC, Segura RM, Peracaula R, Moncada S: 1-Arginine: nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med 23:253Y258, 1995.
26. Remick DG, Bolgos GR, Siddiqui J, Shin J, Nemzek JA: Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days. Shock 17:463-467, 2002.
27. Szabo C, Dawson VI: Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 19:287-298, 1998.
28. Hauser B, Groger M, Ehrmann U, Albicini M, Bruckner UB, Schelzig H, Venkatesh B, Li H, Szabo C, Speit G, et al.: The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion. Shock 25:633-640, 2006.
29. Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, et al.: Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 21:126-133, 2004.
30. Battafarano RJ, Dunn DL: Role of nitric oxide during sepsis. Crit Care Med 20:1504-1505, 1992.
31. Evans T, Carpenter A, Kinderman H, Cohen J: Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 41:77-81, 1993.
32. Cobb JP, Danner RL: Nitric oxide and septic shock. JAMA 275:1992-1996, 1996.