Enantioselective synthesis of the PPARα agonist (R)-K-13675 via (S)-2-hydroxybutyrolactone

Synthesis

Volumn , Issue 7, 2008, Pages 1017-1022

  Yamazaki, Yukiyoshi ^a   Araki, Takaaki ^a   Koura, Minoru ^a   Shibuya, Kimiyuki ^a  

^a KOWA COMPANY LTD   (Japan)

Author keywords

Enantioselective synthesis; Ethers; Mitsunobu reaction; PPAR agonist; Ring opening

Indexed keywords

ENANTIOSELECTIVE SYNTHESIS; MITSUNOBU REACTION; RING OPENING;

ENANTIOMERS; ENANTIOSELECTIVITY; HYDROLYSIS;

ETHERS;

2 (ARYLOXY) 4 IODOBUTANOIC ACID; 2 (ARYLOXY)BUTANOIC ACID; 2 (ARYLOXY)BUTYROLACTONE; 2 HYDROXYBUTYROLACTONE; BUTYRIC ACID; BUTYROLACTONE; IODOTRIMETHYLSILANE; K 13675; LACTONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHENOL; SILANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HYDROGENOLYSIS; HYDROLYSIS; MITSUNOBU REACTION; RING OPENING;

EID: 42049123629     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1032123     Document Type: Article

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