Endocrinology of cluster headache: Potential for therapeutic manipulation

Current Pain and Headache Reports

Volumn 12, Issue 2, 2008, Pages 138-144

  Stillman, Mark ^a   Spears, Roderick ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CORTICOSTEROID; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; ESTRADIOL; FOLLITROPIN; GONADORELIN; LEUPRORELIN; LUTEINIZING HORMONE; MELATONIN; METHYLPREDNISOLONE; OXYGEN; PREDNISOLONE; PREDNISONE; SEROTONIN AGONIST; TESTOSTERONE;

ALOPECIA; CIRCADIAN RHYTHM; CLUSTER HEADACHE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG MEGADOSE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS LESION; INJECTION SITE ATROPHY; LIBIDO; NERVOUS SYSTEM INFLAMMATION; NEUROENDOCRINOLOGY; NEUROIMAGING; PATHOPHYSIOLOGY; PRIMARY HEADACHE; REVIEW; SEX DIFFERENCE; SIDE EFFECT; TRIGEMINAL AUTONOMIC CEPHALALGIA; VIRILIZATION;

ADRENAL CORTEX HORMONES; AUTONOMIC NERVOUS SYSTEM DISEASES; CLUSTER HEADACHE; ENDOCRINOLOGY; GONADAL STEROID HORMONES; HUMANS; MELATONIN;

EID: 42049120463     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-008-0026-1     Document Type: Review

References (50)

1. Symonds C: A particular variety of headache. Brain 1956, 79:217-232.
2. Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004, 24(Suppl 1):9-160.
3. Hardebo JE: How cluster headache is explained as an intracavernous inflammatory process lesioning sympathetic fibers. Headache 1994, 34:125-131.
4. Hannerz J: Orbital phlebography and signs of inflammation in episodic and chronic cluster headache. Headache 1991, 31:540-542.
5. Hannerz J, Ericson K, Bergstrand G: Orbital phlebography in patients with cluster headaches. Cephalalgia 1987, 7:207-211.
6. Remahl IN, Waldenlind E, Bratt J, Ekbom K: Cluster headache is not associated with signs of a systemic inflammation. Headache 2000, 40:276-280.
7. Empl M, Fordeneuther S, Schwarz M, et al.: Soluble interleukin-2 receptors increase during active periods of cluster headache. Headache 2003, 43:63-68.
8. Martelletti R, Stirpano G, DeStefano L, et al.: Defective expression of IL-2 receptors on peripheral blood lymphocytes from patients with cluster headache. Headache 1990, 30:228-231.
9. Rasmussen BK: Epidemiology of cluster headache. In Cluster Headache and Related Conditions. Edited by Olesen J, Goadsby P. Oxford, UK: Oxford University Press; 1999:23-26.
10. Granella F: Case-control study on the epidemiology of cluster headache. In Cluster Headache and Related Conditions. Edited by Olesen J, Goadsby P. Oxford, UK: Oxford University Press; 1999:37-41.
11. Torelli P, Cologno D, Manzone GC: Gender ratio in cluster headache. In Cluster Headache and Related Conditions. Edited by Olesen J, Goadsby P. Oxford, UK: Oxford University Press; 1999:48-52.
12. Graham J, Rogado AZ: Some physical, physiological and psychological characteristics of patients with cluster headaches. In Background to Migraines. Third Migraine Symposium, Migraine Trust. London: William Heinemann; 1969:38-52.
13. Matharu MS, Cohen AP, McGonigle DJ, et al.: Posterior hypothalamic and brainstem activation in hemicrania continua. Headache 2004, 44:747-761.
14. Pringsheim T: Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function. Can J Neurol Sci 2002, 29:33-40.
15. Stillman M: Testosterone replacement therapy for treatment of refractory cluster headache. Headache 2006, 46:925-933.
16. Stewart P: The adrenal cortex. In Williams Textbook of Endocrinology, edn 10. Edited by Larsen R. Philadelphia: Saunders; 2003:501-505.
17. May A, Bahra, A, Buchelk C, et al.: PET and MRA findings in cluster headache and MRA in experimental pain. Neurology 2000, 55:1328-1335.
18. Bussone G, Leone M, D'Amico D, et al.: Endocrinology of cluster headache. In Cluster Headache and Related Conditions. Edited by Olesen J. Goadsby P. Oxford, UK: Oxford University Press; 1999:179-185.
19. Leone M, Bussone G: A review of hormonal findings in cluster headache. Evidence for hypothalamic involvement. Cephalalgia 1993, 13:309-317.
20. Sjaastad O, Salvesen R, Antonacci F: Headache research strategy. Cephalalgia 1987, 7:1-6.
21. Polleri A: Sex steroids and cluster headaches: hypotheses. Cephalalgia 1990, 10:183-187.
22. Luboshitzky R, Lavi S, Lavie P: The association between melatonin and sleep stages in normal adults and hypogonadal men. Sleep 1999, 22:867-874.
23. Luboshitzky R, Herer P, Levi M, et al.: Relationship between rapid eye movement sleep and testosterone secretion in normal men. J Androl 1999, 20:731-737.
24. Luboshitzky R, Zabari Z, Shen-Orr Z, et al.: Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab 2001, 86:1134-1139.
25. Holland P, Goadsby PJ: The hypothalamic orexinergic system: pain and primary headaches. Headache 2007, 47:951-962.
26. Kudrow L: Plasma testosterone levels in cluster headache: preliminary results. Headache 1976, 16:28-31.
27. Nelson R: Testosterone levels in cluster and non-cluster migrainous headache patients. Headache 1978, 18:265-267.
28. Romiti A, Martelletti P, Gallo MF, Giacovazzo M: Low plasma testosterone levels in cluster headache. Cephalalgia 1983, 3:41-44.
29. Murialdo G, Fanciullacci M, Nicolodi M, et al.: Cluster headache in the male: sex steroid pattern and gonadotropic response to luteinizing hormone releasing hormone. Cephalalgia 1989, 9:91-98.
30. Facchinetti F, Nappi G, Cicolli C, et al.: Reduced testosterone levels in duster headache: a stress-related phenomenon? Cephalalgia 1986, 6:29-34.
31. Strittmatter M, Hamann GF, Grauer M, et al.: Altered activity of the sympathetic nervous system and changes in the balance of hypophyseal, pituitary and adrenal hormones in patients with cluster headache. Neuroreport 1996, 7:1229-1234.
32. McCann SM, Haens G, Mastronardi C, et al.: Role of nitric oxide (NO) in control of LHRH release that mediates gonadotropin release and sexual behavior. Curr Pharm Des 2003, 9:381-390.
33. Rettori V, Belova N, Dees WL, et al.: Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro. Proc Natl Acad Sci U S A 1993, 90:10130-10134
34. Waldenlind E, Bussone G: Biochemistry, circannual and circadian rhythms, endocrinology, and immunology of cluster headaches. In The Headaches, edn 3. Edited by Olesen J, Goadsby PJ, Ramadan NM, et al.: Philadelphia: Lippincott Williams & Wilkins; 2005:759-762.
35. Chazot G, Claustrat B, Brun J, et al.: A chronobiological study of melatonin, cortisol, growth hormone, and prolactin secretion in cluster headache. Cephalalgia 1984, 4:213-220.
36. Waldenlind E, Gustafsson SA, Ekbom K, Wetterberg L: Circadian secretion of cortisol and melatonin in cluster headache during active cluster periods and remission. J Neurol Neurosurg Psychiatry 1987, 50:207-213.
37. Waldenlind E, Ekbom K, Wetterberg L, et al.: Lowered circannual urinary melatonin concentrations in episodic cluster headache. Cephalalgia 1994, 14:199-204.
38. Frediani F, Amperti E, Leone M, et al.: Cluster headache patients' responses to dexamethasone suppression test. Headache 1988, 28:130-132.
39. Sandrini G, Ward TN: Acute treatment of cluster headache. In The Headaches, edn 3. Edited by Olesen J, Goadsby PJ, Ramadan NM, et al.: Philadelphia: Lippincott Williams & Wilkins; 2005:803-807.
40. Kudrow L: Cluster Headache. Mechanism and Management. Oxford, UK: Oxford University Press; 1980.
41. Couch JR, Ziegler DK: Prednisone therapy for cluster headache. Headache 1978, 18:219-221.
42. Mir P, Alberca R, Navarro A, et al.: Prophylactic treatment of episodic cluster headache with intravenous bolus of methylprednisolone. Neurol Sci 2003, 24:318-321.
43. Antonacci F, Costa A, Candeloro E, et al.: Single high-dose steroid treatment in episodic cluster headache. Cephalalgia 2005, 25:290-295.
44. Ambrosini A, Vandanheede M, Rossi P, et al.: Suboccipital (greater occipital nerve) injection with long-acting steroids in cluster headache: a double-blind, placebo-controlled study. Pain 2005, 118:92-96.
45. Shields KG, Levy MJ, Goadsby PJ: Alopecia and cutaneous atrophy after greater occipital nerve infiltration with corticosteroids. Neurology 2004, 63:2193-2194.
46. Klimek A: The use of testosterone in the treatment of cluster headache. Eur Neurol 1985, 24:53-56.
47. Griffin JE, Wilson JD: Disorders of the testes and the male reproductive tract. In Williams Textbook of Endocrinology, edn 10. Edited by Larsen W. Philadelphia: Saunders; 2003:726-751.
48. Santen RJ: Is aromatization of testosterone to estradiol required for inhibition of luteinizing hormone secretion in men? J Clin Invest 1975, 56:1555-1563.
49. Winters SJ, Troen P: Evidence for a role of endogenous estrogen in the hypothalamic control of gonadotropin secretion in men. J Clin Endocrinol Metab 1985, 61:842-845.
50. Nicolodi M, Sicuteri F, Poggioni M: Hypothalamic modulation of nociception and reproduction in cluster headache. I. Therapeutic trials of leuprolide. Cephalalgia 1993, 13:253-257.