Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo

Journal of Physiology and Pharmacology

Volumn 59, Issue 1, 2008, Pages 77-83

  Corpeleijn, E ^a   Pelsers, M M A L ^a   Soenen, S ^a   Mensink, M ^a   Bouwman, F G ^a   Kooi, M E ^b   Saris, W H M ^a   Glatz, J F C ^c   Blaak, E E ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

FAT CD36; Impaired glucose tolerance; Insulin action; Lipid metabolism; Obesity; Skeletal muscle

Indexed keywords

CD36 ANTIGEN; FATTY ACID TRANSPORTER; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID TRANSPORT; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; LIPID STORAGE; MALE; OBESITY; PROTEIN CONTENT; PROTEIN EXPRESSION; SKELETAL MUSCLE; UPREGULATION; VASTUS LATERALIS MUSCLE;

ANTIGENS, CD36; CYTOSOL; FATTY ACID-BINDING PROTEINS; FATTY ACIDS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OBESITY; TRIGLYCERIDES; UP-REGULATION;

EID: 42049116309     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase c, and ikappab-alpha. Diabetes 2002; 51: 2005-2011.
2. Bachmann OP, Dahl DB, Brechtel K, et al. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 2001; 50: 2579-2584.
3. Jensen MD. Fatty acid oxidation in human skeletal muscle. J Clin Invest 2002; 110: 1607-1609.
4. van Loon LJ, Goodpaster BH. Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. Pflugers Arch 2006; 451: 606-616.
5. Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: A reexamination. Diabetes 2000; 49: 677-683.
6. Blaak EE, van Aggel-Leijssen DP, Wagenmakers AJ, Saris WH, van Baak MA. Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. Diabetes 2000; 49: 2102-2107.
7. Mensink M, Blaak EE, van Baak MA, Wagenmakers AJ, Saris WH. Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes. Diabetes 2001; 50: 2548-2554.
8. Turpeinen AK, Takala TO, Nuutila P, et al. Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: Studies with pet and 14(r,s)-[18f]fluoro-6-thia-heptadecanoic acid. Diabetes 1999; 48: 1245-1250.
9. Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002; 45: 1201-1210.
10. Ravikumar B, Carey PE, Snaar JE, et al. Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes. Am J Physiol Endocrinol Metab 2005; 288: E789-797.
11. Febbraio M, Abumrad NA, Hajjar DP, et al. A null mutation in murine cd36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 1999; 274: 19055-19062.
12. Glatz JF, Bonen A, Luiken JJ. Exercise and insulin increase muscle fatty acid uptake by recruiting putative fatty acid transporters to the sarcolemma. Curr Opin Clin Nutr Metab Care 2002; 5: 365-370.
13. Chabowski A, Coort SL, Calles-Escandon J, et al. Insulin stimulates fatty acid transport by regulating expression of fat/cd36 but not fabppm. Am J Physiol Endocrinol Metab 2004; 287: E781-789.
14. Wodzig KW, Pelsers MM, van der Vusse GJ, Roos W, Glatz JF. One-step enzyme-linked immunosorbent assay (elisa) for plasma fatty acid-binding protein. Ann Clin Biochem 1997; 34 (Pt 3): 263-268.
15. Pelsers MM, Lutgerink JT, Nieuwenhoven FA, et al. A sensitive immunoassay for rat fatty acid translocase (cd36) using phage antibodies selected on cell transfectants: Abundant presence of fatty acid translocase/cd36 in cardiac and red skeletal muscle and up-regulation in diabetes. Biochem J 1999; 337 (Pt 3): 407-414.
16. Koopman R, Schaart G, Hesselink MK. Optimisation of oil red o staining permits combination with immunofluorescence and automated quantification of lipids. Histochem Cell Biol 2001; 116: 63-68.
17. Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. Increased malonyl-coa levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 2006; 55: 2277-2285.
18. Binas B, Danneberg H, McWhir J, Mullins L, Clark AJ. Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization. FASEB J 1999; 13: 805-812.
19. Luiken JJ, Koonen DP, Coumans WA, et al. Long-chain fatty acid uptake by skeletal muscle is impaired in homozygous, but not heterozygous, heart-type-fabp null mice. Lipids 2003; 38: 491-496.
20. Bonen A, Parolin ML, Steinberg GR, et al. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal fat/cd36. FASEB J 2004; 18: 1144-1146.