Dragging along: The glycocalyx and vascular endothelial cell mechanotransduction

Circulation Research

Volumn 102, Issue 7, 2008, Pages 747-748

  Barakat, Abdul I ^a  

^a University of California   (United States)

Author keywords

Glycocalyx; Mechanotransduction

Indexed keywords

CELL CULTURE; EDITORIAL; ENDOTHELIUM CELL; FUNDING; GEOMETRY; GLYCOCALYX; HUMAN; HYDRODYNAMICS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LINEAR REGRESSION ANALYSIS; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD FLOW VELOCITY; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; GLYCOCALYX; HUMANS; HYALURONIC ACID; LINEAR MODELS; MECHANOTRANSDUCTION, CELLULAR; REGIONAL BLOOD FLOW; RHEOLOGY;

EID: 42049114057     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.174839     Document Type: Editorial

References (24)

1. Tarbell JM, Pahakis MY. Mechanotransduction and the glycocalyx. J Intern Med. 2006;259:339-350.
2. Weinbaum S, Tarbell JM, Damiano ER. The structure and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng. 2007;9:121-167.
3. Noble MI, Drake-Holland AJ, Vink H. Hypothesis: arterial glycocalyx dysfunction is the first step in the atherothrombotic process. QJM. In press.
4. van den Berg B, Vink H. Glycocalyx perturbation: cause or consequence of damage to the vasculature? Am J Physiol. 2006;290:H2174-H2175.
5. van den Berg BM, Spaan JA, Rolf TM, Vink H. Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation. Am J Physiol. 2006;290:H915-H920.
6. Florian JA, Kosky JR, Ainslie K, Pang Z, Dull RO, Tarbell JM. Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circ Res. 2003;93:e136-e142.
7. Hecker M, Mulsch A, Bassenge E, Busse R. Vasoconstriction and increased flow: two principal mechanisms of shear stress-dependent endothelial autacoid release. Am J Physiol. 1993;265:H828-H833.
8. Mochizuki S, Vink H, Hiramatsu O, Kajita T, Shigeto F, Spaan JA, Kajiya F. Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release. Am J Physiol. 2003;285:H722-H726.
9. Pahakis MY, Kosky JR, Dull RO, Tarbell JM. The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress. Biochem Biophys Res Com. 2007;355:228-233.
10. Pohl U, Herlan K, Huang A, Bassenge E. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol. 1991;261:H2016-H2023.
11. Thi MM, Tarbell JM, Weinbaum S, Spray DC. The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: a "bumper-car" model. Proc Natl Acad Sci U S A. 2004;101:16483-16488.
12. Yao Y, Rabodzey A, Dewey CF Jr. Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stress. Am J Physiol. 2007;293:H1023-H1030.
13. Potter DR, Damiano ER. The hydrodynamically relevant endothelial cell glycocalyx observed in vivo is absent in vitro. Circ Res. 2008;102:770-776.
14. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev. 1995;75:519-560.
15. Barakat AI, Leaver EV, Pappone PA, Davies PF. A flow-activated chloride-selective membrane current in vascular endothelial cells. Circ Res. 1999;85:820-828.
16. Gautam M, Shen Y, Thirkill TL, Douglas GC, Barakat AI. Flow-activated chloride channels in vascular endothelium. Shear stress sensitivity, desensitization dynamics, and physiological implications. J Biol Chem. 2006;281:36492-36500.
17. Lieu DK, Pappone PA, Barakat AI. Differential membrane potential and ion current responses to different types of shear stress in vascular endothelial cells. Am J Physiol. 2004;286:C1367-C1375.
18. Shyy JY, Chien S. Role of integrins in endothelial mechanosensing of shear stress. Circ Res. 2002;91:769-775.
19. Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature. 2005;437:426-431.
20. Chachisvilis M, Zhang YL, Frangos JA. G protein-coupled receptors sense fluid shear stress in endothelial cells. Proc Natl Acad Sci U S A. 2006;103:15463-15468.
21. Gudi S, Nolan JP, Frangos JA. Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition. Proc Natl Acad Sci U S A. 1998;95:2515-2519.
22. Dull RO, Davies PF. Flow modulation of agonist (ATP)-response (Ca2+) coupling in vascular endothelial cells. Am J Physiol. 1991;261:H149-H154.
23. Adamson RH, Clough G. Plasma proteins modify the endothelial cell glycocalyx of frog mesenteric microvessels. J Physiol. 1992;445:473-486.
24. Pries AR, Secomb TW, Gaehtgens P. The endothelial surface layer. Pflug Arch. 2000;440:653-666.