Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions

Cell Cycle

Volumn 7, Issue 6, 2008, Pages 750-753

  Saikkonen, Brenda ^a   Pareek, Tej Kumar ^b   Agarwal, Nitin ^c   Molinolo, Alfredo ^a   Kriete, Martin ^a   Kulkarni, Ashok B ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cdk5; Nociception; Psoriasis; Skin; Wound healing

Indexed keywords

BACITRACIN; COTRIMOXAZOLE; CYCLIN DEPENDENT KINASE 5; DEXAMETHASONE; HYDROCORTISONE; NEOMYCIN; POLYMYXIN; POVIDONE IODINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATYPICAL SKIN LESION; CONTROLLED STUDY; GENE DELETION; HYPOALGESIA; MOUSE; NONHUMAN; PYODERMA GANGRENOSUM; SENSORY DYSFUNCTION; SENSORY NERVE CELL; SKIN DEFECT;

MUS;

EID: 42049105534     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.6.5494     Document Type: Article

References (6)

1. Pareek TK, Keller J, Kesavapany S, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB. Cyclin-dependent kinase 5 activity regulates pain signaling. Proceedings of the National Academy of Sciences of the United States of America 2006; 103:791-6.
2. Pareek TK, Kulkarni AB. Cdk5: a new player in pain signaling. Cell cycle 2006; 5:585-8.
3. Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB. Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proceedings of the National Academy of Sciences of the United States of America 2007; 104:660-5.
4. Kastenmayer RJ, Fain MA, Perdue KA. A retrospective study of idiopathic ulcerative dermatitis in mice with a C57BL/6 background. J Am Assoc Lab Anim Sci 2006; 45:8-12.
5. Lawson GW, Sato A, Fairbanks LA, Lawson PT. Vitamin E as a treatment for ulcerative dermatitis in C57BL/6 mice and strains with a C57BL/6 background. Contemporary topics in laboratory animal science American Association for Laboratory Animal Science 2005; 44:18-21.
6. Nakano N, Nakao A, Ishidoh K, Tsuboi R, Kominami E, Okumura K, Ogawa H. CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. British Journal of Dermatology 2005; 153:37-45.