Leptin protection of salivary gland acinar cells against ethanol cytotoxicity involves Src kinase-mediated parallel activation of prostaglandin and constitutive nitric oxide synthase pathways

Inflammopharmacology

Volumn 16, Issue 2, 2008, Pages 76-82

  Slomiany, B L ^a   Slomiany, A ^a  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

CNOS; CPLA2; Ethanol cytotoxicity; Leptin; NO; PGE2; Salivary gland; Src activation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ALCOHOL; ARACHIDONIC ACID; CYTOKINE; INDOMETACIN; LEPTIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN TYROSINE KINASE; WORTMANNIN;

ACINAR CELL; ADIPOCYTE; ALCOHOL ABUSE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; FUNCTIONAL PROTEOMICS; IMMUNOMODULATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN FUNCTION; RAT; SALIVARY GLAND; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; CELLS, CULTURED; DRUG ANTAGONISM; ENZYME ACTIVATION; ETHANOL; LEPTIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PROSTAGLANDINS; RATS; SALIVARY GLANDS; SRC-FAMILY KINASES; UP-REGULATION;

EID: 42049101201     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-007-1650-9     Document Type: Article

References (37)

1. Anter, E., Thomas, S. R., Schulz, E.,, et al. (2004). Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols, J. Biol. Chem. 279, 46637-43.
2. Brooks, P. J. (1997). DNA damage, DNA repair, and alcohol toxicity - a review, Alcohol. Clin. Exp. Res, 21, 1073-82.
3. Brzozowski, T., Konturek, P. C., Konturek, S. J., et al. (1999). Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide, Eur. J. Pharmacol. 374, 263-76.
4. 2+- dependent death, J. Biol. Chem. 281, 6106-16.
5. Dutta, S. K., Dukehart, M., Narang, A., et al. (1989). Functional and structural changes in parotid glands in alcoholic cirrhotic patients, Gastroenterology, 96, 510-8.
6. Faggioni, R., Feingold, K. R. and Grunfeld, C. (2001). Leptin regulation of the immune responses and immunodeficiency of malnutrition, FASEB J. 15, 2565-71.
7. Fruhbeck, G. (2006). Intracellular signaling pathways activated by leptin, Biochem. J. 393, 7-20.
8. Fruhbeck, G. and Gomez-Ambrosi, J. (2001). Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide, Cell Signal. 13, 827-33.
9. Graham, G. J. and Rennie, J. S. (1987). Biochemical abnormalities of rat lingual epithelium following chronic alcohol intake, Arch. Oral Biol. 32, 1-3.
10. Groschl, M., Rauch, M., Wagner, R., et al. (2001). Identification of leptin in human saliva, J. Clin. Endocrinol. Metab. 86, 5234-9.
11. Haynes, M.P., Li, L., Sinha, D., et al. (2003). Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen, J. Biol. Chem. 278, 2118-23.
12. Hirabayshi, T. and Shimizu, T. (2000). Localization and regulation of cytosolic phospholipase A2, Biochim. Biophys. Acta 1488, 124-38.
13. Kim, G. S., Hong, J. S., Kim, S. W., et al. (2003). Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells, J. Biol. Chem. 278, 21920-9.
14. Konturek, P. C., Brzozowski, T., Sulekova, Z., et al. (1999). Enhanced expression of leptin following acute gastric injury in rat, J. Physiol. Pharmacol. 50, 587-95.
15. Konturek, P. C., Brzozowski, T., Sulekova, Z., et al. (2001). Role of leptin in ulcer healing, Eur. J. Pharmacol. 414, 87-97.
16. Loffreda, S., Yang, S. Q., Lin, H. Z., et al. 1998). Leptin regulates proinflammatory immune responses, FASEB J. 12, 57-65.
17. Lorenz, M., Wessler, S., Follmann, E., et al. (2004). A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phopsphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation, J. Biol. Chem. 279, 6190-5.
18. Mastronardi, C. A., Yu, W. H. and McCann, S. M. (2002). Resting and circadian release of nitric oxide is controlled by leptin in male rats, Proc. Natl. Acad. Sci. USA 99, 5721-6.
19. Nishi, Y., Isomoto, S., Uotani, S., et al. (2005). Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection, World J. Gastroenterol. 11, 695-9.
20. Proctor, G. and Shori, D. K. (1995). The effects of ethanol on salivary glands, in: Alcohol and Gastrointestinal Tract, Preedy, V. R. and Watson, R. R. (Eds.), pp. 111-122, CRC Press, Boca Raton, FL.
21. Qi, H. Y., Shelhamer. J. H. (2005). Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages, J. Biol. Chem. 280, 38969-75.
22. 2 as defined by gene knockout, Biochim. Biophys. Acta 1488, 139-148.
23. Scott, J., Burns, J. and Flower, E. A. (1988). Histological analysis of parotid and submandibular glands in chronic alcohol abuse: A necropsy study, J. Clin. Phathol. 41, 837-40.
24. 1 macrophages using GFP/REP constructs, Biochim. Biophys. Acta 1735, 119-29.
25. Slomiany, B. L., Piotrowski, J. and Slomiany, A. (1997). Chronic alcohol ingestion enhances tumor necrosis factor-α expression and salivary gland apoptosis, Alcohol. Clin. Exp. Res. 21, 1530-3.
26. Slomiany, B. L., Piotrowski, J. and Slomiany, A. (1998). Alterations in buccal mucosal endothelin-1 and nitric oxide synthase with chronic alcohol ingestion, Biochem. Mol. Biol. Int. 45, 681-8.
27. Slomiany, B. L. and Slomiany, A. (2003). Leptin suppresses Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis, Biochem. Biophys. Res. Commun. 312, 1099-103.
28. Slomiany, B. L. and Slomiany, A. (2004). Src kinase-dependent epidermal growth factor receptor transactivation in PPARγ ligand-induced suppression of Porphyromonas gingivalis interference with salivary mucin synthesis, IUBMB Life 56, 153-9.
29. Slomiany, B.L. and Slomiany, A. (2005). Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair, J. Physiol. Pharmacol. 56, 531-541.
30. 2 activation on salivary mucin synthesis via ERK-signal transduction, Inflammopharmacol. 14, 250-5.
31. Slomiany, B. L. and Slomiany, A. (2007). Alterations by indomethacin in proinflammatory consequences of salivary gland cytosolic phospholipase A2 activation by Porphyromonas gingivalis: role of leptin, J. Appl. Res. 7, 127-36.
32. Sobhani, I., Bado, A., Visuzaine, C., et al. (2000). Leptin secretion and leptin receptor in the human stomach, Gut 47, 178-83.
33. Takahashi, N., Waelput, W. and Guisez, Y. (1999). Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor, J. Exp. Med. 189, 207-12.
34. Vecchione, C., Maffei, A., Collela, S., et al. (2002). Leptin effect on endothelial nitric oxide synthase is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway, Diabetes 51, 168-73.
35. Wanger, D. A., Glogowski, J., Skipper, P. L., et al. (1982). Analysis of nitrate, nitrite and [15N]nitrate in biological fluids, Anal. Biochem. 126, 131-8.
36. Wu-Wang, C. Y., Wang, S. L., Lim, C., et al. (1991). Impairment by ethanol of prostaglandin production in rat salivary glands, Archs Oral Biol. 36, 9-13.
37. Yamada, M., Watanabe, M., Mue, S., et al. (1996). Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2, J. Pharmacol. Exp. Ther. 277, 1607-14.