Cerebellar pathology in transgenic mice expressing the pseudorabies virus immediate-early protein IE180

European Journal of Neuroscience

Volumn 27, Issue 8, 2008, Pages 2115-2132

  Tomioka, Yukiko ^a   Miyazaki, Taisuke ^b   Taharaguchi, Satoshi ^a,c   Yoshino, Saori ^d   Morimatsu, Masami ^a   Uede, Toshimitsu ^a   Ono, Etsuro ^a,e,f   Watanabe, Masahiko ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d Gene Techno Science   (Japan)

^e TOTTORI UNIVERSITY   (Japan)

^f KYUSHU UNIVERSITY   (Japan)

Author keywords

Cerebellum; Cytotoxicity; Immediate early protein; Pseudorabies virus; Transgenic mouse

Indexed keywords

IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN IE180; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM DISEASE; CONTROLLED STUDY; DENDRITE; GRANULE CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTERNEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDORABIES; PSEUDORABIES HERPETOVIRUS; PURKINJE CELL; SYNAPTOGENESIS; TRANSGENIC MOUSE; VIRUS CELL INTERACTION;

ANIMALS; APOPTOSIS; CEREBELLUM; GAIT ATAXIA; HERPESVIRUS 1, SUID; IMMEDIATE-EARLY PROTEINS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; PHENOTYPE; TRANSGENES;

EID: 42049098626     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06174.x     Document Type: Article

References (50)

1. Altman, J. (1972) Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layer. J. Comp. Neurol., 145, 465 514.
2. Altman, J. Anderson, W.J. (1972) Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of all microneurons with prolonged x-irradiation started at birth. J. Comp. Neurol., 146, 355 406.
3. Altman, J. Anderson, W.J. (1973) Experimental reorganization of the cerebellar cortex. II. Effects of elimination of most microneurons with prolonged x-irradiation started at four days. J. Comp. Neurol., 149, 123 152.
4. Bartolome, J.V., Schweitzer, L., Slotkin, T.A. Nadler, J.V. (1985) Impaired development of cerebellar cortex in rats treated postnatally with α-difluoromethylornithine. Neuroscience, 15, 203 213.
5. Cheung, A.K. (1989) DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus. Nucl. Acids Res., 17, 4637 4646.
6. Chlan, C.A., Coulter, C. Feldman, L.T. (1987) Binding of the pseudorabies virus immediate-early protein to single-stranded DNA. J. Virol., 61, 1855 1860.
7. Cromlish, W.A., Abmayr, S.M., Workman, J.L., Horikoshi, M. Roeder, R.G. (1989) Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters. J. Virol., 63, 1869 1876.
8. Cui, W., Allen, N.D., Skynner, M., Gusterson, B. Clark, A.J. (2001) Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia, 34, 272 282.
9. Delaney, C.L., Brenner, M. Messing, A. (1996) Conditional ablation of cerebellar astrocytes in postnatal transgenic mice. J. Neurosci., 16, 6908 6918.
10. Fukudome, Y., Ohno-Shosaku, T., Matsui, M., Omori, Y., Fukaya, M., Tsubokawa, H., Taketo, M.M., Watanabe, M., Manabe, T. Kano, M. (2004) Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur. J. Neurosci., 19, 2682 2692.
11. Furuya, S., Tabata, T., Mitoma, J., Yamada, K., Yamasaki, M., Makino, A., Yamamoto, T., Watanabe, M., Kano, M. Hirabayashi, Y. (2000) L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. Proc. Natl Acad. Sci. U.S.A., 97, 11 528 11 533.
12. Green, M.R., Treisman, R. Maniatis, T. (1983) Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell, 35, 137 148.
13. Hobbs, W.E., Brough, D.E., Kovesdi, I. Deluca, N.A. (2001) Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival. J. Virol., 75, 3391 3403.
14. Hogan, B., Beddington, R., Constantini, F. Lacy, E. (1994) Isolating high-molecular-weight DNA from mouse tails. In Hogan, B., Beddington, R., Constantini, F. Lacy, E. (Eds), Manipulating the Mouse Embryo. A Laboratory Manual, 2nd Edn. Cold Spring. Harbor Laboratory Press, New York, pp. 296 298.
15. Ihara, S., Feldman, L., Watanabe, S. Ben-Porat, T. (1983) Characterization of the immediate-early functions of pseudorabies virus. Virology, 131, 437 454.
16. Iijima, T., Miura, E., Matsuda, K., Kamekawa, Y., Watanabe, M. Yuzaki, M. (2007) Characterization of a transneuronal cytokine family Cbln - regulation of secretion by heteromeric assembly. Eur. J. Neurosci., 25, 1049 1057.
17. Inman, M., Zhang, Y., Geiser, V. Jones, C. (2001) The zinc ring finger in the bICP0 protein encoded by bovine herpesvirus-1 mediates toxicity and activates productive infection. J. Gen. Virol., 82, 483 492.
18. Jones, B.J. Roberts, D.J. (1968) A rotarod suitable for quantitative measurements of motor incoordination in naive mice. Ninny. Schmiedebergs Arch. Exp. Pathol. Pharmakol., 259, 211.
19. Kritas, S.K. Pensaert, M.B. (1994) Role of gp63 and gIII of Aujeszky's disease virus in the invasion of the olfactory nervous pathway in neonatal pigs. Acta Vet. Hung., 42, 309 316.
20. Kritas, S.K., Pensaert, M.B. Mettenleiter, T.C. (1994) Invasion and spread of single glycoprotein deleted mutants of Aujeszky's disease virus (ADV) in the trigeminal nervous pathway of pigs after intranasal inoculation. Vet. Microbiol., 40, 323 334.
21. Martin, K.J., Lillie, J.C. Green, M.R. (1990) Transcriptional activation by the pseudorabies virus immediate early protein. Genes Dev., 4, 2376 2382.
22. Miura, E., Fukaya, M., Sato, T., Sugihara, K., Asano, M., Yoshioka, K. Watanabe, M. (2006) Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J. Neurochem., 97, 1431 1446.
23. Miyazaki, T., Fukaya, M., Shimizu, H. Watanabe, M. (2003) Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum. Eur. J. Neurosci., 17, 2563 2572.
24. Nakagawa, S., Watanabe, M., Isobe, T., Kondo, H. Inoue, Y. (1998) Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells. J. Comp. Neurol., 395, 112 120.
25. Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M. Watanabe, M. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1 alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci., 20, 2929 2944.
26. Pang, Z., Zuo, J. Morgan, J.I. (2000) Cbln3, a novel member of the precerebellin family that binds specifically to Cbln1. J. Neurosci., 20, 6333 6339.
27. Rakic, P. (1971) Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. J. Comp. Neurol., 141, 283 312.
28. Ramón y Cajal, S. (1911) Histologie du Système Nerveux de l'Homme et des Vertébrés. Tome 2. Maloine, Paris. Reprinted by Consejo Superior de Investigaciones Cientificas, Madrid, 1955.
29. Roizman, B. Knipe, D.M. (2001) Herpes simplex viruses and their replication. In Knipe, D.M. Howley, P.M. (Eds), Fields Virology, 4th Edn. Lippincott Williams & Wilkins, Philadelphia, pp. 2399 2459.
30. Sakai, K., Shimizu, H., Koike, T., Furuya, S. Watanabe, M. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J. Neurosci., 23, 550 560.
31. Schreiber, E., Matthias, P., Muller, M.M. Schaffner, W. (1989) Rapid detection of octameric binding protein with 'mini-extracts', prepared from a small number of cells. Nucl. Acid Res., 17, 6419.
32. Shockett, P., Difilippantonio, M., Hellman, N. Schatz, D.G. (1995) A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc. Natl Acad. Sci. U.S.A., 92, 6522 6526.
33. Sotelo, C., Alvarado-Mallart, R.M., Frain, M. Vernet, M. (1994) Molecular plasticity of adult Bergmann fibers is associated with radial migration of grafted Purkinje cells. J. Neurosci., 14, 124 133.
34. Spacek, J. (1985) Three-dimensional analysis of dendritic spines. III. Glial sheath. Anat. Embryol. (Berl.), 171, 245 252.
35. Summers, B.A., Cummings, J.F. de Lahunta, A. (1995) Inflammatory disease of the central nervous system. In Veterinary Neuropathology. Mosby-Year Book, Inc., St. Louis, pp. 95 188.
36. Taharaguchi, S., Inoue, H., Ono, E., Kida, H., Yamada, S. Shimizu, Y. (1994) Mapping of transcriptional regulatory domains of pseudorabies virus immediate-early protein. Arch. Virol., 137, 289 302.
37. Taharaguchi, S., Ono, E., Yamada, S., Shimizu, Y. Kida, H. (1995) Mapping of a functional region conferring nuclear localization of pseudorabies virus immediate-early protein. Arch. Virol., 140, 1737 1746.
38. Taharaguchi, S., Kon, Y., Yoshino, S. Ono, E. (2003) Impaired development of the cerebellum in transgenic mice expressing the immediate-early protein IE180 of pseudorabies virus. Virology, 307, 243 254.
39. Towbin, H., Staehelin, T. Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. U.S.A., 76, 4350 4354.
40. Tsurushima, H., Yuasa, S., Kawamura, K. Nose, T. (1993) Expression of tenascin and BDNF during the migration and differentiation of grafted Purkinje and granule cells in the adult rat cerebellum. Neurosci. Res., 18, 109 120.
41. Van Oirschot, J.T., Gielkens, A.L., Moormann, R.J. Berns, A.J. (1990) Marker vaccines, virus protein-specific antibody assays and the control of Aujeszky's disease. Vet. Microbiol., 23, 85 101.
42. Wong, M.L., Ho, T.Y., Huang, J.H., Hsiang, C.Y. Chang, T.J. (1997) Stimulation of type I DNA topoisomerase gene expression by pseudorabies virus. Arc. Virol., 142, 2099 2105.
43. Wu, L. Berk, A.J. (1988) Transcriptional activation by the pseudorabies virus immediate early protein requires the TATA box element in the adenovirus 2 E1B promoter. Virology, 167, 318 322.
44. Wu, C.L. Wilcox, K.W. (1991) The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters. J. Virol., 65, 1149 1159.
45. Yamada, K. Watanabe, M. (2002) Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells. Anat. Sci. Int., 77, 94 108.
46. Yamada, K., Fukaya, M., Shibata, T., Kurihara, H., Tanaka, K., Inoue, Y. Watanabe, M. (2000) Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells. J. Comp. Neurol., 418, 106 120.
47. Yamasaki, M., Yamada, K., Furuya, S., Mitoma, J., Hirabayashi, Y. Watanabe, M. (2001) 3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain. J. Neurosci., 21, 7691 7704.
48. Yuan, R., Bohan, C., Shiao, F.C., Robinson, R., Kaplan, H.J. Srinivasan, A. (1989) Activation of HIV LTR-directed expression: analysis with pseudorabies virus immediate early gene. Virology, 172, 92 99.
49. Yuasa, S. (1996) Bergmann glial development in the mouse cerebellum as revealed by tenascin expression. Anat. Embryol. (Berl.), 194, 223 234.
50. Yuasa, S., Kawamura, K., Ono, K., Yamakuni, T. Takahashi, Y. (1991) Development and migration of Purkinje cells in the mouse cerebellar primordium. Anat. Embryol. (Berl.), 184, 195 212.