Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents

Medical Science Monitor

Volumn 14, Issue 4, 2008, Pages

  Zhang, Qingyou ^a   Jin, Hongfang ^a   Wang, Li ^a   Chen, Jianjun ^a   Tang, Chaoshu ^a   Du, Junbao ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Children and adolescents; Metoprolol; Syncope

Indexed keywords

METOPROLOL;

ADOLESCENT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFICACY; FEMALE; FOLLOW UP; HEART RATE; HUMAN; KAPLAN MEIER METHOD; LOG RANK TEST; MALE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SCHOOL CHILD; SYNCOPE; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME;

ADOLESCENT; CHILD; FEMALE; HUMANS; MALE; METOPROLOL; RECURRENCE; SYNCOPE, VASOVAGAL;

EID: 42049097683     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Wieling W, Ganzeboom KS, Saul JP: Reflex syncope in children and adolescents. Heart, 2004; 90(9): 1094-99
2. Benditt DG, Ferguson DW, Grubb BP et al: Tilt table testing for assessing syncope (ACC Expert Consensus Document). J Am Coll Cardiol, 1996; 28: 263-75
3. Qingyou Z, Junbao D, Chaoshu T: The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope. J Pediatr, 2006; 149: 777-80
4. Massin MM: Neurocardiogenic syncope in children: current concepts in diagnosis and management. Pediatr Drugs, 2003; 5: 327-34
5. Biffi M, Boriani G, Sabbatani P et al: Malignant vasovagal syncopal syncope: a randomized trial of metoprolol and clonidine. Heart, 1997; 77: 268-72
6. Jhamb DK, Singh B, Sharda B et al: Comparative study of the efficacy of metoprolol and verapamil in patients with syncope and positive head-up tilt test response. Am Heart J, 1996; 132: 608-11
7. Sheldon R, Connolly S, Rose S et al: Prevention of syncope trial: A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope. Circulation, 2006; 113: 1164-70
8. Kim KH, Chao JG, Lee KO et al: Usefulness of physical maneuvers for prevention of vasovagal syncope. Circ J, 2005; 69: 1084-88
9. Krediet CP, Dijk N, Linzer M et al: Management of vasovagal syncope: Controlling or aborting faints by leg crossing and muscle tensing. Circulation, 2002; 106: 1684-89
10. Qingyou Z, Junbao D, Jianjun C, Wangzhen L: Association of clinical characteristics of children with unexplained syncope and the outcome of head-up tilt tests. Pediatr Cardiol, 2004; 25: 360-64
11. Strickberger SA, Benson DW, Biaggioni I et al: AHA/ACCF Scientific Statement on the evaluation of syncope: from the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research Interdisciplinary Working Group; and the American College of Cardiology Foundation: in collaboration with the Heart Rhythm Society: endorsed by the American Autonomic Society. Circulation, 2006; 113(2): 316-27
12. Salim MA, Di Sessa TG: Effectiveness of fludrocortisone and salt in preventing syncope recurrence in children: a double-blind, placebo-controlled, randomized trial. J Am Coll Cardiol, 2005; 45: 484-88
13. Brignole M, Alboni P, Benditt D et al: Guidelines on management (diagnosis and treatment) of syncope-update 2004. Eur Heart J, 2004; 25(22): 2054-72
14. Madrid AH, Ortega J, Rebollo JG et al: Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic population: a prospective, double-blind, randomized and placebo-controlled study. J Am Coll Cardiol, 2001; 37: 554-59
15. Natale A, Newby KH, Dhala A et al: Response to beta-blockers in patients with neurocardiogenic syncope: how to predict beneficial effects. J Cardiovasc Electrophysiol, 1996; 7: 1154-58
16. Leor J, Rotstein Z, Vered Z et al: Absence of tachycardia during tilt test predicts failure of beta-blocker therapy in patients with neurocardiogenic syncope. Am Heart J, 1994; 127: 1539-43
17. Almquist A, Goldenberg IF, Milstein S et al: Provocation of bradycardia and hypotension by isoproterenol and upright posture in patients with unexplained syncope. N Engl J Med, 1989; 320: 345-51
18. Sra JS, Murthy VS, Jazayeri MJ et al: Use of intravenous esmolol to predict efficacy of oral beta-adrenergic blocker therapy in patients with neurocardiogenic syncope. J Am Coll Cardiol, 1992; 19: 402-8
19. MÜller G, Deal BJ, Strasburger JF, Benson DW: Usefulness of metoprolol for unexplained syncope and positive response to tilt testing in young persons. Am J Cardiol, 1993; 71: 592-95
20. O'Marcaigh AS, MacLellan-Tobert SG, Porter CJ: Tilt-table testing and oral metoprolol therapy in young patients with unexplained syncope. Pediatrics, 1994; 93: 278-83
21. Scott WA, Pongiglione G, Bromberg B et al: Randomized comparison of atenolol and fludrocotisone acetate in the treatment of pediatric neurally mediated syncope. Am J Cardiol, 1995; 76: 400-2
22. Kouakam C, Vaksmann G, Pachy E et al: Long-term follow-up of children and adolescents with syncope: Predictor of syncope recurrence. Eur Heart J, 2001; 22: 1618-25
23. Levine MM: Neurally mediated syncope in children: Results of tilt testing, treatment, and long-term follow-up. Pediatr Cardiol, 1999; 20: 331-35
24. Dendi R, Goldstein D: Meta-analysis of nonselective verus beta-1 adrenoceptor-selective blockade in prevention of tilt-induced neurocardiogenic syncope. Am J Cardiol, 2002; 89: 1319-21