HIV vaccine research in Thailand: Lessons learned

Expert Review of Vaccines

Volumn 7, Issue 3, 2008, Pages 311-317

  Pitisuttithum, Punnee ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Clinical research; HIV vaccine; Lessons learned; Thailand

Indexed keywords

ANTIRETROVIRUS AGENT; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; RECOMBINANT CANARYPOX VECTOR VACCINE; RECOMBINANT GLYCOPROTEIN GP 120 VACCINE; SF2 GP 120 VACCINE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VCP 1521;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CELLULAR IMMUNITY; CLINICAL TRIAL; DEVELOPING COUNTRY; DRUG EFFICACY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; MEDICAL RESEARCH; PRIORITY JOURNAL; REVIEW; THAILAND;

AIDS VACCINES; ANIMALS; CLINICAL TRIALS AS TOPIC; HIV INFECTIONS; HIV-1; HUMANS; THAILAND;

EID: 42049092979     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.7.3.311     Document Type: Review

References (21)

1. Phanuphak P, Teeratakulpixarn S, Sarangbin S et al. International clinical trials of HIV vaccines: I. Phase I trial of an HIV-1 synthetic peptide vaccine in Bangkok, Thailand. Asian Pac. J. Allergy Immunol. 15(1), 41-48 (1997).
2. Migasena S, Suntharasamai P, Pitisuttithum P et al. AIDSVAX (MN) in Bangkok injecting drug users: a report on safety and immunogenicity, including macrophage-tropic virus neutralization. AIDS Res. Hum. Retroviruses 16(7), 655-663 (2000).
3. Nitayaphan S, Khamboonruang C, Sirisophana N et al. A Phase I/II trial of HIV SF2 gp120/MF59 vaccine in seronegative thais. AFRIMS-RIHES Vaccine Evaluation Group. Armed Forces Research Institute of Medical Sciences and the Research Institute for Health Sciences. Vaccine 18(15), 1448-1455 (2000).
4. Pitisuttithum P, Nitayaphan S, Thongcharoen P et al. Safety and immunogenicity of combinations of recombinant subtype E and B human immunodeficiency virus type 1 envelope glycoprotein 120 vaccines in healthy Thai adults. J. Infect. Dis. 188(2), 219-227 (2003).
5. Pitisuttithum P, Berman PW, Phonrat B et al. Phase I/II study of a candidate vaccine designed against the B and E subtypes of HIV-1. J. Acquir. Immune Defic. Syndr. 37(1), 1160-1165 (2004); erratum in J. Acquir. Immune Defic. Syndr. 37(5), 1669 (2004).
6. Wasi C, Sutthent R, Osmanov S. The AIDS epidemic in Thailand: molecular epidemiology of HIV in Thailand. In: HIV Vaccine Research and Development in Thailand. Pitisuttithum P, Francis DP, Esparza J, Thongcharoen P (Eds). Amarin Printing and Publishing Public Company, Bangkok, Thailand 31-50 (2006).
7. Khamboonruang C. Developing cohorts for Phase III trials of candidate HIV vaccines: Chiang Mai community cohort. In: HIV Vaccine Research and Development in Thailand. Pitisuttithum P, Francis DP, Esparza J, Thongcharoen P (Eds). Amarin Printing and Publishing Public Company, Bangkok, Thailand 221-238 (2006).
8. Vanichseni S, Kitayaporn D, Mastro TD. Developing cohorts for Phase III trials of candidate HIV vaccines: the Bangkok Metropolitan Administration (BMA) cohort of injecting drug users (IDUs). In: HIV Vaccine Research and Development in Thailand. Pitisuttithum P, Francis DP, Esparza J, Thongcharoen P (Eds). Amarin Printing and Publishing Public Company, Bangkok, Thailand 241-249 (2006).
9. Benenson MW. Developing cohorts for Phase III trials of candidate HIV vaccines: community cohorts in Rayong and Chon Buri. In: HIV Vaccine Research and Development in Thailand. Pitisuttithum P, Francis DP, Esparza J, Thongcharoen P (Eds). Amarin Printing and Publishing Public Company, Bangkok, Thailand 251-261 (2006).
10. Pitisuttithum P, Gilbert P, Gurwith M et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J. Infect. Dis. 194(12), 1661-1671 (2006).
11. van Griensvan F, Keawkungwal J, Tappero JW et al. Lack of increased HIV risk behavior among injection drug users participating in the AIDSVAX B/E HIV vaccine trial in Bangkok, Thailand. AIDS 18(2), 295-301 (2004).
12. Suntharasamai P, Martin M, Vanichseni S et al. Incarceration and the risk for HIV infection among injection drug users participating in an HIV vaccine trial in Bangkok, 1999-2003 (2008) (In press).
13. Pitisuttithum P, Choopanya K, Bussaratid V et al. Social harms in injecting drug users participating in the first Phase III HIV vaccine trial in Thailand. J. Med. Assoc. Thai. 90 (11), 2441-2448 (2007).
14. Suriyanon V, Gurunathan S, Thongcharoen P et al. Safety and tolerability of live recombinant ALVACHIV (vCP1521) priming with either gp160 or gp120 boosting in Thai seronegative. Presented at: 6th International Congress on AIDS in Asia and the Pacific. Melbourne, Australia, 5-10 October, 2001.
15. Nitayaphan S, Pitisuttithum P, Karnasuta C et al. Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults. J. Infect. Dis. 190(4), 702-706 (2004).
16. Rerks-Ngarm S, Chunsuttiwat S, Pitisuttithum P et al. Thai prime-boost HIV vaccine Phase III trial: update 2007. Presented at: AIDS Vaccine 2007. Seattle, WA, USA, 20-23 August, 2007.
17. Pitisuttithum P, Rerks-Ngarm S, Kaewkungwal J et al. Women participation in the Phase III efficacy trial of ALVAC HIV-1 vaccine priming, AIDSVAX vaccine boosting in Thailand. Presented at: AIDS Vaccine 2007. Seattle, WA, USA, 20-23 August, 2007.
18. Premsri N, Namwat C, Rerks-Ngarm S et al. Integration of community engagement activities support the prime-boost Phase III HIV vaccine trial in Thailand. Presented at: AIDS Vaccine 2007. Seattle, WA, USA, 20-23 August, 2007.
19. Hammer S, Miller M, Pape J et al. Safety and immunogenicity of the MRKAd5 gag HIV-1 vaccine in a worldwide Phase I study of healthy adults (Merck V520-018/HVTN 050). Presented at: AIDS Vaccine 2007. Seattle, WA, USA, 20-23 August, 2007.
20. Steinbrook R. One step forward, two steps back - will there ever be an AIDS vaccine? N. Engl. J. Med. 357(26), 2653-2655 (2007).
21. Pitisuttithum P. HIV vaccine research in Thailand national perspective: overview of HIV vaccine research in Thailand. In: HIV Vaccine Research and Development in Thailand. Pitisuttithum P, Francis DP, Esparza J, Thongcharoen P (Eds). Amarin Printing and Publishing Public Company, Bangkok, Thailand 83-92 (2006).