Influence of ultra-low dose Aprotinin on thoracic surgical operations: A prospective randomized trial

Journal of Cardiothoracic Surgery

Volumn 3, Issue 1, 2008, Pages

  Apostolakis, Efstratios ^a   Panagopoulos, Nikolaos ^a   Koletsis, Efstratios N ^a   Crockett, James ^a   Stamou Kouki, Helen ^a   Sourgiadaki, Efrosini ^a   Filos, Kriton ^a   Dougenis, Dimitrios ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; HEMOSTATIC AGENT;

ARTICLE; BLEEDING; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; LENGTH OF STAY; MALE; METHODOLOGY; MIDDLE AGED; PEROPERATIVE CARE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICS; THORAX DISEASE; THORAX SURGERY; TREATMENT OUTCOME;

APROTININ; BLOOD LOSS, SURGICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HEMOSTATICS; HUMANS; INCIDENCE; INJECTIONS, INTRAVENOUS; INTRAOPERATIVE CARE; LENGTH OF STAY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; THORACIC DISEASES; THORACIC SURGICAL PROCEDURES; TREATMENT OUTCOME;

EID: 41949140992     PISSN: None     EISSN: 17498090     Source Type: Journal    
DOI: 10.1186/1749-8090-3-14     Document Type: Article

References (20)

1. Despotis G Skubas N Goodnough L Optimal management of bleeding and transfusion in patients undergoing cardiac surgery Semin Thorac Cardiovasc Surg 1999, 11:84-104. 10378853
2. Burke S Faber P Complications of pulmonary resection Complications in Cardiothoracic Surgery. Avoidance and Treatment New York, Blackwell Futura Little A 2004, 67-91.
3. Peters D Noble S Aprotinin: An update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery Drugs 1999, 2:233-260. 10.2165/00003495-199957020-00015
4. Royston D Taylor K Bidstrup B Sapaford R Effect of aprotinin on need for blood transfusion after repeat open-heart surgery Lancet 1987, 2:1289-1291. 10.1016/S0140-6736(87)91190-1 2446091
5. Kyriss T Wurst H Friedel G Jaki R Toomes H Reduced blood loss by aprotinin in thoracic surgical operations associated with high risk of bleeding. A placebo-controlled randomized phase IV study Eur J Cardiothorac Surgery 2001, 20:38-41. 10.1016/S1010-7940(01)00762-X
6. Bedirhan M Turna A Yagan N Tasci O Aprotinin reduces postoperative bleeding and the need for blood products in thoracic surgery: Results of a randomized double-blind study Eur J Cardiothorac Surgery 2001, 20:1122-1127. 10.1016/S1010-7940(01)01016-8
7. Kaetzel R Keuper H Wiedemann B Brethner L Voigt B Effects of aprotinin application on perioperative changes in hemostasis and fibrinolysis and its consequence for blood loss and transfusion requirement in lung surgery Infusionther Transfusions Med 1998, 25:236-245. 10.1159/000053430
8. Mojcik C Levy J Aprotinin and the systemic inflammatory response following cardiopulmonary bypass Ann Thorac Surg 2001, 71:745-754. 10.1016/S0003-4975(00)02218-9 11235755
9. Sedrakyan A Treasure T Elefteriadis J Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials J Thorac Cardiovasc Surg 2004, 128:442-448. 10.1016/j.jtcvs.2004.03.041 15354106
10. Dignan RJ Law W Seah P Manganas C Newman D Grant P Wolfenden D Ultra-low dose Aprotinin decreases transfusion requirements and its cost effective in coronary operations Ann Thorac Surg 2001, 71:158-164. 10.1016/ S0003-4975(00)01860-9 11216738
11. Garcia H Domenech P Sabate A The prophylactic effect of aprotinin on intraoperative bleeding in liver transplantation Hepatology 1997, 25:1143-1148. 10.1002/hep.510260509
12. Kasper S Elsner F Hilgers D Grond S Rutt S A retrospective study of the effects of small dose aprotinin on blood loss and transfusion needs during total hip arthroplasty Eur J Anesthesiol 1998, 15:669-675.
13. Sirbu H Busch T Aleksic I Lofti S Ruschewski W Dalichau H Chest re-exploration for complications after lung surgery Thorac Cardiovasc Surg 1999, 47:73-76. 10363604
14. Asimakopoulos G Thompson R Nourshargh S Lidington E Mason J Ratnatunga C Haskard D Taylor K Landis C An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation J Thorac Cardiovasc Surg 2000, 120:361-369. 10.1067/mtc.2000.106323 10917955
15. Dougenis D Patrinou V Filos KS Theodori E Vagianos K Maniati A Blood use in lung resection for carcinoma:pErioperative elective anemia does not compromise the early outcome Eur J Cardiothorac Surg 2000, 20:372-377. 10.1016/S1010-7940(01)00792-8
16. Hill G Alonso A Spurzem J Stammers A Robbins R Aprotinin and methylprednizolone equally blunt cardiopulmonary bypass-induced inflammation in humans J Thorac Cardiovasc Surgery 1995, 110:1658-1662. 10.1016/S0022-5223(95)70027-7
17. Wakelin MW Sanz MJ Dewar A Albelda SM Larkin SW Boughton-Smith N An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane J Exp Med 1996, 184:229-239. 10.1084/jem.184.1.229 8691137
18. Nourshargh S Larkin SW Das A Williams TJ Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor Blood 1995, 85:2553-2558. 7727783
19. Davis R Whittington R Aprotinin: A review of its pharmacology and therapeutic efficiency in reducing blood loss associated with cardiac surgery Drugs 1995, 49:954-983. 10.2165/00003495-199549060-00008 7543841
20. Vaporciyan A Putnam J Smythe R The potential role of aprotinin in the peroperative management of malignant tumors J Am Coll Surg 2004, 198:266-78. 10.1016/j.jamcollsurg.2003.09.022 14759785