Electron paramagnetic resonance investigation on modulatory effect of benidipine on membrane fluidity of erythrocytes in essential hypertension

Heart and Vessels

Volumn 23, Issue 2, 2008, Pages 134-139

  Tsuda, Kazushi ^a,b  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b KANSAI UNIVERSITY OF HEALTH SCIENCES   (Japan)

Author keywords

Benidipine; Electron paramagnetic resonance; Erythrocyte; Hypertension; Membrane fluidity; Oral administration

Indexed keywords

ARGININE; BENIDIPINE; NITRIC OXIDE; NITROXIDE DERIVATIVE; STEARIC ACID DERIVATIVE;

ADULT; AGED; ARTICLE; BLOOD RHEOLOGY; CELL FUNCTION; CELL MEMBRANE FLUIDITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ERYTHROCYTE MEMBRANE; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLITE; MICROCIRCULATION; PRIORITY JOURNAL; SPIN LABELING; TREATMENT DURATION; VISCOSITY; VOLUNTEER;

ADMINISTRATION, ORAL; AGED; ANTIHYPERTENSIVE AGENTS; ARGININE; BLOOD PRESSURE; BLOOD VISCOSITY; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; ERYTHROCYTE MEMBRANE; FEMALE; HUMANS; HYPERTENSION; MALE; MEMBRANE FLUIDITY; MIDDLE AGED; NITRIC OXIDE; TREATMENT OUTCOME;

EID: 41949140755     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-007-1017-6     Document Type: Article

References (32)

1. Resnick LM, Barbagallo M, Dominquez LJ, Veniero JM, Nicholson JP, Gupta RK (2001) Relation of cellular potassium to other mineral ions in hypertension and diabetes. Hypertension 38:709-712
2. McLaren Y, Kreutz R, Lindpaintner K, Bohr DF, Ganten D, Reid JL, Dominiczak AF (1993) Membrane microviscosity does not correlate with blood pressure: A cosegregation study. J Hypertens 11:25-30
3. Buskurt OK, Meiselman HJ (2003) Blood rheology and hemodynamics. Semin Thromb Hemost 29:435-450
4. Tsuda K, Nishio I (2003) Membrane fluidity and hypertension. Am J Hypertens 16;259-261
5. Hollan S (1996) Membrane fluidity of blood cells. Haematologia 27:109-127
6. Zicha J, Kunes J, Devynck MA (1999) Abnormalities of membrane function and lipid metabolism in hypertension. Am J Hypertens 12:315-331
7. Tsuda K, Iwahashi H, Minatogawa Y, Nishio I, Kido R, Masuyama Y (1987) Electron spin resonance studies of erythrocytes from spontaneously hypertensive rats and humans with essential hypertension. Hypertension 9(suppl III):III-19-III-24
8. Tsuda K, Kinoshita Y, Nishio I, Masuyama Y (1999) Adrenomedullin and membrane fluidity of erythrocytes in mild essential hypertension. J Hypertens 17:201-210
9. Tsuda K, Kinoshita Y, Kimura K, Nishio I, Masuyama Y (2001) Electron paramagnetic resonance investigation on modulatory effect of 17β-estradiol on membrane fluidity of erythrocytes in postmenopausal women. Arterioscler Thromb Vasc Biol 21:1306-1312
10. Tsuda K, Kimura K, Nishio I, Masuyama Y (2000) Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension-an electron paramagnetic resonance investigation-. Biochem Biophys Res Commun 275:946-954
11. Karasawa A, Kubo K, Oka T, Nakamizo N (1988) Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious spontaneously hypertensive rats. Arzneimittelforschung 38:1691-1694
12. Karasawa A, Kubo K (1988) Calcium antagonistic effects and the in vitro duration of actions of KW-3049, a new 1,4-dihydropyridine derivative, in isolated canine coronary arteries. Jpn J Pharmacol 47:35-44
13. Kobayashi N, Kobayashi K, Hara K, Higashi T, Yanaka H, Yagi S, Matsuoka H (1999) Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats. Am J Hypertens 12:483-491
14. Dohi Y, Kojima M, Sato K (1996) Benidipine improves endothelial function in renal resistance arteries of hypertensive rats. Hypertension 28:58-63
15. Yamashita T, Kawashima S, Ozaki M, Rikitake Y, Hirase T, Inoue N, Hirata K, Yokoyama M (2002) A calcium channel blocker, benidipine, inhibits intimal thickening in the carotid artery of mice by increasing nitric oxide production. J Hypertens 19:451-458
16. Tsuda K, Nishio I (2004) A calcium channel blocker, benidipine, improves cell membrane fluidity in human subjects via a nitric oxide-dependent mechanism. An electron paramagnetic resonance investigation. Am J Hypertens 17:1143-1150
17. Sato B, Nishikida K, Samuels LT, Tyler FH (1987) Electron spin resonance studies of erythrocytes from patients with Duchenne muscular dystrophy. J Clin Invest 61:251-259
18. Simon I (1979) Differences in membrane unsaturated fatty acids and electron spin resonance in different types of myeloid leukemia cells. Biochim Biophys Acta 556:408-422
19. Fujiwara N, Osanai T, Kamada T, Katoh T, Takahashi K, Okumura K (2000) Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension-modulation of nitric oxide synthesis by salt intake. Circulation 101:856-861
20. Barbagallo M, Shan J, Pang PK, Resnick LM (1995) Glucoseinduced alterations of cytosolic free calcium in cultured rat tail artery vascular smooth muscle cells. J Clin Invest 95:763-767
21. Puikuan K, Chunyu Z, Jin F, Chaoshu T, Junbao D (2006) Inhalation of nebulized nitroglycerin, a nitric oxide donor, for the treatment of pulmonary hypertension induced by high pulmonary blood flow. Heart Vessels 21:169-179
22. Matsubara M, Yao K, Hasegawa K (2006) Benidipine, a dihydropyridine-calcium channel blocker, inhibits lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release. Pharmacol Res 53:35-43
23. Kitakaze M, Node K, Minamino T, Asanuma H, Kuzuya T, Hori M (1999) A Ca channel blocker, benidipine, increases coronary blood flow and attenuates the severity of myocardial ischemia via NO-dependent mechanism in dogs. J Am Coll Cardiol 33:242-249
24. Jubelin BC, Gierman JL (1996) Erythrocytes may synthesize their own nitric oxide. Am J Hypertens 9:1214-1219
25. Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I, Gharini P, Kabanova S, Ozuyaman B, Schnurch HG, Godecke A, Weber AA, Robenek M, Robenek H, Bloch W, Rosen P, Keim M (2006) Red blood cells express a functional endothelial nitric oxide synthase. Blood 107:2943-2951
26. Mesquita R, Picarra B, Saldanha C, Martins E, Silva J (2002) Nitric oxide effects on human erythrocyte structural and functional properties-an in vitro study. Clin Hemorheol Microcirc 27:137-147
27. Shiraishi K, Matsuzaki S. Ishida H, Nakazawa H (1993) Impaired erythrocyte deformability and membrane fluidity in alcoholic liver disease: Participation in disturbed hepatic microcirculation. Alcohol Alcohol 1A(Suppl):59-64
28. Takase H, Sugiyama M, Nakazawa A, Sato K, Ueda R, Dohi Y (2000) Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension. Arzneimittelforschung 50:530-534
29. Recchia F, Vogel TR, Hintze TH (2000) NO metabolites accumulate in erythrocytes in proportion to carbon dioxide and bicarbonate concentration. Am J Physiol Heart Circ Physiol 278:H852-H856
30. Ishibashi T, Kubota K, Himeno M, Matsubara T, Hori T, Ozaki K, Yamazoe M, Aizawa Y, Yoshida J, Nishio M (2001) Respiratory alkalosis does not alter NOx concentrations on human plasma and erythrocytes. Am J Physiol Heart Circ Physiol 281:H2757-H2761
31. Rogers SC, Khalatbari A, Gapper PW, Frenneaux MP, James PE (2005) Detection of human red blood cell-bound nitric oxide. J Biol Chem 280:26720-26728
32. 2+-induced endothelium-dependent relaxation of blood vessels and blood pressure lowering: Role of NO. Am J Physiol 278:R628-R639