Rebampide enema therapy as a treatment for patients with chronic radiation proctitis: Initial treatment or when other methods of conservative management have failed

International Journal of Colorectal Disease

Volumn 23, Issue 6, 2008, Pages 629-633

  Kim, Tae Oh ^a,b   Song, Geun Am ^a   Lee, Sun Mi ^a   Kim, Gwang Ha ^a   Heo, Jeong ^a   Kang, Dae Hwan ^a   Cho, Mong ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

Author keywords

Complication; Radiation proctitis; Rebamipide

Indexed keywords

ENEMA; MESALAZINE; REBAMIPIDE; SUCRALFATE;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARGON PLASMA COAGULATION; ARTICLE; BEDTIME DOSAGE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL FEATURE; CONSERVATIVE TREATMENT; DEFECATION; DRUG EFFICACY; DRUG SAFETY; ENDOMETRIUM CANCER; FEMALE; HUMAN; MEDICAL ASSESSMENT; MORNING DOSAGE; OUTCOME ASSESSMENT; PELVIS CANCER; PRIORITY JOURNAL; PROCTITIS; RECTOSCOPY; RECTUM HEMORRHAGE; SCORING SYSTEM; SIGMOIDOSCOPY; SYMPTOM; TELANGIECTASIA; TENESMUS; TREATMENT FAILURE; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA;

AGED; ALANINE; ANTIOXIDANTS; ENEMA; FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; MIDDLE AGED; PROCTITIS; QUINOLONES; RADIATION INJURIES;

EID: 41949139323     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-008-0453-9     Document Type: Article

References (34)

1. Beard CJ, Propert KJ, Rieker PP, Clark JA, Kaplan I, Kantoff PW, Talcott JA (1997) Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: A prospective multiinstitutional outcomes study. J Clin Oncol 15:223-229
2. Crook J, Esche B, Futter N (1996) Effect of pelvic radiotherapy for prostate cancer on bowel, bladder, and sexual function: The patient's perspective. Urology 47:387-394
3. Johnston MJ, Robertson GM, Frizelle FA (2003) Management of late complications of pelvic radiation in the rectum and anus. Dis Colon Rectum 46:247-259
4. Tagkalidis PP, Tjandra J (2001) Chronic radiation proctitis. ANJ J Surg 71:230-237
5. Kennedy M, Bruninga K, Mutlu EA, Losurdo J, Choudhary S, Keshavarzian A (2001) Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E & C. Am J Gastroenterol 96:1080-1084
6. Goldstein F, Khoury J, Thorton JJ (1976) Treatment of chronic radiation enteritis and colitis with salicylazosulfapyridine and systemic corticosteroids. Am J Gastroenterol 65:201-208
7. Kochhar R, Patel F, Dhar A, Sharma SC, Ayyagari S, Aggarwal R, Goenka MK, Gupta BD, Mehta SK (1991) Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. Dig Dis Sci 36:103-107
8. Kochhar R, Sharma SC, Gupta BB, Mehta SK (1988) Rectal sucralfate in radiation proctitis. Lancet 13:400
9. Kochhar R, Sriram PV, Sharma SC, Goel RC, Patel F (1999) Natural history of late radiation proctosigmoiditis treated with topical sucralfate suspension. Dig Dis Sci 44:973-978
10. Vernia P, Fracasso PL, Casale V, Villotti G, Marcheggiano A, Stigliano V, Pinnaro P, Bagnardi V, Caprilli R (2000) Topical butyrate for acute radiation proctitis: Randomized crossover trial. Lancet 356:1232-1235
11. Charneau J, Bouachour G, Person B, Burtin P, Ronceray J, Boyer J (1991) Severe hemorrhagic radiation proctitis advancing to gradual cessation with hyperbaric oxygen. Dig Dis Sci 36:373-375
12. Aihara M, Imagawa K, Funakoshi Y, Ohmoto Y, Kikuchi M (1998) Effects of rebamipide on production of several cytokines by human peripheral blood mononuclear cells. Dig Dis Sci 43:160S-166S
13. Nagano C, Azuma A, Ishiyama H, Sekiguchi K, Imagawa K, Kikuchi M (2001) Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. J Pharmacol Exp Ther 297:388-394
14. Kishimoto S, Haruma K, Tari A, Sakurai K, Nakano M, Nakagawa Y (2000) Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats. Dig Dis Sci 45:1608-1616
15. Watanabe S, Wang XE, Hirose M, Yoshizawa T, Iwazaki R, Oide H, Kitamura T, Miwa H, Miyazaki A, Sato N (1996) Effects of rebamipide on bile acid-induced inhibition of gastric epithelial repair in a rabbit culture model. Aliment Pharmacol Ther 10:927-932
16. Kleine A, Kluge S, Peskar B (1993) Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats. Dig Dis Sci 38:1441-1449
17. Coia LR, Myerson RJ, Tepper JE (1995) Late effects of radiation therapy on the gastrointestinal tract. Int J Radiat Oncol Biol Phys 31:1213-1236
18. Eifel PJ (2000) Radiation therapy. In: Berek JS, Hacker NF (eds) Practical gynecologic oncology. Lippincott Williams & Wilkins, Philadelphia, PA, pp 117-158
19. Talley NA, Chen F, King D, Jones M, Talley NJ (1997) Short chain fatty acids in the treatment of radiation proctitis. Dis Colon Rectum 40:1046-1050
20. Baum CA, Biddle WL, Miner PB (1989) Failure of 5-aminosalicylic acid enemas to improve chronic radiation proctitis. Dig Dis Sci 34:758-760
21. de Parades V, Bauer P, Girodet J, Marteau P, Parisot C, Atienza P (1998) Non-surgical treatment of chronic radiation proctitis. Gastroenterol Clin Biol 22:688-696
22. Kaassis M, Oberti E, Burtin P, Boyer J (2000) Argon plasma for the treatment of hemorrhagic radiation proctitis. Endoscopy 32:673-676
23. Kleine A, Kluge S, Peskar BM (1993) Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats. Dig Dis Sci 38:1441-1449
24. Sun WH, Tsuji S, Tsujii M, Gunawan ES, Kawai N, Kimura A, Kakiuchi Y, Yasumaru M, Iijima H, Okuda Y, Sasaki Y, Hori M, Kawano S (2000) Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. J Pharmacol Exp Ther 295:447-452
25. Suetsugu H, Ishihara S, Moriyama N, Kazumori H, Adachi K, Fukuda R, Watanabe M, Kinoshita Y (2000) Effect of rebamipide on prostaglandin EP4 receptor gene expression in rat gastric mucosa. J Lab Clin Med 136:50-57
26. Takahashi M, Takada H, Takagi K, Kataoka S, Soma R, Kuwayama H (2003) Gastric restitution is inhibited by dexamethasone, which is reversed by hepatocyte growth factor and rebamipide. Alim Pharmacol Ther 18(Suppl 1):126-132
27. Watanabe T, Higuchi K, Hamaguchi M, Tanigawa T, Wada R, Tominaga K, Fujiwara Y, Arakawa T (2002) Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils. Dig Dis Sci 47:1582-1589
28. Sakurai K, Osaka T, Yamasaki K (1998) Protection by rebamipide against acetic acid-induced colitis in rats: Relationship with its antioxidative activity. Dig Dis Sci 43(9 Sppl):125S-133S
29. Akamatsu T, Nakamura N, Furuya N, Shimizu T, Gotou A, Kiyosawa K, Katsuyama T, Osumi T, Hirao Y, Miyamoto G (2002) Local gastric and serum concentrations of rebamipide following oral ingestion in healthy volunteers. Dig Dis Sci 47:1399-1404
30. Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K (1995) Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer: Comparison with cimetidine. Dig Dis Sci 40:2469-2472
31. Okayama M, Tsubouchi R, Nishio H, Kato S, Takeuchi K (2004) Protective effect of intra-rectal administration of rebamipide on dextran sulfate sodium-induced colitis. Digestion 70:240-249
32. Nakashima T, Maeda T, Nagamoto H, Kumakura T, Takai M, Mori T (2005) Rebamipide enema is effective for treatment of experimental dextran sulfate sodium induced colitis in rats. Dig Dis Sci 50(Suppl 1):S124-131
33. Miyata M, Kasugai K, Ishikawa T, Kakumu S, Onishi M, Mori T (2005) Rebamipide enema-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis. Dig Dis Sci 50(Suppl 1):S119-123
34. Makiyama K, Takeshima F, Hamamoto T (2005) Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: A prospective study report. Dig Dis Sci 50:2323-2329