Genotoxic and cytotoxic effects of manganese chloride in cultured human lymphocytes treated in different phases of cell cycle

Toxicology in Vitro

Volumn 22, Issue 4, 2008, Pages 1032-1037

  Lima, P D L ^a   Vasconcellos, M C ^b   Bahia, M O ^a   Montenegro, R C ^b   Pessoa, C O ^b   Costa Lotufo, L V ^b   Moraes, M O ^b   Burbano, R R ^a  

^a FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Chromosome aberration; Comet assay; Manganese chloride

Indexed keywords

DNA; MANGANESE CHLORIDE;

ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CHROMOSOME ABERRATION; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; MITOSIS; POLYPLOIDY;

CELL CYCLE; CELLS, CULTURED; CHLORIDES; CHROMOSOME ABERRATIONS; COMET ASSAY; ENVIRONMENTAL POLLUTANTS; HUMANS; LYMPHOCYTES; MANGANESE COMPOUNDS; MITOTIC INDEX; MUTAGENICITY TESTS; MUTAGENS; TIME FACTORS;

EID: 41949138946     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.12.011     Document Type: Article

References (36)

1. Ayres, M., Ayres, Jr., M., Ayres, D.L., Santos, A.S., 2000. Bioestat 2.0. Belém. Sociedade Civil Mamirauá, p. 272.
2. Barceloux D.G. Manganese. Journal of Toxicology: Clinical Toxicology 37 (1999) 293-307
3. Brega S.M., Vassilieff I., Almeida A., Mercadante A., Bissacot D., Cury P.R., and Freire-Maia D.V. Clinical, cytogenetic and toxicological studies in rural workers exposed to pesticides in Botucatu, São Paulo, Brazil. Reports in Public Health 14 (1998) 109-115
4. Calne D.B., Chu N.S., Huang C.C., Lu C.S., and Olanow W. Manganism and idiopathic Parkinsonism: similarities and differences. Neurology 44 (1994) 1583-1586
5. Chen M.T., Cheng G.W., Lin C.C., Chen B.H., and Huang Y.L. Effects of acute manganese chloride exposure on lipid peroxidation and alteration of trace metals in rat brain. Biological Trace Element Research 110 (2006) 163-178
6. Dhawan A., Kayani M.A., Parry J.M., Parry E., and Anderson D. Aneugenic and clastogenic effects of doxorubicin in human lymphocytes. Mutagenesis 18 (2003) 487-490
7. De Meo M., Laget M., Castegnaro M., and Dumenil G. Genotoxic activity of potassium permanganate in acidic solutions. Mutation Research 260 (1991) 295-306
8. Eriksson H., and Heilbronn E. Changes in the redox state of neuroblastoma cells after manganese exposure. Archives of Toxicology 54 (1983) 53-59
9. Ferrer A. Metal poisoning. Anales del Sistema Sanitario de Navarra 26 (2003) 141-153
10. Galloway S.M., Aardema M.J., Ishidate Jr. M., Ivett J.L., Kirkland D.J., Morita T., Mosesso P., and Sofuni T. Report from working group on in vitro tests for chromosomal aberrations. Mutation Research 312 (1994) 241-261
11. Galloway S.M. Cytotoxicity and chromosome aberrations in vitro: experience in industry and the case for an upper limit on toxicity in the aberration assay. Environmental and Molecular Mutagenesis 35 (2000) 191-200
12. Ganrot P.O. Metabolism and possible health effects of aluminum. Environmental Health Perspectives 65 (1986) 363-441
13. Gerber G.B., Leonard A., and Hantson P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Critical Reviews in Oncology/Hematology 42 (2002) 25-34
14. Goldoni M., Vettori M.V., Alinovi R., Gaglieri A., Ceccatelli S., and Mutti A. Models of neurotoxicity: extrapolation of benchmark doses in vitro. Risk Analysis 23 (2003) 505-514
15. Gutiérrez J.B., and Salsamendi A.L. Fundamentos da Ciência Toxicológica (2001), Diaz de Santos, Madri 123 pp.
16. Hartmann A., and Speit G. The contribution of cytotoxicity to DNA effects in the single cell gel test (comet assay). Toxicology Letters 90 (1997) 183-188
17. Isaac A.O., Kawikova I., Bothwell A.L.M., Daniels C.K., and Lai J.C.K. Manganese treatment modulates the expression of peroxisome proliferator-activated receptors in astrocytoma and neuroblastoma cells. Neurochemical Research 31 (2006) 1305-1316
18. Khan K.N., Andress J.M., and Smith P.F. Toxicity of subacute intravenous manganese chloride administration in beagle dogs. Toxicologic Pathology 25 (1997) 344-350
19. Keen C.L., Ensunsa J.L., Watson M.H., Baly D.L., Donovan S.M., Monaco M.H., and Clegg M.S. Nutritional aspects of manganese from experimental studies. Neurotoxicology 20 (1999) 213-223
20. Lima P.D., Leite D.S., Vasconcellos M.C., Cavalcanti B.C., Santos R.A., Costa-Lotufo L.V., Pessoa C., Moraes M.O., and Burbano R.R. Genotoxic effects of aluminum chloride in cultured human lymphocytes treated in different phases of cell cycle. Food and Chemical Toxicology 45 (2007) 1154-1159
21. Moorhead P.S., Nomell P.C., Mellman W.J., Battips D.M., and Hungerford D.A. Chromosome preparations of leukocytes cultured from human peripheral blood. Experimental Cell Research 20 (1960) 613-616
22. Ogawa H.I., Shibahara T., Iwata H., Okada T., Tsuruta S., Kakimoto K., Sakata K., Kato Y., Ryo H., and Itoh T. Genotoxic activities in vivo of cobaltous chloride and other metal chlorides as assayed in the Drosophila wing spot test. Mutation Research 320 (1994) 133-140
23. Ose D.E., and Fridovich I. Superoxide dismutase. Reversible removal of manganese and its substitution by cobalt, nickel or zinc. The Journal of Biological Chemistry 251 (1976) 1217-1218
24. Pifl C., Khorchide M., Kattinger A., Reither H., Hardy J., and Hornykiewicz O. α-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter. Neuroscience Letters 354 (2004) 34-37
25. Pittman J.K. Managing the manganese: molecular mechanisms of manganese transport and homeostasis. The New Phytologist 167 (2005) 733-742
26. Preston R.J., San Sebastian J.R., and McFee A.F. The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents. Mutation Research 189 (1987) 175-183
27. Purdey M. Elevated levels of ferrimagnetic metals in food chains supporting the Guam cluster of neurodegeneration: do metal nucleated crystal contaminants evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?. Medical Hypotheses 63 (2004) 793-809
28. Roth J.A., and Garrick M.D. Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochemical Pharmacology 66 (2003) 1-13
29. 2. Toxicology in Vitro 21 (2006) 284-292
30. Shi H., Hudson L.G., and Liu K.J. Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radical Biology & Medicine 37 (2004) 582-593
31. Singh N.P., Mccoy M.T., Tice R.R., and Schneider E.L.A. Single technique for quantitation of low levels of DNA damage in individual cells. Experimental Cell Research 175 (1988) 184-191
32. Speit G., and Hartmann A. The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Methods in Molecular Biology 113 (1999) 203-212
33. Timchenko O.I., ParańKo N.M., Shantyr E.E., and KuźMenko S.D. The cytogenetic effects of separate and combined exposures to a manganese dioxide aerosol and wide-band noise. Gigiena i Sanitariia 11 (1991) 70-72
34. Veldman B.A., Wijn A.M., Knoers N., Praamstra P., and Horstink M.W. Genetic and environmental risk factors in Parkinson's disease. Clinical Neurology and Neurosurgery 100 (1998) 15-26
35. Wagner E.D., Anderson D., Dhawan A., Rayburn A.L., and Plewa M.J. Evaluation of EMS-induced DNA damage in the single cell gel electrophoresis (comet) assay and with flow cytometric analysis of micronuclei. Teratogenesis, Carcinogenesis and Mutagenesis 2 (2003) 1-11
36. World Health Organization (WHO), 1999. Manganese and its compounds. Concise International Chemical Assessment Document 12. WHO, Geneva.