Application of parallel gradient high performance liquid chromatography with ultra-violet, evaporative light scattering and electrospray mass spectrometric detection for the quantitative quality control of the compound file to support pharmaceutical discovery

Journal of Chromatography A

Volumn 1189, Issue 1-2, 2008, Pages 101-108

  Squibb, Anthony W ^a   Taylor, Mark R ^a   Parnas, Barry L ^b   Williams, Gareth ^a   Girdler, Richard ^a   Waghorn, Peter ^a   Wright, Adrian G ^a   Pullen, Frank S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

ELSD; Parallel gradient; Quantitative quality control; QUARC

Indexed keywords

CONCENTRATION (PROCESS); DRUG PRODUCTS PLANTS; ELECTROSPRAY IONIZATION; GRAVIMETRIC ANALYSIS; LIGHT SCATTERING; MASS SPECTROMETRY; QUALITY CONTROL;

INHERENT INACCURACIES; PARALLEL GRADIENT; QUANTITATIVE QUALITY CONTROL; SCREENING FILES;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

5 PHENYL 5 (PARA TOLYL)HYDANTOIN; ALTIZIDE; AMITRIPTYLINE; AMLODIPINE; CHLOROTHIAZIDE; CHLORPHENIRAMINE; CHLORTALIDONE; CORTISONE; CP 52608; DILTIAZEM; FLUCONAZOLE; FUROSEMIDE; IBUPROFEN; INDOPROFEN; KETOPROFEN; LABETALOL; MIANSERIN; NICARDIPINE; NORTRIPTYLINE; SILDENAFIL; SULFADIMETHOXINE; SULFAMETHOXAZOLE; SUPROFEN; THIOFLAVINE; TRIAMCINOLONE ACETONIDE; TRICHLORMETHIAZIDE; UK 11147; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

ACCURACY; ARTICLE; CALIBRATION; CONCENTRATION (PARAMETERS); DRUG PURITY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; PRIORITY JOURNAL; QUALITY CONTROL; ULTRAVIOLET SPECTROPHOTOMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; MODELS, THEORETICAL; SCATTERING, RADIATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 41949126061     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.11.017     Document Type: Article

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