Lactate concentration in umbilical cord blood is gestational age-dependent: A population-based study of 17 867 newborns

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 115, Issue 6, 2008, Pages 704-709

  Wiberg, N ^a   Kallen K ^b   Herbst, A ^a   Aberg A ^a   Olofsson, P ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF LUND   (Sweden)

Author keywords

Apgar score; Blood gases; Gestational age; Lactate; Umbilical cord blood

Indexed keywords

LACTIC ACID;

APGAR SCORE; ARTERIAL BLOOD; ARTICLE; BLOOD GAS ANALYSIS; BLOOD SAMPLING; COMPARATIVE STUDY; FEMALE; GESTATIONAL AGE; HUMAN; LACTATE BLOOD LEVEL; LINEAR REGRESSION ANALYSIS; NEWBORN; POPULATION RESEARCH; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; UNIVERSITY HOSPITAL; VAGINAL DELIVERY; VENOUS BLOOD;

BICARBONATES; BLOOD GAS ANALYSIS; CARBON DIOXIDE; FETAL BLOOD; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; LACTATES; REFERENCE VALUES; UMBILICAL ARTERIES; UMBILICAL VEINS;

EID: 41949117715     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2008.01707.x     Document Type: Article

References (26)

1. Nicolaides KH, Economides DL, Soothill PW. Blood gases, pH, and lactate in appropriate- and small-for-gestational-age fetuses. Am J Obstet Gynecol 1989 161 : 996 1001.
2. Soothill PW, Nicolaides KH, Rodeck CH, Campbell S. Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Ther 1986 1 : 168 75.
3. Kitlinski ML, Källén K, Marsál K, Olofsson P. Gestational age-dependent reference values for pH in umbilical cord arterial blood at term. Obstet Gynecol 2003 102 : 338 45.
4. Wiberg N, Källén K, Olofsson P. Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age. Early Hum Dev 2006 82 : 583 9.
5. Wiberg N, Källén K, Olofsson P. Base deficit estimation in umbilical cord blood is influenced by gestational age, choice of fetal fluid compartment and algorithm for calculation. Am J Obstet Gynecol 2006 195 : 1651 6.
6. Skurup A. Storage Recommendations for Blood Gas Samples. Bulletin, Vol. 31. Brönshöj, Denmark : Radiometer Medical A/S, 2005.
7. Westgate JA, Rosén KG. Acid base balance at birth. In : Van Geijn HP, Copray FJA, editors. A Critical Appraisal of Fetal Surveillance. Amsterdam : Elsvier Science B.V 1994 : 595 602.
8. Siggaard-Andersen O. The Acid-Base Status of the Blood, 4th edn. Copenhagen, Denmark : Villadsen & Christensen, 1976.
9. ACOG. Use and abuse of the Apgar score. Int J Obstet Gynecol 1996 174 : 303 5.
10. Catlin EA, Carpenter MW, Brann BS 4th., Mayfield SR, Shaul PW, Goldstein M, et al. The Apgar score revisited: influence of gestational age. J Pediatr 1986 109 : 865 8.
11. Rooth G. Perinatal Acid-Base Balance. Lund, Sweden : Studentlitteratur, 1988.
12. Suidan JS, Antoine C, Silverman F, Lustg ID, Wasserman JF, Young BK. Human maternal-fetal relationships. J Perinat Med 1984 12 : 211 17.
13. Kenepp NB, Shelley WC, Gabbe SG, Kumar S, Stanley CA, Gutsche BB. Fetal and neonatal hazards of maternal hydration with 5% dextrose before caesarean section. Lancet 1982 319 : 1150 2.
14. Philipson EH, Kalhan SC, Riha MM, Pimentel R. Effects of maternal glucose infusion on fetal acid-base status in human pregnancy. Am J Obstet Gynecol 1987 157 : 866 73.
15. Nordström L, Arulkumaran S, Chua S, Ratnam S, Ingemarsson I, Kublickas M, et al. Continuous maternal glucose infusion during labor; effects on maternal and fetal glucose and lactate levels. Am J Perinatol 1995 12 : 357 62.
16. Piquard F, Hsiung R, Schaeffer A, Haberey P, Dellenbach P. Does fetal acidosis develop with maternal glucose infusion during normal labour? Obstet Gynecol 1989 74 : 909 14.
17. Westgren M, Carlsson C, Lindholm T, Thysell H, Ingemarsson I. Continuous maternal glucose measurements and fetal glucose and insulin levels after administration of terbutaline in term labor. Acta Obstet Gynecol Scand Suppl 1982 108 : 63 5.
18. Nordström L. Fetal lactate levels during labour and at delivery determined with test strip methods. Stockholm : Karolinska Institute Thesis, 1995. ISBN 916281707-8.
19. Hägnevik K, Faxelius G, Irestedt L, Lagercrantz H, Lundell B, Persson B. Catecholamine surge and metabolic adaptation in the newborn after vaginal delivery and caesarean section. Acta Paediatr Scand 1984 73 : 602 9.
20. Nordström L, Marcus C, Persson B, Shimojo N, Westgren M. Lactate in cord blood and its relation to pH and catecholamines in spontaneous vaginal deliveries. Early Hum Dev 1996 46 : 97 104.
21. Nordström L, Chua S, Roy A, Naka K, Persson B, Arulkumaran S. Lactate, lactate/pyruvate ratio and catecholamine interrelations in cord blood at delivery in complicated pregnancies. Early Hum Dev 1998 52 : 87 94.
22. Katz M, Lunenfeld E, Meizner I, Bashan N, Gross J. The effect of the duration of the second stage of labour on the acid-base state if the fetus. Br J Obstet Gynaecol 1987 94 : 425 30.
23. Nordström L, Achanna S, Naka K, Arulkumaran S. Fetal and maternal lactate increase during active second stage of labour. BJOG 2001 108 : 263 8.
24. Piquard F, Schaefer A, Dellenbach P, Haberey P. Is fetal acidosis in the human fetus maternogenic during labor? A reanalysis. Am J Physiol 1991 261 : 1294 9.
25. Sinn JK, Lloyd J, Todd DA, Lazarus R, Maesel A, John E. Umbilical cord blood lactate in normal infants: comparison between two methods of measurement. J Paediatr Child Health 2001 37 : 42 7.
26. Wiberg N, Källén K, Olofsson P. Delayed umbilical cord clamping at birth has effects on arterial and venous blood gases and lactate concentration. BJOG 2008 115 : 697 703.