Time dependent gene expression changes in the liver of mice treated with benzene

Biomarker Insights

Volumn 2008, Issue 3, 2008, Pages 191-201

  Park, Han Jin ^a   Oh, Jung Hwa ^a   Yoon, Seokjoo ^a   Rana, S V S ^b  

^a Korea Institute of Toxicology   (South Korea)

^b CH CHARAN SINGH UNIVERSITY   (India)

Author keywords

Benzene; Circadian rhythms; Gene expression; Liver; Molecular markers; Pathways

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACETYL COENZYME A ACETYLTRANSFERASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; ASPARTATE AMINOTRANSFERASE; BENZENE; BIOLOGICAL MARKER; CHEMOKINE RECEPTOR CCR5; CLAUDIN 1; CRYPTOCHROME 1; CYCLIN D2; EPIDERMAL GROWTH FACTOR; FATTY ACID SYNTHASE; GLUTATHIONE TRANSFERASE M3; GLYCINE DEHYDROGENASE (DECARBOXYLATING); GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE 2; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 3; MINICHROMOSOME MAINTENANCE PROTEIN 5; PLATELET DERIVED GROWTH FACTOR C; PRESENILIN 2; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SPHINGOSINE KINASE 2; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOTRANSFORMATION; CELL CYCLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DETOXIFICATION; DNA MICROARRAY; DOWN REGULATION; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HISTOPATHOLOGY; LIVER CELL; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RNA ISOLATION; TOXICOGENETICS; UNINDEXED SEQUENCE; UPREGULATION;

MUS;

EID: 41949106953     PISSN: None     EISSN: 11772719     Source Type: Journal    
DOI: 10.4137/bmi.s590     Document Type: Article

References (29)

1. Chen, H. and Eastmond, D.A. 1995. Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice. Carcinogenesis, 16:1963-9.
2. Chen, L., Bi, Y.Y., Tao, N., Wang, H., Xia, Y. and Ma, Q. 2005. cDNA microarray to identify the significance of DNA replication and damage repair genes associated with benzene poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23:248-51.
3. Eisen, M.B., Spellman, P.T., Brown, P.O. and Botstein, D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci., U.S.A. 95: 14863-8.
4. Farris, G.M., Robinson, S.N., Gaido, K.W., Wong, B.A., Wong, V.A., Hahn, W. P. et al. 1997. Benzene-induced hematotoxicity and bone marrow compensation in B6C3F1 mice. Fundam Appl. Toxicol., 36:119-29.
5. Forrest, M.S., Lan, Q., Hubbard, A.E. et al. 2005. Discovqry of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene exposed workers. Environmental Health Perspectives, 113:801-7.
6. Gut, I., Nedelcheva, V., Soucek, P., Stopka, P., Vodicka, P., Gelboin, H.V. et al. 1996. The role of CYP2E1 and 2B.1 in metabolic activation of benzene derivatives. Arch. Toxicol., 71:45-56.
7. Heijne, W.H., Jonker, D., Stierum, R.H., VanOmmen, B. and Groten, J.P. 2005. Toxicogenomic analysis of gene expression changes in rat liver after a 28 day oral benzene exposure. Mutat. Res., 575:85-101.
8. Henderson, R.F. 1996. Species differences in the metabolism of benzene. Environ. Health Perspect., 104, (suppl. 6):1173-5.
9. Kim, E., Kang, B.Y. and Kim, T.S. 2005. Inhibition of interleukin-12 production in mouse macrophages by hydroquinosone, a reactive metabolite of benzene, via suppression of nuclear factor-kappa B. binding activity. Immunol. Lett, 99:24-9.
10. Laskin, D.L., Heck, D.E., Punjabi, C.J. and Laskin, J.D. 1996. Role of nitric oxide in hematosuppression and benzene-induced toxicity. Environ. Health Perspect., 104(suppl 6):1283-7.
11. Lee, E.W. and Garner, C.D. 1991. Effects of benzene on DNA strand breaks in vivo versus benzene metabolite-induced DNA strand breaks in vitro in mouse bone marrow cells. Toxicol. Appl. Pharmacol., 108:497-508.
12. Leung, P.L. and Harrison, R.M. 1998. Evaluation of personal exposure to monoaromatic hydrocarbons. Occup Env. Med., 55:249-55.
13. Minami, K., Saito, T., Narahara, M., Tomita, H., Kato, H., Sugiyama, H., Katoh, M., Nakajima, M. and Yokoi, T. 2005. Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant - administered rats. Toxicol. Sci., 87:296-305.
14. Niculescu, R., Bradford, H.N., Colman, R.W. and Kalf, G.F. 1995. Inhibition of the conversion of pre-interleukins-1 alpha and 1 beta to mature cytokines by p-benzoquinone, a metabolite of benzene. Chem. Biol. Interact., 98:211-22.
15. Rana, S.V.S. and Verma, Y. 2005. Biochemical toxicity of benzene. J. Env. Biol., 26:157-68.
16. Rana, S.V.S., Chaudhary, N. and Verma, Y. 2007. Circadian variation in lipid peroxidation induced by benzene in rat. Indian J. Exp. Biol., 45:253-7.
17. Ross, D. 2000. The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J. Toxicol Environ. Health, A 61:357-72.
18. Smith, M.T., Vermeulen, R., Li, G., Zhang, L., Lan, Q., Hubbard, A.E., Forrest, M.S., McHale, C., Zhao, X., Gunn, L., Shen, M., Rappaport, S.M., Yin, S., Chanock, S. and Rothman, N. 2005. Use of 'Omic' technologies to study humans exposed to benzene. Chem. Biol. Interact., 30:153-4.
19. Snyder, R. and Hedli, C.C. 1996. An overview of benzene metabolism. Environ. Health Perspect., 104 (suppl 6):1165-71.
20. Snyder, R. 2002. Benzene and leukemia. Crit. Rev. Toxicol., 32:155-210.
21. Starek, A., Lepiary, W. and Baran, J. 1990. Susceptibility of rats to benzene during morning and evening. Folia Med. Cracov., 31:279-84.
22. Valentine, J.L., Lee, S.S., Seaton, M.J., Asgharian, B., Farris, G., Corton, J.C. et al. 1996. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol. Appl. Pharmacol., 141:205-13.
23. Wan, J., Badham, H.J. and Winn, L. 2005. The role of c-MYB. in benzene-initiated toxicity. Chem. Biol. Interact., 153-154:171-8.
24. Wang, H., Bi, Y., Tao, N. and Wang, C. 2005. Diferentially expressed genes of cell signal transduction associated with benzene poisoning by cDNA microarray. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23:252-5.
25. Wang, H., Bi, Y., Wang, C., Tao, N., Xia, Y. and Zhang, L. 2005. cDNA microarray and cluster analysis to identify the significance of immune genes associated with benzene poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23(4):260-2.
26. Waters, M.D., Olden, K. and Tennant, R.W. 2003. Toxicogenomic approach for assessing toxicant-related disease. Mutat. Res., 544:415-24.
27. Xia, Y., Zhang, H.X, Bi, Y.Y., Chen, X.H., Zhao, Z.W. and Wang, H. 2005. Analysis on tumor related gene expression profiles in benzene poisoning using c-DNA microarray. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 23:256-9.
28. Yoon, B.I., Hirabayshi, Y., Kawasaki, Y., Kodama, Y., Kaneko, T., Kim, D.Y. et al. 2001b. Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM). Exp. Hematol., 29:278-85.
29. Yoon, B.I., Li, G.X., Kitada, K. and Kawasaki, Y. 2003. Mechanism of benzene induced hematotoxicity and leukemogenicity cDNA microarray analysises using mouse bone marrow tissue, Environ. Health Perspect., 111:1411-20.