Reversible and irreversible membrane fouling during in-line microfiltration of concentrated protein solutions

Journal of Membrane Science

Volumn 315, Issue 1-2, 2008, Pages 1-10

  Kanani, Dharmesh M ^a   Sun, Xinghua ^a   Ghosh, Raja ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Constant flux; Dead end filtration; Fouling; In line filter; Membrane; Microfiltration; Protein

Indexed keywords

CONCENTRATION (PROCESS); POLARIZATION; PRESSURE EFFECTS; PROTEINS;

CONSTANT FLUX; DEAD-END FILTRATION; IN-LINE FILTER;

MICROFILTRATION;

BOVINE SERUM ALBUMIN;

CONCENTRATION (PROCESS); MICROFILTRATION; POLARIZATION; PRESSURE EFFECTS; PROTEINS;

ARTICLE; CONFOCAL LASER MICROSCOPY; GEL PERMEATION CHROMATOGRAPHY; MEMBRANE; MICROFILTRATION; POLARIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION;

EID: 41949105585     PISSN: 03767388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.memsci.2008.01.053     Document Type: Article

References (26)

1. Zeman L.J., and Zydney A.L. Microfiltration and Ultrafiltration Principles and Applications (1996), Marcel Dekker, New York
2. A.S. Chandavarkar, C.L. Cooney, Mathematical modeling of flux decline caused by protein aggregation, ACS National Meeting, Washington DC, August 1990, cited from S.T. Kelly, W.S. Opong, A.L. Zydney, The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration, J. Membr. Sci., 80 (1993) 175.
3. Meireles M., Aimar P., and Sanchez V. Albumin denaturation during ultrafiltration: effects of operating conditions and consequences on membrane fouling. Biotechnol. Bioeng. 38 (1991) 528
4. Cheryan M. Ultrafiltration and Microfiltration Handbook (1998), Technomic, Lancaster
5. Bowen W.R., and Gan Q. Properties of microfiltration membranes: flux loss during constant pressure permeation of bovine serum albumin. Biotechnol. Bioeng. 38 (1991) 688
6. Boyd R.F., and Zydney A.L. Analysis of protein fouling during ultrafiltration using a two-layer membrane model. Biotechnol. Bioeng. 59 (1998) 451
7. Marshall A.D., Munro P.A., and Tragardh G. The effect of protein fouling in microfiltration and ultrafiltration on permeate flux, protein retention and selectivity: a literature review. Desalination 91 (1993) 65
8. Opong W.S., and Zydney A.L. Hydraulic permeability of protein layers deposited during ultrafiltration. J. Colloid Interf. Sci. 142 (1991) 41
9. Tracey E.M., and Davis R.H. Protein fouling of track-etched polycarbonate microfiltration membranes. J. Colloid Interf. Sci. 167 (1994) 104
10. Ho C.C., and Zydney A.L. Effect of membrane morphology on the initial rate of protein fouling during microfiltration. J. Membr. Sci. 155 (1999) 261
11. Ho C.C., and Zydney A.L. Theoretical analysis of the effect of membrane morphology on fouling during microfiltration. Sep. Sci. Technol. 34 (1999) 2461
12. Ho C.C., and Zydney A.L. A combined pore blockage and cake filtration model for protein fouling during microfiltration. J. Colloid Interf. Sci. 232 (2000) 389
13. Shiau J.S., Tang C.H., Lin T.Y., and Wang D.M. A model for resistance growth during protein microfiltration. Sep. Sci. Technol. 38 (2003) 917
14. Bolton G., LaCasse D., and Kuriyel R. Combined models of membrane fouling: development and application to microfiltration and ultrafiltration of biological fluids. J. Membr. Sci. 277 (2006) 75
15. Orsello C.D., Li W., and Ho C.C. A three mechanism model to describe fouling of microfiltration membranes. J. Membr. Sci. 280 (2006) 856
16. Ho C.C., and Zydney A.L. Effect of membrane morphology on system capacity during normal flow microfiltration. Biotechnol. Bioeng. 83 (2003) 537
17. Iritani E., Mukai Y., Tanaka Y., and Murase T. Flux decline behavior in dead-end microfiltration of protein solutions. J. Membr. Sci. 103 (1995) 181
18. Bowen W.R., Calvo J.I., and Hernandez A. Steps of membrane blocking in flux decline during protein microfiltration. J. Membr. Sci. 101 (1995) 153
19. Ho C.C., and Zydney A.L. Transmembrane pressure profiles during constant flux microfiltration of bovine serum albumin. J. Membr. Sci. 209 (2002) 363
20. Chen V. Performance of partially permeable microfiltration membranes under low fouling conditions. J. Membr. Sci. 147 (1998) 265
21. Kelly S.T., Opong W.S., and Zydney A.L. The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration. J. Membr. Sci. 80 (1993) 175
22. Kelly S.T., and Zydney A.L. Mechanisms for BSA fouling during microfiltration. J. Membr. Sci. 107 (1995) 115
23. Hlavacek M., and Bouchet F. Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions. J. Membr. Sci. 82 (1993) 285
24. Palecek S.P., Mochizuki S., and Zydney A.L. Effect of ionic environment on BSA filtration and the properties of BSA deposits. Desalination 90 (1993) 147
25. Reichert U., Linden T., Belfort G., Kula M.-R., and Thommes J. Visualising protein adsorption to ion-exchange membranes by confocal microscopy. J. Membr. Sci. 199 (2002) 161
26. Ferrando M., Rozek A., Zator M., Lopez F., and Guell C. An approach to membrane fouling characterization by confocal scanning laser microscopy. J. Membr. Sci. 250 (2005) 283