Serologic and molecular profile of anti-HBc-positive blood bank donors in an area of low endemicity for HBV

Digestive Diseases and Sciences

Volumn 53, Issue 5, 2008, Pages 1370-1374

  Kupski, Carlos ^a,b   Träsel, Felipe R ^a   Mazzoleni, Felipe ^a   Winckler, Marco A ^a   Bender, Ana Ligia ^a   Machado, Denise C ^a   Schmitt, Virgínia M ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b NONE   (Brazil)

Author keywords

Blood donation; HBV; HBV DNA; Polymerase chain reaction; Serological markers

Indexed keywords

HEPATITIS B ANTIBODY; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

ANTIBODY TITER; ARTICLE; BLOOD BANK; BLOOD DONOR; ENDEMIC DISEASE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROLOGY;

BIOLOGICAL MARKERS; BLOOD BANKS; BLOOD DONORS; BLOOD TRANSFUSION; BRAZIL; CHI-SQUARE DISTRIBUTION; DNA, VIRAL; FEMALE; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MALE; POLYMERASE CHAIN REACTION; SEROEPIDEMIOLOGIC STUDIES;

EID: 41949105316     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-0019-7     Document Type: Article

References (20)

1. Lee WM (1997) Hepatitis B virus infection. N Engl J Med 337:1733-1745
2. Lin KW, Kirchner JT (2004) Hepatitis B. Am Fam Physician 69:75-82
3. Lok AS, McMahon BJ (2001) Chronic hepatitis B. Hepatology 34:1225-1241
4. Zoulim F, Tong S, Trepo C (2004) Study of HBV replication capacity in relation to sequence variation in the precore and core promoter regions. Methods Mol Med 95:235-246
5. Alter MJ, Hadler SC, Margolis HS, Alexander WJ, Hu PY, Judson FN, Mares A et al (1990) The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies. JAMA 263:1218-1222
6. Hoofnagle JH, Shafritz DA, Popper H (1987) Chronic type B hepatitis and the "healthy" HBsAg carrier state. Hepatology 7:758-763
7. Silveira TR, da Fonseca JC, Rivera L, Fay OH, Tapia R, Santos JI, Urdeneta E et al (1999) Hepatitis B seroprevalence in Latin America. Rev Panam Salud Publica 6:378-383
8. Brechot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Brechot P (2001) Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"? Hepatology 34:194-203
9. Draelos M, Morgan T, Schifman RB, Sampliner RE (1987) Significance of isolated antibody to hepatitis B core antigen determined by immune response to hepatitis B vaccination. JAMA 258:1193-1195
10. Schifman RB, Rivers SL, Sampliner RE, Krammes JE (1993) Significance of isolated hepatitis B core antibody in blood donors. Arch Intern Med 153:2261-2266
11. Kaneko S, Miller RH, Di Bisceglie AM, Feinstone SM, Hoofnagle JH, Purcell RH (1990) Detection of hepatitis B virus DNA in serum by polymerase chain reaction. Application for clinical diagnosis. Gastroenterology 99:799-804
12. Malter JS, Gerber MA (1991) The polymerase chain reaction for hepatitis B virus DNA. Hepatology 13:188-190
13. Reiche EM, Vogler IH, Morimoto HK, Bortoliero AL, Matsuo T, Yuahasi KK, Cancian SJ et al (2003) Evaluation of surrogate markers for human immunodeficiency virus infection among blood donors at the blood bank of "Hospital Universitario Regional Norte do Parana", Londrina, PR, Brazil. Rev Inst Med Trop Sao Paulo 45:23-27
14. Mosley JW, Stevens CE, Aach RD, Hollinger FB, Mimms LT, Solomon LR, Barbosa LH et al (1995) Donor screening for antibody to hepatitis B core antigen and hepatitis B virus infection in transfusion recipients. Transfusion 35:5-12
15. Kuhns MC, Kleinman SH, McNamara AL, Rawal B, Glynn S, Busch MP (2004) Lack of correlation between HBsAg and HBV DNA levels in blood donors who test positive for HBsAg and anti-HBc: implications for future HBV screening policy. Transfusion 44:1332-1339
16. Sambrook JRD (2001) Preparation and analysis of eukaryotic genomic DNA. Molecular cloning - a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory Press, New York
17. McMillan JS, Bowden DS, Angus PW, McCaughan GW, Locarnini SA (1996) Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation. Hepatology 24:1371-1378
18. Sherlock S (1989) Virus hepatitis B, A, non-A, non-B. J Hepatol 8:254-258
19. Zervou EK, Dalekos GN, Boumba DS, Tsianos EV (2001) Value of anti-HBc screening of blood donors for prevention of HBV infection: results of a 3-year prospective study in Northwestern Greece. Transfusion 41:652-658
20. Roque-Afonso AM, Feray C, Samuel D, Simoneau D, Roche B, Emile JF, Gigou M et al (2002) Antibodies to hepatitis B surface antigen prevent viral reactivation in recipients of liver grafts from anti-HBC positive donors. Gut 50:95-99