Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine

Journal of Inorganic Biochemistry

Volumn 102, Issue 5-6, 2008, Pages 1077-1089

  Halámiková, Anna ^a   Heringová, Pavla ^a   Kašpárková, Jana ^a   Intini, Francesco P ^b   Natile, Giovanni ^b   Nemirovski, Alina ^c   Gibson, Dan ^c   Brabec, Viktor ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b UNIVERSITY OF BARI   (Italy)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Adamantylamine ligand; Antitumor platinum; Cytotoxicity; DNA binding; Mutagenicity

Indexed keywords

1 ADAMANTYLAMINE; AMINE; CISPLATIN; DNA; GLUTATHIONE; MUTANT PROTEIN; PLATINUM; SULFUR; THIOUREA; TRANSPLATIN; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA BINDING; DNA CROSS LINKING; DNA SUPERCOILING; DRUG MECHANISM; DRUG SYNTHESIS; GENE TARGETING; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MUTAGENESIS;

AMANTADINE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; DNA ADDUCTS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENS; ORGANOPLATINUM COMPOUNDS;

EID: 41949095467     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2007.12.015     Document Type: Article

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