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Volumn 9, Issue 5, 2008, Pages 687-700

Antiretroviral regimens for treatment-experienced patients with HIV-1 infection

Author keywords

Antiretrovirals; HIV; Resistance

Indexed keywords

AMPRENAVIR PHOSPHATE; ANTIRETROVIRUS AGENT; ATAZANAVIR; DARUNAVIR; DIDANOSINE; ENFUVIRTIDE; ETRAVIRINE; INTEGRASE INHIBITOR; LOPINAVIR PLUS RITONAVIR; MARAVIROC; PLACEBO; PROTEINASE INHIBITOR; RALTEGRAVIR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; TIPRANAVIR; VICRIVIROC; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

EID: 41949089788     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.9.5.687     Document Type: Review
Times cited : (7)

References (55)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998;338:853-60
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 21844462147 scopus 로고    scopus 로고
    • Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
    • Zaccarelli M, Tozzi V, Lorenzini P, et al. Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients. AIDS 2005;19:1081-9
    • (2005) AIDS , vol.19 , pp. 1081-1089
    • Zaccarelli, M.1    Tozzi, V.2    Lorenzini, P.3
  • 3
    • 3042740596 scopus 로고    scopus 로고
    • Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
    • Ledergerber B, Lundgren JD, Walker AS, et al. Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. Lancet 2004;364:51-62
    • (2004) Lancet , vol.364 , pp. 51-62
    • Ledergerber, B.1    Lundgren, J.D.2    Walker, A.S.3
  • 4
    • 33747122666 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel
    • Hammer SM, Saag MS, Schechter M, et al. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel. JAMA 2006;296:827-43
    • (2006) JAMA , vol.296 , pp. 827-843
    • Hammer, S.M.1    Saag, M.S.2    Schechter, M.3
  • 5
    • 42549095665 scopus 로고    scopus 로고
    • Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents, December 1. Available from:, Last accessed 29 February 2008
    • Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents, 2007 December 1. Available from: http://aidsinfo.nik.gov [Last accessed 29 February 2008]
    • (2007)
  • 6
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari JP, Henry K, O'Hearn M, et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N Engl J Med 2003;348:2175-85
    • (2003) N Engl J Med , vol.348 , pp. 2175-2185
    • Lalezari, J.P.1    Henry, K.2    O'Hearn, M.3
  • 7
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A, Clotet B, Cooper D, et al. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N Engl J Med 2003;348:2186-95
    • (2003) N Engl J Med , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3
  • 8
    • 33746576313 scopus 로고    scopus 로고
    • Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials
    • Hicks CB, Cahn P, Cooper DA, et al. Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials. Lancet 2006;368:466-75
    • (2006) Lancet , vol.368 , pp. 466-475
    • Hicks, C.B.1    Cahn, P.2    Cooper, D.A.3
  • 9
    • 33847041109 scopus 로고    scopus 로고
    • Efficacy and safety of TMC114/ ritonavir in treatment-experienced HIV patients: 24-week results of POWER
    • Katlama C, Esposito R, Gatell JM, et al. Efficacy and safety of TMC114/ ritonavir in treatment-experienced HIV patients: 24-week results of POWER. AIDS 2007;21:395-402
    • (2007) AIDS , vol.21 , pp. 395-402
    • Katlama, C.1    Esposito, R.2    Gatell, J.M.3
  • 10
    • 34047207229 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
    • Cloret B, Bellos N, Molina JM, et al. Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet 2007;369:1169-78
    • (2007) Lancet , vol.369 , pp. 1169-1178
    • Cloret, B.1    Bellos, N.2    Molina, J.M.3
  • 11
    • 34548212545 scopus 로고    scopus 로고
    • Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3
    • Molina JM, Cohen C, Katlama C, et al. Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3. J Acquir Immune Defic Syndr 2007;46:24-31
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 24-31
    • Molina, J.M.1    Cohen, C.2    Katlama, C.3
  • 12
    • 0037626084 scopus 로고    scopus 로고
    • Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs
    • Katzenstein DA, Bosch RJ, Hellmann N, et al. Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs. AIDS 2003;17:821-30
    • (2003) AIDS , vol.17 , pp. 821-830
    • Katzenstein, D.A.1    Bosch, R.J.2    Hellmann, N.3
  • 13
    • 0344593433 scopus 로고    scopus 로고
    • The relationship between baseline HIV drug resistance and response to antiretroviral therapy: Re-analysis of retrospective and prospective studies using a standardized data analysis plan
    • DeGruttola V, Dix L, D'Aquila RT, et al. The relationship between baseline HIV drug resistance and response to antiretroviral therapy: re-analysis of retrospective and prospective studies using a standardized data analysis plan. Antiviral Ther 2000;5:41-8
    • (2000) Antiviral Ther , vol.5 , pp. 41-48
    • DeGruttola, V.1    Dix, L.2    D'Aquila, R.T.3
  • 14
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Madruga JV, Cahn P, Grinsrztejn B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007;370:29-38
    • (2007) Lancet , vol.370 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsrztejn, B.3
  • 15
    • 34347354196 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Lazzarin A, Campbell T, Clotet B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007;370:39-48
    • (2007) Lancet , vol.370 , pp. 39-48
    • Lazzarin, A.1    Campbell, T.2    Clotet, B.3
  • 16
    • 34248177765 scopus 로고    scopus 로고
    • Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
    • abstract #105aLB, Feb 25, 28; Los Angeles, CA
    • Cooper D, Gatell J, Rockstroh J, et al. Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus [abstract #105aLB]. 14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 25 - 28; Los Angeles, CA
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Cooper, D.1    Gatell, J.2    Rockstroh, J.3
  • 17
    • 34248205567 scopus 로고    scopus 로고
    • Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
    • abstract #105bLB, Feb 25, 28; Los Angeles, CA
    • Steigbigel R, Kumar P, Eron J, et al. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus [abstract #105bLB]. 14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 25 - 28; Los Angeles, CA
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Steigbigel, R.1    Kumar, P.2    Eron, J.3
  • 18
    • 34249075565 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results
    • abstract #104aLB, Feb 25, 28; Los Angeles, CA
    • Nelson M, Fätkenheuer G, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results [abstract #104aLB]. 14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 25 - 28; Los Angeles, CA
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Nelson, M.1    Fätkenheuer, G.2    Konourina, I.3
  • 19
    • 34249089383 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/ 3 study in the US and Canada
    • abstract #104bLB, Feb 25, 28; Los Angeles, CA
    • Lalezari J, Goodrich J, DeJesus E, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/ 3 study in the US and Canada [abstract #104bLB]. 14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 25 - 28; Los Angeles, CA
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Lalezari, J.1    Goodrich, J.2    DeJesus, E.3
  • 20
    • 34347379935 scopus 로고    scopus 로고
    • Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211
    • Gulick RM, Su Z, Flexner C, et al. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211. J Infect Dis 2007;196:304-12
    • (2007) J Infect Dis , vol.196 , pp. 304-312
    • Gulick, R.M.1    Su, Z.2    Flexner, C.3
  • 21
    • 27144549662 scopus 로고    scopus 로고
    • Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    • Deeks SG, Hoh R, Neilands TB, et al. Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J Infect Dis 2005;192:1537-44
    • (2005) J Infect Dis , vol.192 , pp. 1537-1544
    • Deeks, S.G.1    Hoh, R.2    Neilands, T.B.3
  • 22
    • 0032492398 scopus 로고    scopus 로고
    • CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART)
    • Kaufmann D, Pantaleo G, Sudre P, et al. CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART). Lancet 1998;351:723-4
    • (1998) Lancet , vol.351 , pp. 723-724
    • Kaufmann, D.1    Pantaleo, G.2    Sudre, P.3
  • 23
    • 0042431969 scopus 로고    scopus 로고
    • Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus
    • Lawrence J, Mayers DL, Hullsiek KH, et al. Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus. N Engl J Med 2003;349:837-46
    • (2003) N Engl J Med , vol.349 , pp. 837-846
    • Lawrence, J.1    Mayers, D.L.2    Hullsiek, K.H.3
  • 24
    • 33751515147 scopus 로고    scopus 로고
    • Group Strategies for Management of Antiretroviral Therapy (SMART) Study. CD4+ count-guided interruption of antiretroviral treatment
    • El-Sadr WM, Lundgren JD, et al. Group Strategies for Management of Antiretroviral Therapy (SMART) Study. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med 2006;355:2283-96
    • (2006) N Engl J Med , vol.355 , pp. 2283-2296
    • El-Sadr, W.M.1    Lundgren, J.D.2
  • 25
    • 21844450214 scopus 로고    scopus 로고
    • Antiviral activity of lamivudine in salvage therapy for multidrug-resistant HIV-1 infection
    • Campbell TB, Shulman NS, Johnson SC, et al. Antiviral activity of lamivudine in salvage therapy for multidrug-resistant HIV-1 infection. Clin Infect Dis 2005;41:236-42
    • (2005) Clin Infect Dis , vol.41 , pp. 236-242
    • Campbell, T.B.1    Shulman, N.S.2    Johnson, S.C.3
  • 26
    • 33750731028 scopus 로고    scopus 로고
    • Rate of viral evolution and risk of losing future drug options in heavily pretreated, HIV-infected patients who continue to receive a stable, partially suppressive treatment regimen
    • Hatano H, Hunt P, Weidler J, et al. Rate of viral evolution and risk of losing future drug options in heavily pretreated, HIV-infected patients who continue to receive a stable, partially suppressive treatment regimen. Clin Infect Dis 2006;43:1329-36
    • (2006) Clin Infect Dis , vol.43 , pp. 1329-1336
    • Hatano, H.1    Hunt, P.2    Weidler, J.3
  • 27
    • 0037684348 scopus 로고    scopus 로고
    • The Context Study. Efficacy and safety of GW433908/RTV in PI-experienced subjects with virologic failure (24 week results)
    • abstract 178, Feb 9, 14; Boston, MA
    • DeJesus E, LaMarca A, Sension M, et al.; The Context Study. Efficacy and safety of GW433908/RTV in PI-experienced subjects with virologic failure (24 week results) [abstract 178]. 10th Conference on Retroviruses and Opportunistic Infections; 2003 Feb 9 - 14; Boston, MA
    • (2003) 10th Conference on Retroviruses and Opportunistic Infections
    • DeJesus, E.1    LaMarca, A.2    Sension, M.3
  • 28
    • 3843151487 scopus 로고    scopus 로고
    • SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients
    • Gathe JC Jr, Ive P, Wood R, et al. SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS 2004;18:1529-37
    • (2004) AIDS , vol.18 , pp. 1529-1537
    • Gathe Jr, J.C.1    Ive, P.2    Wood, R.3
  • 29
    • 1642465026 scopus 로고    scopus 로고
    • Dose-ranging randomized, clinical trial of atazanavir with lamivudine and stavudine in antiretroviral-naive subjects: 48-week results
    • Murphy RL, Sanne I, Cahn P, et al. Dose-ranging randomized, clinical trial of atazanavir with lamivudine and stavudine in antiretroviral-naive subjects: 48-week results. AIDS 2003;17:2603-14
    • (2003) AIDS , vol.17 , pp. 2603-2614
    • Murphy, R.L.1    Sanne, I.2    Cahn, P.3
  • 30
    • 3342924014 scopus 로고    scopus 로고
    • Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy fur patients infected with HIV
    • Squires K, Lazzarin A, Gatell JM, et al. Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy fur patients infected with HIV. J Acquir Immune Defic Syndr 2004;36:1011-9
    • (2004) J Acquir Immune Defic Syndr , vol.36 , pp. 1011-1019
    • Squires, K.1    Lazzarin, A.2    Gatell, J.M.3
  • 31
    • 27144482749 scopus 로고    scopus 로고
    • Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: A randomized multinational trial
    • Cohen C, Nieto-Cisneros L, Zala C, et al. Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial. Curr Med Res Opin 2005;21:1683-92
    • (2005) Curr Med Res Opin , vol.21 , pp. 1683-1692
    • Cohen, C.1    Nieto-Cisneros, L.2    Zala, C.3
  • 32
    • 17844387166 scopus 로고    scopus 로고
    • Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures
    • Johnson M, Grinsztejn B, Rodriguez C, et al. Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures. AIDS 2005;19:685-94
    • (2005) AIDS , vol.19 , pp. 685-694
    • Johnson, M.1    Grinsztejn, B.2    Rodriguez, C.3
  • 33
    • 33646744190 scopus 로고    scopus 로고
    • 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures
    • Johnson M, Grinsztejn B, Rodriguez C, et al. 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures. AIDS 2006;20:711-8
    • (2006) AIDS , vol.20 , pp. 711-718
    • Johnson, M.1    Grinsztejn, B.2    Rodriguez, C.3
  • 34
    • 33646708083 scopus 로고    scopus 로고
    • Effect of baseline protease genotype and phenotype on HIV response to atazanavir/ritonavir in treatment-experienced patients
    • Naeger LK, Struble KA. Effect of baseline protease genotype and phenotype on HIV response to atazanavir/ritonavir in treatment-experienced patients. AIDS 2006;20:847-53
    • (2006) AIDS , vol.20 , pp. 847-853
    • Naeger, L.K.1    Struble, K.A.2
  • 35
    • 33845925741 scopus 로고    scopus 로고
    • Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients
    • Naeger LK, Struble KA. Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients. AIDS 2007;21:179-85
    • (2007) AIDS , vol.21 , pp. 179-185
    • Naeger, L.K.1    Struble, K.A.2
  • 36
    • 34247869104 scopus 로고    scopus 로고
    • Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials
    • Hill A, Moyle G. Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials. HIV Med 2007;8:259-64
    • (2007) HIV Med , vol.8 , pp. 259-264
    • Hill, A.1    Moyle, G.2
  • 37
    • 34347329093 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
    • Madruga JV, Berger D, McMurchie M, et al. Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial. Lancet 2007;370:49-58
    • (2007) Lancet , vol.370 , pp. 49-58
    • Madruga, J.V.1    Berger, D.2    McMurchie, M.3
  • 38
    • 3142760542 scopus 로고    scopus 로고
    • Low-frequency NNRTI-resistant variants contribute to failure of efavirenz-containing regimens
    • abstract 35, Feb 8, 11; San Francisco, CA
    • Mellors J, Palmer S, Nissley D, et al. Low-frequency NNRTI-resistant variants contribute to failure of efavirenz-containing regimens [abstract 35]. 11th Conference on Retroviruses and Opportunistic Infections; 2004 Feb 8 - 11; San Francisco, CA
    • (2004) 11th Conference on Retroviruses and Opportunistic Infections
    • Mellors, J.1    Palmer, S.2    Nissley, D.3
  • 39
    • 26444595584 scopus 로고    scopus 로고
    • TMC125 displays a high genetic barrier to the development of resistance: Evidence from in vitro selection experiments
    • Vingerhoets J, Azijn H, Fransen E, et al. TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments. J Virol 2005;79:12773-82
    • (2005) J Virol , vol.79 , pp. 12773-12782
    • Vingerhoets, J.1    Azijn, H.2    Fransen, E.3
  • 40
    • 42549107504 scopus 로고    scopus 로고
    • DUET-2: 24 week results of a phase III randomized double-blind trial to evaluate the efficacy and safety af TMC125 versus placebo in 591 treatment-experienced HIV-1 infected patients [abstract WESS204:2]
    • Jul 22, 25; Sydney, Australia
    • Katlama C, Campbell T, Clotet B, et al. DUET-2: 24 week results of a phase III randomized double-blind trial to evaluate the efficacy and safety af TMC125 versus placebo in 591 treatment-experienced HIV-1 infected patients [abstract WESS204:2]. 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; 2007 Jul 22 - 25; Sydney, Australia
    • (2007) 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
    • Katlama, C.1    Campbell, T.2    Clotet, B.3
  • 41
    • 42549140294 scopus 로고    scopus 로고
    • Impact of baseline NNRTI mutations on the virological response to TMC125 in the Phase III clinical trials DUET-1 and DUET-2 [abstract 32]
    • Jun 12, 16; Barbados, West Indies
    • Vingerhoets J, Buelens A, Peeters M, et al. Impact of baseline NNRTI mutations on the virological response to TMC125 in the Phase III clinical trials DUET-1 and DUET-2 [abstract 32]. 16th International HIV Drug Resistance Workshop; 2007 Jun 12 - 16; Barbados, West Indies
    • (2007) 16th International HIV Drug Resistance Workshop
    • Vingerhoets, J.1    Buelens, A.2    Peeters, M.3
  • 42
    • 33745095614 scopus 로고    scopus 로고
    • Enfuvirtide plasma levels and injection site reactions using a needle-free gas-powered injection system (Biojector)
    • Harris M, Joy R, Larsen G, et al. Enfuvirtide plasma levels and injection site reactions using a needle-free gas-powered injection system (Biojector). AIDS 2006;20:719-23
    • (2006) AIDS , vol.20 , pp. 719-723
    • Harris, M.1    Joy, R.2    Larsen, G.3
  • 43
    • 33745081840 scopus 로고    scopus 로고
    • Transient neuropathy after needle-free injection outside of recommended sites
    • Harris M, Larsen G, Valyi M, et al. Transient neuropathy after needle-free injection outside of recommended sites. AIDS 2006;20:784-5
    • (2006) AIDS , vol.20 , pp. 784-785
    • Harris, M.1    Larsen, G.2    Valyi, M.3
  • 45
    • 34548235885 scopus 로고    scopus 로고
    • Baseline HIV-1 co-receptor tropism predicts disease progression
    • Daar ES, Kesler KL, Petropoulos CJ, et al. Baseline HIV-1 co-receptor tropism predicts disease progression. Clin Infect Dis 2007;45:643-9
    • (2007) Clin Infect Dis , vol.45 , pp. 643-649
    • Daar, E.S.1    Kesler, K.L.2    Petropoulos, C.J.3
  • 46
    • 14844333093 scopus 로고    scopus 로고
    • Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection
    • Moyle GJ, Wildfire A, Mandalia S, et al. Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J Infect Dis 2005;191:866-72
    • (2005) J Infect Dis , vol.191 , pp. 866-872
    • Moyle, G.J.1    Wildfire, A.2    Mandalia, S.3
  • 47
    • 33749039498 scopus 로고    scopus 로고
    • Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia
    • Hunt PW, Harrigan PR, Huang W, et al. Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. J Infect Dis 2006;194:926-30
    • (2006) J Infect Dis , vol.194 , pp. 926-930
    • Hunt, P.W.1    Harrigan, P.R.2    Huang, W.3
  • 48
    • 35048870707 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc in antiretroviral-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1
    • Sept 17, 20; Chicago, IL
    • Lalezari J, Goodrich J, DeJesus E, et al. Efficacy and safety of maraviroc in antiretroviral-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2007 Sept 17 - 20; Chicago, IL
    • (2007) 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Lalezari, J.1    Goodrich, J.2    DeJesus, E.3
  • 49
    • 33749839996 scopus 로고    scopus 로고
    • Safety and efficacy of MARAVIROC (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial
    • abstract THLB0215, Aug 13, 18; Toronto, Canada
    • Mayer H, van Dder Ryst E, Saag M, et al. Safety and efficacy of MARAVIROC (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial [abstract THLB0215]. XVI International AIDS Conference; 2006 Aug 13 - 18; Toronto, Canada
    • (2006) XVI International AIDS Conference
    • Mayer, H.1    van Dder Ryst, E.2    Saag, M.3
  • 50
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M, Lewis M, Whitcomb J, et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 2006;80:4909-20
    • (2006) J Virol , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 51
    • 34548277206 scopus 로고    scopus 로고
    • CXCR4-using virus detected in patients receiving maraviroc in the phase III studies MOTIVATE 1 and 2 originates from a pre-existing minority of CXCR4-using virus
    • abstract 56, Jun 12, 16; Barbados, West Indies
    • Lewis M, Simpson P, Fransen S, et al. CXCR4-using virus detected in patients receiving maraviroc in the phase III studies MOTIVATE 1 and 2 originates from a pre-existing minority of CXCR4-using virus [abstract 56]. 16th International HIV Drug Resistance Workshop; 2007 Jun 12 - 16; Barbados, West Indies
    • (2007) 16th International HIV Drug Resistance Workshop
    • Lewis, M.1    Simpson, P.2    Fransen, S.3
  • 52
    • 40649110404 scopus 로고    scopus 로고
    • Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2
    • abstract 10, Jun 12, 16; Barbados, West Indies
    • Mori J, Mosley M, Lewis M, et al. Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2 [abstract 10]. 16th International HIV Drug Resistance Workshop; 2007 Jun 12 - 16; Barbados, West Indies
    • (2007) 16th International HIV Drug Resistance Workshop
    • Mori, J.1    Mosley, M.2    Lewis, M.3
  • 53
    • 39149133656 scopus 로고    scopus 로고
    • Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile Virus infection: A meta-analysis of 4 cohorts in the US epidemic
    • Lim JK, Louie CY, Glaser C, et al. Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile Virus infection: a meta-analysis of 4 cohorts in the US epidemic. J Infect Dis 2008;197:262-5
    • (2008) J Infect Dis , vol.197 , pp. 262-265
    • Lim, J.K.1    Louie, C.Y.2    Glaser, C.3
  • 54
    • 33846027213 scopus 로고    scopus 로고
    • ACTG 5211: Phase II study of the safety and efficacy of vicriviroc in HIV-infected treatment-experienced subjects
    • abstract ThLB0217, Aug 13, 18; Toronto, Canada
    • Gulick R, Su Z, Flexner C, et al. ACTG 5211: phase II study of the safety and efficacy of vicriviroc in HIV-infected treatment-experienced subjects [abstract ThLB0217]. XVI International AIDS Conference; 2006 Aug 13 - 18; Toronto, Canada
    • (2006) XVI International AIDS Conference
    • Gulick, R.1    Su, Z.2    Flexner, C.3
  • 55
    • 35648950291 scopus 로고    scopus 로고
    • Resistance to the HIV integrase inhibitor raltegravir: Analysis of Protocol 005, a phase 2 study in patients with triple-class resistant HIV-1 infection
    • abstract 8, Jun 12, 16; Barbados, West Indies
    • Hazuda DJ, Miller MD, Nguyen BY, Zhao J. Resistance to the HIV integrase inhibitor raltegravir: analysis of Protocol 005, a phase 2 study in patients with triple-class resistant HIV-1 infection [abstract 8]. 16th International HIV Drug Resistance Workshop; 2007 Jun 12 - 16; Barbados, West Indies
    • (2007) 16th International HIV Drug Resistance Workshop
    • Hazuda, D.J.1    Miller, M.D.2    Nguyen, B.Y.3    Zhao, J.4


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