Dressings and topical agents for arterial leg ulcers

Cochrane Database of Systematic Reviews

Volumn , Issue 1, 2007, Pages

  Nelson, E Andrea ^a   Bradley, M D ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NONE

Author keywords

*Occlusive dressings; Administration, topical; Arteries; Humans; Ketanserin *administration dosage ; Leg ulcer *therapy ; Ointments; Platelet aggregation inhibitors *administration dosage ; Wound healing

Indexed keywords

CHAMOMILE; GRAPE SEED EXTRACT; KETANSERIN; LAVENDER OIL;

ATHEROSCLEROSIS; COMPRESSION BANDAGE; HUMAN; INTERMITTENT CLAUDICATION; ISCHEMIA; LEG ULCER; REVIEW; ULCER HEALING; WOUND DRESSING; WOUND INFECTION;

EID: 41949087881     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD001836.pub2     Document Type: Review

References (94)

1. Hartman 2002 {published data only} Hartman D, Coetzee JC. Two US practitioners' experience of using essential oils for wound care. Journal of Wound Care 2002;11(8):317-20.
2. Rooman 1991 {published data only} Rooman RP, Janssen H. Ketanserin promotes wound healing: clinical and preclinical results. Progress in Clinical and Biological Research 1991;365:115-28. [MEDLINE: 91319804].
3. Altman 1976 Altman MA, Richter IH, Kaplan LH. Use of an aqueous triple iodine solution in the treatment of chronic leg ulcers and gangrene. Angiology 1976;27(3):181-7. [MEDLINE: 88161694].
4. Alvarez 2003 Alvarez OM, Rogers RS, Booker JG, Patel M. Effect of noncontact normothermic wound therapy on the healing of neuropathic (diabetic) foot ulcers: an interim analysis of 20 patients. Journal of Foot & Ankle Surgery 2003;42(1):30-5.
5. Amione 2005 Amione P, Ricci E, Topo F, Izzo L, Pirovano R, Rega V, et al.Comparison of Allevyn Adhesive and Biatain Adhesive in the management of pressure ulcers. Journal of Wound Care 2005;14(8):365-70.
6. Andersen 2002 Andersen KE, Franken CPM, Gad P, Larsen AM, Larsen JR, van Neer PAFA, et al.A randomized, controlled study to compare the effectiveness of two foam dressings in the management of lower leg ulcers. Ostomy Wound Management 2002;48(8):34-41.
7. Armstrong 1997 Armstrong SH, Ruckley CV. Use of a fibrous dressing in exuding leg ulcers. Journal of Wound Care 1997;6(7):322-4. [MEDLINE: 97466403].
8. Banks 1997 Banks V, Bale S, Harding K, Harding EF. Evaluation of a new polyurethane foam dressing. Journal of Wound Care 1997;6(6):266-9. [MEDLINE: 97419756].
9. Bayram 2005 Bayram Y, Deveci M, Imirzalioglu N, Soysal Y, Sengezer M. The cell based dressing with living allogenic keratinocytes in the treatment of foot ulcers: a case study. British Journal of Plastic Surgery 2005;58(7):988-96.
10. Beckert 2006 Beckert S, Warnecke J, Zelenkova H, Kovnerystyy O, Stege H, Cholcha, et al.Efficacy of topical pale sulfonated shale oil in the treatment of venous leg ulcers: a randomized, controlled, multicenter study. Journal of Vascular Surgery 2006 Jan;43(1):94-100.
11. Biland 1985 Biland L, Hurlimann F, Goor W, Korner WF, Kundig A, Madar G, et al.Treatment of venous ulcers. A multi-center randomized double-blind study. Vasa 1985;14(4):383-9. [MEDLINE: 86072778].
12. Boxer 1969 Boxer AM, Gottesman N, Bernstein H, Mandl I. Debridement of dermal ulcers and decubiti with collagenase. Geriatrics 1969;24(7):75-86. [MEDLINE: 69219327].
13. Caravaggi 2003 Caravaggi C, De Giglio R, Pritelli C, Sommaria M, Dalla Noce S, Faglia E, et al.HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, multicenter, controlled, randomized clinical trial. Diabetes Care 2003;26(10):2853-9.
14. Casoni 2003 Casoni P, Japichino G. Laser treatment in chronic nonhealing leg ulcers. 2003 UIP World Congress Chapter Meeting, San Diego, California. 2003.
15. Da Costa 1997 Marquesa da Costa R, Jesus FM, Aniceto C, Mendes M. Double-blind randomized placebo-controlled trial of the use of granulocytemacrophage colony-stimulating factor in chronic leg ulcers. American Journal of Surgery 1997;173(3):165-8. [MEDLINE: 97246534].
16. Daltrey 1981 Daltrey DC, Cunliffe WJ. A double-blind study of the effects of benzoyl peroxide 20% and eusol and liquid paraffin on the microbial flora of leg ulcers. Acta Dermato-Venereologica 1981;61(6):575-7. [MEDLINE: 82202157].
17. de la Brassinne 2006 de la Brassinne M, Thirion L, Horvat LI. A novel method of comparing the healing properties of two hydrogels in chronic leg ulcers. Journal of the European Academy of Dermatology and Venereology 2006;20(2):131-5.
18. Delis 2002 Delis KT, Husmann MJ, Nicolaides AN, Wolfe JH, Cheshire NJ. Enhancing foot skin blood flux in peripheral vascular disease using intermittent pneumatic compression: controlled study on claudicants and grafted arteriopaths. World Journal of Surgery 2002;26(7):861-6.
19. Di Mauro 1991 Di Mauro C, Ossino AM, Trefiletti M, Polosa P, Beghe F. Lyophilized collagen in the treatment of diabetic ulcers. Drugs Under Experimental and Clinical Research 1991;17(7):371-3. [MEDLINE: 92174794].
20. Eginton 2003 Eginton MT, Brown KR, Seabrook GR, Towne JB, Cambria RA. A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds. Annals of Vascular Surgery 2003;17(6):645- 9.
21. Enander Malmros 1990 Enander Malmros I, Nilsen T, Lillieborg S. Plasma concentrations and analgesic effect of EMLA (lidocaine/prilocaine) cream for the cleansing of leg ulcers. Acta Dermato-Venereologica 1990;70(3):227-30. [MEDLINE: 90296779].
22. Foelster-Holst 2006 Foelster-Holst R, Nagel F, Zoellner P, Spaeth D. Efficacy of crisis intervention treatment with topical corticosteroid prednicarbat with and without partial wet-wrap dressing in atopic dermatitis. Dermatology 2006;212(1):66-9.
23. Franek 2002 Franek A, Krol P, Kucharzewski M. Does low output laser stimulation enhance the healing of crural ulceration? Some critical remarks. Medical Engineering & Physics 2002;24(9):607-15.
24. Gamborg Nielson 1989 Gamborg Nielsen P, Munk Madsen S, Stromberg L. Treatment of chronic leg ulcers with a hydrocolloid dressing. Acta Dermato-Venereologica Supplementum (Stockholm) 1989;152:1-12.
25. Ghatnekar 2002 Ghatnekar O, Willis M, Persson U. Cost-effectiveness of treating deep diabetic foot ulcers with Promogran in four European countries. Journal of Wound Care 2002;11(2):70-4.
26. Gibson 1986 Gibson B, Harper DR, Nelson EA, Prescott RJ, Ruckley CV. Comparison of a knitted viscose dressing and a hydrocolloid dressing in the treatment of arterial and diabetic leg ulcers. Phlebology '95: Proceedings of the XII Congress Union Internationale De Phlebologie. John Libbey Co. Ltd, 1986:159-60.
27. Holm 1990 Holm J, Andren B, Grafford K. Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine - prilocaine cream, EMLA. Acta Dermato-Venereologica 1990;70(2):132- 46.
28. Holst 1998 Holst RG, Kristofferson A. Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. European Journal of Dermatology 1998;8(4):245-7.
29. Hornemann 1987 Hornemann M, Raptis G. [Therapy of varicose ulcer using crilanomer and dextranomer]. Zeitschrift fur Hautkrankheiten 1987;62(1):41-51.
30. Huber 1991 Huber L. Role of Klion ointment in the treatment of crural ulcer. Therapia Hungarica 1991;39(3):148-50.
31. Janssen 1989 Janssen PA, Janssen H, Cauwenbergh G, DeDoncker P, De Beule K, Lewi P, et al.Use of topical ketanserin in the treatment of skin ulcers: a double-blind study. Journal of the American Academy of Dermatology 1989;21(1):85-90.
32. Jones 2004 Jones W, Ivins N, Price P. Evaluating the effectiveness of Tegapore wound-contact material. Nursing Times 2004;100(4):66- 9.
33. Karlsmark 2003 Karlsmark T, Hahn TW. Cost-effectiveness and performance evaluation of dressings for management of exuding leg ulcers. 13th Conference of the European Wound Management Association. Pisa: Felici Editore, 2003:poster 78/page 209.
34. Karr 2003 Karr JC. External thermoregulation of wounds associated with lower-extremity osteomyelitis. A pilot study. Journal of the American Podiatric Medical Association 2003;93(1):18-22.
35. Knighton 1988 Knighton DR, Doucette M, Fiegel VD, Ciresi K, Butler E, Austin L. The use of platelet derived wound healing formula in human clinical trials. Progress in Clinical and Biological Research 1988;266:319-29.
36. Knighton 1991 Knighton DR, Loss L. Design and implementation of clinical studies in chronic nonhealing wounds. Progress in Clinical and Biological Research 1991;365:67-76.
37. Konig 2005 König M, Vanscheidt W, Augustin M, Kapp H. Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomised trial. Journal of Wound Care 2005;14(7):320-3.
38. Krupski 1991 Krupski WC, Reilly LM, Perez S, Moss KM, Crombleholme PA, Rapp JH. A prospective randomized trial of autologous platelet-derived wound healing factors for treatment of chronic nonhealing wounds: a preliminary report. Journal of Vascular Surgery 1991;14(4):526-32.
39. Lalau 2002 Lalau JD, Bresson R, Charpentier P, Coliche V, Erlher S, Ha Van G, et al.Efficacy and tolerance of calcium alginate versus vaseline gauze dressings in the treatment of diabetic foot lesions. Diabetes & Metabolism 2002;28(3):223-9.
40. Limova 2002 Limova M, Troyer-Caudle J. Controlled, randomized clinical trial of 2 hydrocolloid dressings in the management of venous insufficiency ulcers. Journal of Vascular Nursing 2002 Mar;20(1):22-32.
41. Ljungberg 1998 Ljungberg S. Dextranomer for treatment of venous leg ulcers: paste versus bead formulation. Current Therapeutic Research, Clinical & Experimental 1998;59(7):498-502.
42. Meaume 2005 Meaume S, Ourabah Z, Cartier H, Granel-Brocard F, Combemale P, Bressieux JM, et al.Evaluation of a lipidocolloid wound dressing in the local management of leg ulcers. Journal of Wound Care 2005 Jul; 14(7):329-34.
43. Mehtar 1988 Mehtar S, Fox D. A double-blind comparative study with mupirocin vs placebo base in the treatment of chronic leg ulcers. British Journal of Clinical Practice 1988;42(8):324-8.
44. Milward 1991 Milward P. Examining hydrocolloids. Nursing Times 1991;87(36):70, 72-4.
45. Moffatt 1999 Moffatt CJ, Simon DA, Franks PJ, Connolly M, Fielden S, Groarke L, et al.Randomised trial comparing two four-layer bandage systems in the management of chronic leg ulceration. Phlebology 1999;14(4):139-142.
46. Motta 2004 Motta GJ, Milne CT, Corbett LQ. Impact of antimicrobial gauze on bacterial colonies in wounds that require packing. Ostomy Wound Management 2004;50(8):48-62.
47. Nagl 2003 Nagl M, Nguyen VA, Gottardi W, Ulmer H, Hopfl R. Tolerability and efficacy of N-chlorotaurine in comparison with chloramine T for the treatment of chronic leg ulcers with a purulent coating: a randomized phase II study. British Journal of Dermatology 2003;149(3):590-7.
48. Neander 2004 Neander KD, Hesse F. The protective effects on wound edges of a new preparation. Nursing Times 2004;100(4):61-3.
49. Niezgoda 2005 Niezgoda JA, Van Gils CC, Frykberg RG, Hodde JP. Randomized clinical trial comparing OASIS Wound Matrix to Regranex Gel for diabetic ulcers. Advances in Skin & Wound Care 2005;18:258-66.
50. Ohlsson 1994 Ohlsson P, Larsson K, Lindholm C, Moller M. A cost-effectiveness study of leg ulcer treatment in primary care. Comparison of salinegauze and hydrocolloid treatment in a prospective, randomized study. Scandinavian Journal of Primary Health Care 1994;12(4):295-9.
51. Oluwatosin 2000 Oluwatosin OM, Olabanji JK, Oluwatosin OA, Tijani LA, Onyechi HU. A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. African Journal of Medicine & Medical Sciences 2000;29(1):31-34.
52. Palmieri 1998 Palmieri B, Magri M. A new formulation of collagenase ointment (Iruxol (R) mono) in the treatment of ulcers of the lower extremities. A randomised, placebo-controlled, double-blind study. Clinical Drug Investigation 1998;15(5):381-7.
53. Parnell 2005 Parnell LK, Ciufi B, Gokoo CF. Preliminary use of a hydrogel containing enzymes in the treatment of stage II and stage III pressure ulcers. Ostomy Wound Management 2005;51(8):50-60.
54. Poteliakoff 1958 Poteliakoff A. A new heel pad for prevention of ischaemic ulcers. British Medical Journal 1958;1:278.
55. Rasmussen 1991 Rasmussen LH, Karlsmark T, Avnstorp C, Peters K, Jorgensen M, Jensen LT. Topical human growth hormone treatment of chronic leg ulcers. Phlebology 1991;6(1):23-30.
56. Rayman 2005 Rayman H, Rayman A, Baker NR, Jurgeviciene N, Dargis V, Sulcaite R, et al.Sustained silver-releasing dressing in the treatment of diabetic foot ulcers. British Journal of Nursing 2005;14(2):109- 14.
57. Sawyer 1979 *Sawyer PN, Dowbak G, Sophie Z, Feller J, Cohen L. A preliminary report of the efficacy of Debrisan (dextranomer) in the debridement of cutaneous ulcers. Surgery 1979;85(2):201-4.
58. Sawyer PN, Haque S, Reddy K, Sophie Z, Feller J. Wound healing effects of debrisan on varicose, postoperative, decubitus, and sickle-cell ulcers in man. Vascular Surgery 1979;13:251-6.
59. Steed 1991 Steed D, Goslen JB, Hambley R, Abell E, Hebda P, Webster M. Clinical trials with purified platelet releasate. Progress in Clinical and Biological Research 1991;365:103-13.
60. Stromberg 1984 Stromberg HE, Agren MS. Topical zinc oxide treatment improves arterial and venous leg ulcers. British Journal of Dermatology 1984;111(4):461-8.
61. Thomas 2005 Thomas DR, Diebold MR, Eggemeyer LM. A controlled, randomized, comparative study of a radiant heat bandage on the healing of stage 3-4 pressure ulcers: a pilot study. Journal of the American Medical Directors Association 2005;6(1):46-9.
62. Torra i Bou 2002 Torra i Bou JE, Rueda Lopez J, Camanes G, Herrero Narvaez E, Blanco Blanco J, Martinez-Esparza EH, et al.[Heel pressure ulcers. Comparative study between heel protective bandage and hydrocellular dressing with special form for the heel]. [Spanish] Ulceras por presion en los talones. Estudio comparativo entre el vendaje protector de talones y un aposito hidrocelular con forma especial para los talones. Revista de Enfermeria 2002;25(5):50-6.
63. Veves 2002 Veves A, Sheehan P, Pham HT. A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Archives of Surgery 2002;137(7):822-7.
64. Werner-Schlenzka1994 Werner-Schlenzka H, Kuhlmann RK. Treatment of venous leg ulcers with topical iloprost: a placebo controlled study. Vasa 1994;23(2):145-50.
65. Wu 1996 Wu P, Nelson EA, Reid WH, Ruckley CV, Gaylor JD. Water vapour transmission rates in burns and chronic leg ulcers: influence of wound dressings and comparison with in vitro evaluation. Biomaterials 1996;17(14):1373-7.
66. Yastrub 2004 Yastrub DJ. Relationship between type of treatment and degree of wound healing among institutionalized geriatric patients with stage II pressure ulcers. Care Management Journal 2004;5(4):213-8.
67. Zimny 2003 Zimny S, Meyer MF, Schatz H, Pfohl M. Applied felted foam for plantar pressure relief is an efficient therapy in neuropathic diabetic foot ulcers. Experimental & Clinical Endocrinology & Diabetes 2002 Oct;110(7):325-8.
68. *Zimny S, Schatz H, Pfohl U. The effects of applied felted foam on wound healing and healing times in the therapy of neuropathic diabetic foot ulcers. Diabetic Medicine 2003;20(8):622-5.
69. Zuccarelli 1992 Zuccarelli F. A comparative study of the hydrocellular dressing Allevyn and the hydrocolloid dressing Duoderm in the local treatment of leg ulcers. Phlebologie 1992;45:529-33.
70. Casoni 2001 Casoni P. Randomized trial of a new dressing in the treatment of chronic non-healing ulcers. 15th Annual Congress of the American College of Phlebology, La Quinta, California. 2001.
71. Fischer 1984 Fischer H, Gilliet F, Hornemann M, Leyh F, Lindemayr H, Stegmann W, et al.[Enzymatic debridement in venous ulcus cruris. Report of a multicenter clinical comparative study with various enzyme preparations]. Fortschritte des Medizin 1984;102(10):282-3.
72. Fumal 2002 Fumal I, Braham C, Paquet P, Pierard-Franchimont C, Pierard GE. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof of concept study. Derma-tology 2002;204 (Suppl 1):70-4.
73. Gago 2002 Gago Fornells M, Verdu Soriano J, Garcia Conzalez RF, Guerrero JJ, Rueda Lopez J, Gaztelu Valdes V. Maceration of the skin surrounding the lesions in leg ulcers. Comparison of seven groups of dressings for moist dressing. Proceedings of the 12th Conference of the European Wound Management Association. GNEAUPP - EWMA, 2002:132.
74. Ishibashi 1990 Ishibashi Y, Eto T, Anzai T, Jitsukawa K, Harada S, Nakanishi H, et al.[Clinical Study of A New Hydrocolloid Dressing, Comfeel Ulcus, in Dermal Ulcers: Well-Controlled Comparative Study with Duo Active] Atarashii Sosho Hifukuzai Comfeel Ulcus no Hifu Kaiyo ni Taisuru Rinsho Shiken Seiseki: Futoho ni Yoru Duo Active to no Hikaku. Rinsho Iyaku (Journal of Clinical Therapeutics and Medicines) 1990;6(6):1227-40.
75. Kastelan 1998 Kastelan M, Brajac I, Gruber F. Treatment of leg ulcers with autologous heparinized blood. Acta Dermatovenerologica Alpina, Panonica et Adriatica 1998;7(1):30-34.
76. Klemp 1986a Klemp P, Ravnborg L, Staberg B. [Pain reaction in patients with venous leg ulcers during treatment with Trypure]. Ugeskrift for Laeger 1986;148(13):762-3.
77. Klemp 1986b Klemp P, Staberg B, Ravnborg L. [Local proteolytic treatment of infected varicose ulceration of the legs]. Ugeskrift for Laeger 1986;148(13):760-2.
78. Luongo 2003 Luongo C, Sammartino A, Mascolo L, Campitiello F, Golino M, Luongo M. Advanced dressings and oxigen-ozone therapy to treat ulcer's in chronic obliterant peripheral artheriopaties (AOCP). Proceedings of the 13th Conference of the European Wound Management Association. Pisa: EWMA, 2003:232.
79. Munter 2006 Münter KC, Beele H, Russell L, Crespi A, Gröchenig E, Basse P, et al.Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. Journal of Wound Care 2006 May;15 (5):199-206. [MEDLINE: CN-00556458].
80. Nyfors 1982 Nyfors A, Helland S, Solberg V. Synthaderm in the treatment of leg ulcers. A prospective controlled study. Tidsskrift for den Norske Laegeforening 1982;102:424-5.
81. Prins 2000 Prins C. Autohemotherapy for the treatment of leg ulcers: A randomized, prospective study. Dermatology 201, 91 2000;201:91.
82. Serra 2005 Serra N, Torres OG, Romo MI, Llovera JM, Vigil Escalera LJ, Soto MA, Gonzalez Parra S. [Hydro-colloidal dressings which release hydroactive silver]. Revista de Enfermeria 2005;28(2):13-8.
83. Wollina 1997 Wollina U. Topical therapy of chronic wounds with a newhydropolymer dressing - Clinical experience in 478 patients. Zeitschrift fur Hautkrankheiten 1997;72(7):500-6.
84. Andersson 1993 Andersson E, Hansson C, Swanbeck G. Leg and foot ulcer prevalence and investigation of the peripheral arterial and venous circulation in a randomized elderly population. An epidemiologic survey and clinical investigation. Acta Dermato-Venerologica 1993;73(1):57- 61.
85. Anonymous 1991 Anonymous. Local applications to wounds - II:Dressings for wounds and ulcers. Drug and Therapeutics Bulletin 1991;29(25):97-100.
86. Callam 1985 Callam MJ, Ruckley CV, Harper DR, Dale JJ. Chronic ulceration of the leg: Extent of the problem and provision of care. British Medical Journal 1985;290(6485):1855-6.
87. Callam 1987 Callam MJ, Ruckley CV, Dale JJ, Harper DR. Hazards of compression treatment of the leg: an estimate from Scottish surgeons. British Medical Journal 1987;295(6610):1382.
88. Cullum 1994 Cullum N. Leg ulcer treatments: a critical review (Part 2). Nursing Standard 1994;9(2):32-6.
89. Cullum 1998 Cullum NA, Fletcher AW, Nelson EA, Sheldon TA. Compression for venous leg ulcers. Cochrane Database of Systematic Reviews 2001, Issue 2. Art. No.: CD000265.. DOI:10.1002/14651858.CD000265..
90. Moffatt 1995 Moffatt C, O'Hare L. Ankle pulses are not sufficient to detect impaired arterial circulation in patients with leg ulcers. Journal of Wound Care 1995;4(3):134-8.
91. Taylor 1993 Taylor LM, Porter JM. Natural history and non-operative treatment of chronic lower extremity ischaemia. In: MooreWS editor(s). Vascular Surgery: A Comprehensive Review. Philadelphia: WB Saunders Co, 1993:223-34.
92. Turner 1985 Turner TD. Control the environment to heal the wound. Chemist and Druggist 1985;2:438-44.
93. Vanhoutte 1988 Vanhoutte P, Amery S, Birkenhager W, Breckenridge A, Buhler F, Distler A. Serotenergic mechanisms in hypertension. Focus on the effects of ketanserin. Hypertension 1988;11(2):111-33.
94. Winter 1962 Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature 1962;193:293-4.