Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine?

Journal of Ethnopharmacology

Volumn 117, Issue 2, 2008, Pages 378-384

  Zhuang, Yan ^a   Yan, Jingjing ^a   Zhu, Wei ^b   Chen, Lirong ^a   Liang, Dehai ^a   Xu, Xiaojie ^a  

^a PEKING UNIVERSITY   (China)

^b GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

Aggregate; Dynamic light scattering; Traditional Chinese Medicine

Indexed keywords

CHINESE DRUG; DIPEPTIDYL CARBOXYPEPTIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; JING GUAN TANG; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG; XUE FU ZHU YU TANG;

ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG TARGETING; HUMAN; HUMAN CELL; LIGHT SCATTERING; MEDICAL RESEARCH; TRANSMISSION ELECTRON MICROSCOPY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CACO-2 CELLS; CARDIOVASCULAR AGENTS; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; HUMANS; INTESTINAL ABSORPTION; LIGHT; MEDICINE, CHINESE TRADITIONAL; NITRIC OXIDE SYNTHASE TYPE II; PARTICLE SIZE; PEPTIDYL-DIPEPTIDASE A; PLANT EXTRACTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; SCATTERING, RADIATION;

CITRUS MAXIMA;

EID: 41949083870     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.02.017     Document Type: Article

References (13)

1. Feng B.Y., Shelat A., Doman T.N., Guy R.K., and Shoichet B.K. High-throughput assays for promiscuous inhibitors. Nature Chemical Biology 1 (2005) 146-148
2. Feng B.Y., and Shoichet B.K. A detergent-based assay for the detection of promiscuous inhibitors. Nature Protocols 1 (2006) 550-553
3. Feng B.Y., and Shoichet B.K. Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures. Journal of Medicinal Chemistry 49 (2006) 2151-2154
4. Frenkel Y.V., Clark A.D., Das K., Wang Y.H., Lewi P.J., Janssen P.A.J., and Arnold E. Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. Journal of Medicinal Chemistry 48 (2005) 1974-1983
5. McGovern S.L., Caselli E., Grigorieff N., and Shoichet B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. Journal of Medicinal Chemistry 45 (2002) 1712-1722
6. McGovern S.L., Helfand B.T., Feng B.Y., and Shoichet B.K. A specific mechanism of nonspecific inhibition. Journal of Medicinal Chemistry 46 (2003) 4265-4272
7. McGovern S.L., and Shoichet B.K. Kinase inhibitors: not just for kinases anymore. Journal of Medicinal Chemistry 46 (2003) 1478-1483
8. Provencher S.W. CONTIN: a general purpose constrained regularization program for inverting noisy linear algebraic and integral equations. Computer Physics Communications 27 (1982) 229-242
9. Rishton G.M. Reactive compounds and in vitro false positives in HTS. Drug Discovery Today 2 (1997) 382-384
10. Seidler J., McGovern S.L., Doman T., and Shoichet B.K. Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of Medicinal Chemistry 46 (2003) 4477-4486
11. Shen Z., Chen P., Shen J., Dong Z., and Liu J. Effects of the fraction from Phyllanthus Urinaria on thrombolysis and the activity of PAI-1 and tPA. Natural product research and development. 15 (2003) 441-445
12. Shoichet B.K. Screening in a spirit haunted world. Drug Discovery Today 11 (2006) 607-615
13. Tian X.J., Yang X.D., Wang K., and Yang X.W. The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranoside in the human intestinal cell line Caco-2. Pharmaceutical Research 23 (2006) 1721-1728