Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3917-3925

  Rosen, Mark D ^a   Hack, Michael D ^a   Allison, Brett D ^a   Phuong, Victor K ^a   Woods, Craig R ^a   Morton, Magda F ^a   Prendergast, Clodagh E ^a   Barrett, Terrance D ^a   Schubert, Carsten ^a   Li, Lina ^a   Wu, Xiaodong ^a   Wu, Jiejun ^a   Freedman, Jamie M ^a   Shankley, Nigel P ^a   Rabinowitz, Michael H ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

CCK 2; CCK B; Cholecystokinin 2 receptor antagonists; Gastrin receptor antagonists

Indexed keywords

1 METHYL 1H BENZOTRIAZOLE 4 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL) PHENYL]AMIDE; 1 METHYL 1H BENZOTRIAZOLE 4 SULFONYL CHLORIDE; 2 (BENZO[1,2,5]THIADIAZOLE 4 SULFONYLAMINO) 4 BROMO N (4 CHLOROBENZYL)BENZAMIDE; 2 METHYL 2H BENZOTRIAZOLE 4 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; 2 METHYL 2H BENZOTRIAZOLE 4 SULFONYL CHLORIDE; 2 METHYL 2H BENZOTRIAZOLE 5 SULFONIC ACID; 2 METHYL 2H BENZOTRIAZOLE 5 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; 2 METHYL BENZOTHIAZOLE 7 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; 2,3 DIAMINOBENZENESULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; 5 CHLORO CONGENER; BENZIMIDAZOLE 4 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; BENZO[1,2,5]THIADIAZOLE 4 SULFONIC ACID[5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; BENZOTHIAZOLE 4 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; BENZOTHIAZOLE 6 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; BENZOTHIAZOLE 7 SULFONIC ACID [5 BROMO 2 (PIPERIDINE 1 CARBONYL)PHENYL]AMIDE; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; LIVER ENZYME; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG ABSORPTION; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION KINETICS; PHARMACOPHORE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZOTHIAZOLES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTOR, CHOLECYSTOKININ A; RECEPTOR, CHOLECYSTOKININ B; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 41849144879     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.059     Document Type: Article

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