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1
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0037076432
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BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
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Loukinov D.I., Pugacheva E., Vatolin S., Pack S.D., Moon H., Chernukhin I., Mannan P., Larsson E., Kanduri C., Vostrov A.A., Cui H., Niemitz E.L., Rasko J.E., Docquier F.M., Kistler M., Breen J.J., Zhuang Z., Quitschke W.W., Renkawitz R., Klenova E.M., Feinberg A.P., Ohlsson R., Morse III H.C., and Lobanenkov V.V. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc. Natl. Acad. Sci. USA 99 (2002) 6806-6811
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Ohlsson, R.22
Morse III, H.C.23
Lobanenkov, V.V.24
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The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer
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Klenova E.M., Morse III H.C., Ohlsson R., and Lobanenkov V.V. The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin. Cancer Biol. 12 (2002) 399-414
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Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes
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Vatolin S., Abdullaev Z., Pack S.D., Flanagan P.T., Custer M., Loukinov D.I., Pugacheva E., Hong J.A., Morse III H., Schrump D.S., Risinger J.I., Barrett J.C., and Lobanenkov V.V. Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. Cancer Res. 65 (2005) 7751-7762
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Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells
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Hong J.A., Kang Y., Abdullaev Z., Flanagan P.T., Pack S.D., Fischette M.R., Adnani M.T., Loukinov D.I., Vatolin S., Risinger J.I., Custer M., Chen G.A., Zhao M., Nguyen D.M., Barrett J.C., Lobanenkov V.V., and Schrump D.S. Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells. Cancer Res. 65 (2005) 7763-7774
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Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression
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Risinger J.I., Chandramouli G.V., Maxwell G.L., Custer M., Pack S., Loukinov D., Aprelikova O., Litzi T., Schrump D.S., Murphy S.K., Berchuck A., Lobanenkov V., and Barrett J.C. Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. Clin. Cancer Res. 13 (2007) 1713-1719
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A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5′-flanking sequence of the chicken c-myc gene
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CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells
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Qi C.F., Martensson A., Mattioli M., Dalla-Favera R., Lobanenkov V.V., and Morse III H.C. CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells. Proc. Natl. Acad. Sci. USA 100 (2003) 633-638
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CTCF binds the proximal exonic region of hTERT and inhibits its transcription
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A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers
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Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites
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Ghochikyan A., Mkrtichyan M., Loukinov D., Mamikonyan G., Pack S.D., Movsesyan N., Ichim T.E., Cribbs D.H., Lobanenkov V.V., and Agadjanyan M.G. Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites. J. Immunol. 178 (2007) 566-573
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DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice
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